Dopamine D2 receptor isoforms expressed in AtT20 cells differentially couple to G proteins to acutely inhibit high voltage-activated calcium channels

Journal of Neurochemistry

Volumn 73, Issue 6, 1999, Pages 2375-2382

  Wolfe, Shannyn E ^a   Morris, Stephen J ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Antisense deoxynucleotide; Fluorescence; Membrane delimited; Quinpirole; Signal transduction; Video microscopy

Indexed keywords

ADENYLATE CYCLASE; CALCIUM CHANNEL; CALCIUM ION; DOPAMINE 2 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; ADENYLATE CYCLASE TOXIN; BORDETELLA VIRULENCE FACTOR; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; COMPLEMENTARY DNA; HYBRID PROTEIN; ISOPROTEIN; POTASSIUM; TUMOR PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; ENZYME INHIBITION; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SECRETORY CELL; SIGNAL TRANSDUCTION; ACTION POTENTIAL; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; GENETICS; HYPOPHYSIS TUMOR; ION TRANSPORT; METABOLISM; MICROSCOPY; PATHOLOGY; PHYSIOLOGY; PROTEIN BINDING;

ANIMALIA;

ACTION POTENTIALS; ADENYLATE CYCLASE TOXIN; ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; DNA, ANTISENSE; GTP-BINDING PROTEINS; ION TRANSPORT; MICE; MICROSCOPY, FLUORESCENCE; MICROSCOPY, VIDEO; NEOPLASM PROTEINS; PITUITARY NEOPLASMS; POTASSIUM; PROTEIN BINDING; PROTEIN ISOFORMS; RECEPTORS, DOPAMINE D2; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED; VIRULENCE FACTORS, BORDETELLA;

EID: 0032589998     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0732375.x     Document Type: Article

References (58)

1. 2 dopamine receptor in the intermediate lobe of the rat pituitary gland. J. Biochem. (Tokyo) 103, 436-441.
2. Baertschi A. J., Audigier Y., Lledo P. M., Israel J. M., Bockaert J., and Vincent J. D. (1992) Dialysis of lactotropes with antisense oligonucleotides assigns guanine nucleotide binding protein subtypes to their channel effectors. Mol. Endocrinol. 6, 2257-2265.
3. Beatty D. M., Chronwall B. M., Howard D. E., Wiegmann T. B., and Morris S. J. (1993) Calcium regulation of intracellular pH in pituitary intermediate lobe melanotropes. Endocrinology 133, 972-984.
4. Bourne H. R. (1997) How receptors talk to trimeric G proteins. Curr. Opin. Cell Biol. 9, 134-142.
5. o with calcium channels by the calcium channel β subunit in rat neurones. J. Physiol. (Lond.) 485, 365-372.
6. αo in rat sympathetic neurones. J. Physiol. (Lond.) 477, 415-422.
7. 3H-thymidine uptake. Endocrinology 120, 1201-1211.
8. Chronwall B. M., Bishop J. F., and Gehlert D. R. (1988) Rat intermediate lobe in culture: a histological and biochemical characterization. Peptides 9, 169-180.
9. 2+ channel activity via c-fos. Endocrinology 136, 614-621.
10. Clapham D. E. (1994) Direct G protein activation of ion channels? Annu. Rev. Neurosci. 17, 441-464.
11. o heterotrimer couples somatostatin receptors to voltage-gated calcium in RINm5F cells. FEBS Lett. 380, 137-141.
12. Deutch A. Y. (1993) Prefrontal cortical dopamine systems and the elaboration of functional corticostriatal circuits: implications for schizophrenia and Parkinson's disease. J. Neural Transm. Gen. Sect. 91, 197-221.
13. De Waard M., Liu H., Walker D., Scott V. E. S., Curnett C. A., and Campbell K. P. (1997) Direct binding of G-protein βγ complex to voltage-dependent calcium channels. Nature 385, 446-450.
14. Diversé-Pierluissi M., Goldsmith P. K., and Dunlap K. (1995) Transmitter-mediated inhibition of N-type calcium channels in sensory neurons involves multiple GTP-binding proteins and subunits. Neuron 14, 191-200.
15. 2+ channel inhibition. Neuron 16, 579-585.
16. Diversé-Pierluissi M., Remmers A. E., Neubig R. R., and Dunlap K. (1997) Novel form of crosstalk between G protein and tyrosine kinase pathways. Proc. Natl. Acad. Sci. USA 94, 5417-5421.
17. Dolphin A. C. (1995) Voltage-dependent calcium channels and their modulation by neurotransmitters and G proteins. Exp. Physiol. 80, 1-36.
18. Douglas W. W. and Taraskevich P. S. (1982) Slowing effects of dopamine and calcium-channel blockers on frequency of sodium spikes in rat pars intermedia cells. J. Physiol. (Lond.) 326, 201-211.
19. Dunlap K. (1997) Calcium channels. Integration hot-spot gets hotter. Nature 385, 394-397.
20. 2+ channels in rat dorsal root ganglion neurons in vitro. Neuron 2, 1185-1193.
21. Gehlert D. R., Bishop J. F., Schafer M. P., and Chronwall B. M. (1988) Rat intermediate lobe in culture: dopamine regulation of POMC synthesis and cell proliferation. Peptides 9, 161-168.
22. 2+ channels in rat pituitary GH3 cells. Proc. Natl. Acad. Sci. USA 90, 6265-6269.
23. 2 receptor directs specificity of coupling to G-proteins. J. Biol. Chem. 270, 7354-7358.
24. Harish O. E. and Role L. W. (1992) Activation of phosphoinositide turnover and protein kinase C by neurotransmitters that modulate calcium channels in embryonic chick sensory neurons. Int. J. Dev. Neurosci. 10, 421-433.
25. 2+ channels by G-protein βγ subunits. Nature 380, 258-262.
26. Hescheler J. and Schultz G. (1993) G-proteins involved in the calcium channel signaling system. Curr. Opin. Neurobiol. 3, 360-367.
27. Hille B. (1994) Modulation of ion-channel function by G-protein-coupled receptors. Trends Neurosci. 17, 531-536.
28. o proteins functionally coupling galanin receptors to voltage-gated calcium channels. EMBO J. 14, 4728-4737.
29. Keja J. A., Stoof J. C., and Kits K. S. (1992) Dopamine D2 receptor stimulation differentially affects voltage-activated calcium channels in rat pituitary melanotropic cells. J. Physiol. (Lond.) 450, 409-435.
30. Kleuss C., Hescheler J., Ewel C., Rosenthal W., Schultz G., and Wittig B. (1991) Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents. Nature 353, 43-48.
31. Kleuss C., Scherübl H., Hescheler J., Schultz G., and Wittig B. (1992) Different β-subunits determine G-protein interaction with transmembrane receptors. Nature 358, 424-426.
32. Kleuss C., Scherübl H., Hescheler J., Schultz G., and Wittig B. (1993) Selectivity in signal transduction determined by γ subunits of heterotrimeric G proteins. Science 259, 832-834.
33. B receptors in rat brain slices. Neuropharmacology 35, 703-712.
34. Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head bacteriophage T4. Nature 227, 680-685.
35. Liu Y. F., Jakobs K. H., Rasenick M. M., and Albert P. R. (1994) G-protein specificity in receptor-effector coupling. J. Biol. Chem. 269, 13880-13886.
36. 2+ currents in rat anterior pituitary cells. Neuron 8, 455-463.
37. Malek D., Munch G., and Palm D. (1993) Two sites in the third inner loop of the dopamine D2 receptor are involved in functional G protein-mediated coupling to adenylate cyclase. FEBS Lett. 325, 215-219.
38. Morris S. J. (1993) Simultaneous multiple detection of fluorescent molecules: rapid kinetic imaging of calcium and pH in living cells, in Optical Microscopy: Emerging Methods and Applications (Herman B. and Lemasters J. J., eds), pp. 177-212. Academic Press, San Diego.
39. Morris S. J., Wiegmann T. B., Welling L. W., and Chronwall B. M. (1994) Rapid simultaneous estimation of intracellular calcium and pH. Methods Cell Biol. 40, 183-220.
40. 2+ channels. J. Neurochem. 71, 1329-1332.
41. 2 dopamine receptor mRNA after denervation. Proc. Natl. Acad. Sci. USA 88, 2802-2806.
42. o-subtype from mammalian brain. Biochem. J. 300, 387-394.
43. Nussinovitch I. and Kleinhaus A. L. (1992) Dopamine inhibits voltage-activated calcium channel currents in rat pars intermedia pituitary cells. Brain Res. 574, 49-55.
44. Paulssen R. H., Paulssen E. J., Gautvik K. M., and Gordeladze J. O. (1992) The thyroliberin receptor interacts directly with a stimulatory guanine-nucleotide-binding protein in the activation of adenylyl cyclase in GH3 rat pituitary tumour cells. Evidence obtained by the use of antisense RNA inhibition and immunoblocking of the stimulatory guanine-nucleotide-binding protein. Eur. J. Biochem. 204, 413-418.
45. iα proteins to inhibit adenylyl cyclase. J. Biol. Chem. 269, 23120-23127.
46. Sibley D. R. and Monsma F. J. Jr. (1992) Molecular biology of dopamine receptors. Trends Pharmacol. Sci. 13, 61-69.
47. Spampinato S., Ganossa M., Carboni L., Campi G., Leanza G., and Ferri S. (1994) Inhibition of proopiomelanocortin expression by an oligodeoxynucleotide complementary to beta-endorphin mRNA. Proc. Natl. Acad Sci. USA 91, 8072-8076.
48. Stack J. and Surprenant A. (1991) Dopamine actions on calcium currents, potassium currents and hormone release in rat melanotrophs. J. Physiol. (Lond.) 439, 37-58.
49. 2+]. Neurosci. Lett. 112, 205-209.
50. 2 receptor. Trends Pharmacol. Sci. 10, 74-77.
51. 2 dopamine receptor mRNA subtypes in rat brain. Neurochem. Int. 20 (Suppl.), 49S-58S.
52. 2+] and pH in single MDCK and glomerular epithelial cells. Am. J. Physiol. 265, C1184-C1190.
53. Williams P. J., MacVicar B. A., and Pittman Q. J. (1990) Synaptic modulation by dopamine of calcium currents in rat pars intermedia. J. Neurosci. 10, 757-763.
54. Wojcik W. J. and Neff N. H. (1984) Gamma-aminobutyric acid B receptors are negatively coupled to adenylate cyclase in brain, and in the cerebellum these receptors may be associated with granule cells. Mol. Pharmacol. 25, 24-28.
55. Wojcik W. J., Travagli R. A., Costa E., and Bertolino M. (1990) Baclofen inhibits with high affinity an L-type-like voltage-dependent calcium channel in cerebellar granule cell cultures. Neuropharmacology 29, 969-972.
56. 2+ channels via a membrane-delimited pathway. J. Neurochem. 72, 479-490.
57. i subunit. Nature 385, 442-446.
58. 2+ channels support their inhibition by G proteins. Neuron 17, 991-1003.