Depletion of Vβ4 TCR does not induce resistance to EAN - further evidence for diversity of TCR usage

Journal of Neuroimmunology

Volumn 101, Issue 1, 1999, Pages 34-38

  Stienekemeier, M ^a   Weishaupt, A ^a   Gold, R ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Antibody; EAN; Guillain Barre syndrome; Neuropathies; T cell receptor; Therapy

Indexed keywords

IDIOTYPIC ANTIBODY; RECEPTOR ANTIBODY; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CELL PROLIFERATION; FLOW CYTOMETRY; GUILLAIN BARRE SYNDROME; IMMUNIZATION; LYMPH NODE CELL; NEURITIS; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CELL CULTURE; FEMALE; IMMUNOLOGY; LEWIS RAT; LYMPHOCYTE DEPLETION; PHYSIOLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; CELLS, CULTURED; FEMALE; IMMUNIZATION; LYMPHOCYTE DEPLETION; NEURITIS, AUTOIMMUNE, EXPERIMENTAL; RATS; RATS, INBRED LEW; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 0032589996     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00129-0     Document Type: Article

References (22)

1. Brostoff S.W., Levit S., Powers J.M. Induction of experimental allergic neuritis with a peptide from myelin P2 basic protein. Nature. 268:1977;752-753.
2. Chan, A., Gold, R., Giegerich, G., Herrmann, T., Jung, S., Toyka, K.V., Hartung, H.-P., 1999. Usage of Vβ3.3 T-cell receptor by myelin basic protein-specific encephalitogenic T-cell lines in the Lewis rat. J. Neurosci. Res. (in press).
3. Clark L., Heber Katz E., Rostami A. Shared T-cell receptor gene usage in experimental allergic neuritis and encephalomyelitis [see comments]. Ann. Neurol. 31:1992;587-592.
4. Gold R., Giegerich G., Hartung H.-P., Toyka K.V. T-cell receptor (TCR) usage in Lewis rat experimental autoimmune encephalomyelitis: TCR beta-chain-variable-region V beta 8.2-positive T cells are not essential for induction and course of disease. Proc. Natl. Acad. Sci. U.S.A. 92:1995;5850-5854.
5. Gold R., Toyka K.V., Hartung H.-P. Synergistic effect of IFN-gamma and TNF-α on expression of immune molecules and antigen presentation by Schwann cells. Cell. Immunol. 165:1995;65-70.
6. Hartung H.-P., Schäfer B., Heiniger K., Stoll G., Toyka K. The role of macrophages and eicosanoids in the pathogenesis of experimental allergic neuritis. Brain. 111:1988;1039-1059.
7. Hartung, H.-P., Stoll, G., Toyka, K.V., 1993. Immune reactions in the peripheral nervous system. In: Dyck, T.P., Griffin, J.W., Low, P.A., Poduslo, J.F. (Eds.), Peripheral Neuropathy. Saunders, Philadelphia, pp. 418-444.
8. Hughes, R.A.C., 1990. Guillain-Barré syndrome. Springer-Verlag, London.
9. Hünig T., Wallny H.-J., Hartley J.K., Lawtzky A., Tiefenthaler G. A monoclonal antibody to a constant determinant of the rat T cell receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes. J. Exp. Med. 169:1989;73-86.
10. Imrich H., Kugler Ch., Torres-Nagel N., Dörries R., Hünig T. Prevention and treatment of Lewis rat experimental allergic encephalomyelitis with a monoclonal antibody to the T cell receptor Vβ8.2 segment. Eur. J. Immunol. 25:1995;1960-1964.
11. Jung S., Schluesener H.J., Toyka K.V., Hartung H.-P. T cell vaccination does not induce resistance to experimental autoimmune neuritis. J. Neuroimmunol. 35:1991;1-11.
12. Kadlubowski M., Hughes R.A.C. Identification of the neuritogen for experimental allergic neuritis. Nature. 277:1979;140-141.
13. King R.H.M., Craggs R.I., Cross M.L.P., Thomas P.K. Effects of glucocorticoids on experimental allergic neuritis. Exp. Neurol. 87:1985;9-19.
14. Lannes Vieira J., Goudable B., Drexler K., Gehrmann J., Torres-Nagel N., Hünig T., Wekerle H. Encephalitogenic, myelin basic protein-specific T cells from naive rat thymus: preferential use of the T cell receptor gene V beta 8.2 and expression of the CD4-CD8-phenotype. Eur. J. Immunol. 25:1995;611-616.
15. Linington C., Izumo S., Suzuki M., Uyemura K., Meyermann R., Wekerle H. A permanent rat T cell line that mediates experimental allergic neuritis in the Lewis rat in vivo. J. Immunol. 133:1984;1946-1950.
16. Miltenyi S., Müller W., Weilchel W., Radbruch A. High gradient magnetic cell separation with MACS. Cytometry. 11:1990;231-238.
17. Stienekemeier M., Herrmann T., Kruse N., Weishaupt A., Weilbach F.X., Giegerich G., Theofilopoulos A.N., Jung S., Gold R. Heterogeneity of T-cell receptor usage in experimental autoimmune neuritis in the Lewis rat. Brain. 122:1999;523-535.
18. Vandenbark A.A., Hashim G.A., Offner H. T cell receptor peptides in treatment of autoimmune disease: rationale and potential. J. Neurosci. Res. 43:1996;391-402.
19. Weilbach F.X., Jung S., Hartung H.-P., Toyka K.V., Giegerich G. T-cell receptor Vβ-element expression in peripheral nerves of Lewis rats suffering from experimental autoimmune neuritis. J. Neuroimmunol. 79:1997;69-75.
20. Weishaupt A., Giegerich G., Jung S., Gold R., Enders U., Pette M., Hartung H.-P., Toyka K.V. T cell antigenic and neuritogenic activity of recombinant human peripheral myelin P2 protein. J. Neuroimmunol. 63:1995;149-156.
21. Weishaupt A., Gold R., Giegerich G., Hartung H.-P., Toyka K. Antigen therapy eliminates T-cell inflammation by apoptosis: effective treatment of experimental autoimmune neuritis with recombinant myelin protein P2. Proc. Natl. Acad. Sci. U.S.A. 94:1997;1338-1342.
22. Zhang X.M., Esch T.R., Clark L., Gregorian S., Rostami A., Otvos L. Jr., Heber Katz E. Neuritogenic Lewis rat T cells use Tcrb chains that include a new Tcrb-V8 family member. Immunogenetics. 40:1994;266-270.