The effect of Cys LT1 receptor blockade on airway responses to allergen

Pharmacotherapy

Volumn 19, Issue 11 I, 1999, Pages 1243-1251

  Hendeles, Leslie ^a   Davison, Donald ^b   Harman, Eloise ^c   Sherman, James M ^b  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; LEUKOTRIENE RECEPTOR; VERLUKAST; CYSTEINE; CYSTEINYL-LEUKOTRIENE; LEUKOTRIENE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; PEPTIDOLEUKOTRIENE; PROPIONIC ACID DERIVATIVE; QUINOLINE DERIVATIVE;

ADULT; AIRWAY DYNAMICS; AIRWAY OBSTRUCTION; ARTICLE; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSING OVER; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG POTENCY; EOSINOPHILIA; FORCED EXPIRATORY VOLUME; HUMAN; MALE; MUCUS SECRETION; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY;

ADULT; AIRWAY OBSTRUCTION; ALLERGENS; BRONCHIAL HYPERREACTIVITY; CROSS-OVER STUDIES; CYSTEINE; DOUBLE-BLIND METHOD; FORCED EXPIRATORY VOLUME; HUMANS; LEUKOTRIENE ANTAGONISTS; LEUKOTRIENES; MALE; PROPIONATES; QUINOLINES;

EID: 0032589594     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.19.16.1243.30878     Document Type: Article

References (31)

1. Holtzman MJ. Arachidonic acid metabolism. Implications of biological chemistry for lung function and disease. Am Rev Respir Dis 1991; 143:188-203.
2. 4 from the urine of patients with airway obstruction. Am Rev Respir Dis 1992; 146:104-8.
3. Wenzel SE, Trudeau JB, Kaminsky DA, Cohn J, Martin RJ, Wescott JY. Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma. Am J Respir Crit Care Med 1995;152:897-905.
4. 4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge. Am Rev Respir Dis 1990;142:112-19.
5. 4 after exercise and attenuation of exercise induced bronchospasm by montelukast, a cysteinyl leukotriene receptor antagonist. Thorax 1997;52:1030-5.
6. Israel E, Fischer AR, Rosenberg MA, et al. The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin. Am Rev Respir Dis 1993;148:1447-51.
7. O'Byrne PM, Dolovich J, Hargreave FE. Late asthmatic responses. Am Rev Respir Dis 1987;136:740-51.
8. Durham SR, Craddock CF, Cookson WO, Benson MK. Increases in airway responsiveness to histamine precede allergen-induced late asthmatic responses. J Allergy Clin Immunol 1988;82:764-70.
9. 4 in atopic subjects. J Allergy Clin Immunol 1989;83:939-44.
10. Bel EH, Timmers MC, Dijkman JH, Stahl EG, Sterk PJ. The effect of an inhaled leukotriene antagonist, L-648,051, on early and late asthmatic reactions and subsequent increase in airway responsiveness in man. J Allergy Clin Immunol 1990;85:1067-75.
11. Hui KP, Taylor IK, Taylor GW, et al. Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients. Thorax 1991;46:184-9.
12. Diamant Z, Timmers MC, van der Veen H, et al. The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen induced airway responses in asthmatic subjects in vivo. J Allergy Clin Immunol 1995;95:42-51.
13. Taylor IK, O'Shaughnessy KM, Fuller RW, Dollery CT. Effect of cysteinyl-leukotriene receptor antagonist ICI 204.219 on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjects. Lancet 1991;337:690-4.
14. Friedman BS, Bel EH, Buntinx A, et al. Oral leukotriene inhibitor (MK-886) blocks allergen induced airway responses. Am Rev Respir Dis 1993;147:839-44.
15. 4 receptor blockade inhibits the immediate and late bronchoconstrictor responses to inhaled antigen in patients with asthma. J Allergy Clin Immunol 1992;90:193-201.
16. Hamilton A, Faiferman I, Stober P, Watson RM, O'Byrne PM. Pranlukast, a cysteinyl leukotriene receptor antagonist, attenuates allergen-induced early-and late-phase broncho-constriction and airway hyperresponsiveness in asthmatic subjects. J Allergy Clin Immunol 1998; 102:177-83
17. Hamilton AL, Watson RM, Wyile G, O'Byrne PM. Attenuation of early and late phase allergen-induced bronchoconstriction in asthmatic subjects by a 5-lipoxygenase activating protein antagonist, BAYx 1005. Thorax 1997;52:348-54.
18. 4-induced bronchoconstriction in the human. Am Rev Respir Dis 1991;144:617-21.
19. Holgate ST, Bradding P, Sampson AP. Leukotriene antagonists and synthesis inhibitors: new directions in asthma therapy. J Allergy Clin Immunol 1996;98:1-13.
20. Horwitz RJ, McGill KA, Busse WW. The role of leukotriene modifiers in the treatment of asthma. Am J Respir Crit Care Med 1998;157:1363-71.
21. Morris JF, Koski A, Johnson LC. Spirometric standards for healthy nonsmoking adults. Am Rev Respir Dis 1971;103:57-67.
22. Cockcroft DW, Killian DN, Mellon JJ, Hargreave FE. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy 1977;7:235-43.
23. Cockcroft DW, Murdock KY. Comparative effects of inhaled salbutamol, sodium cromoglycate, and beclomethasone dipropionate on allergen-induced early asthmatic responses, late asthmatic responses, and increased bronchial responsiveness to histamine. J Allergy Clin Immunol 1987;79:734-40.
24. Eggleston PA, Beasley PP. Bronchodilation and inhibition of induced asthma by adrenergic agonists. Clin Pharmacol Ther 1981;29:505-10.
25. Lai CK, Twentyman OP, Holgate ST. The effect of an increase in inhaled allergen dose after rimeterol hydrobromide on the occurrence and magnitude of the late asthmatic response and the associated change in nonspecific bronchial responsiveness. Am Rev Respir Dis 1989;140:917-23.
26. Schneider H. Truncated and censored samples from normal populations. New York: Marcel Dekker, 1986.
27. 4-receptor antagonist. N Engl J Med 1990;323:1736-9.
28. 4 and granulocytic infiltration into asthmatic airways. Lancet 1993;341:989-90.
29. 4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors. Proc Natl Acad Sci USA 1984;81:4922-5.
30. 4 enhance histamine responsiveness in asthmatic airways. Am Rev Respir Dis 1991;144:1053-7.
31. Tattersfield AE. Measurement of bronchial reactivity: a question of interpretation. Thorax 1981;36:561-5.