Expression of neurotrophins, GDNF, and their receptors in rat thyroid tissue

Cell and Tissue Research

Volumn 295, Issue 3, 1999, Pages 467-475

  Belluardo, N ^a   Mudo G ^b   Caniglia, G ^b   Corsaro, M ^c   Cheng, Q ^b   Frasca, F ^b   Belfiore, A ^b   Condorelli, D F ^c  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c UNIVERSITY OF CATANIA   (Italy)

Author keywords

BDNF; Brain derived neurotrophic factor; GDNFR ; Glial cell line derived neurotrophic factor, GDNF; NT 3; NT 4; Rat; Ret; Thyroid tissue; trk receptors

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR RECEPTOR; DROSOPHILA PROTEIN; GDNF PROTEIN, HUMAN; GDNF PROTEIN, RAT; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR; MESSENGER RNA; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NERVE PROTEIN; NEUROTROPHIN 3; NEUROTROPHIN 3 RECEPTOR; NEUROTROPHIN 4; ONCOPROTEIN; PROTEIN RET; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE A; RET ONCOGENE PROTEIN, DROSOPHILA; RET PROTEIN, RAT; NEUROTROPHIN; NEUROTROPHIN RECEPTOR;

ANIMAL; ARTICLE; BIOSYNTHESIS; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; RAT; THYROID GLAND; ULTRASTRUCTURE; ANIMAL TISSUE; CONTROLLED STUDY; HIPPOCAMPUS; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; RIBONUCLEASE PROTECTION ASSAY; THYROID FOLLICLE CELL; THYROID PARAFOLLICULAR CELL;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DROSOPHILA PROTEINS; GENE EXPRESSION; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; HUMANS; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEUROTROPHIN 3; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, CILIARY NEUROTROPHIC FACTOR; RECEPTOR, TRKA; RECEPTOR, TRKC; RECEPTORS, NERVE GROWTH FACTOR; RNA, MESSENGER; THYROID GLAND;

EID: 0032588379     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410051252     Document Type: Article

References (63)

1. Arenas E, Trupp M, Akerud P, Ibanez CF (1995) GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo. Neuron 15:1465-1473
2. Baloh RH, Tansey MG, Golden JP, Creedon DJ, Heuckeroth RO, Keck CL, Zimonjic DB, Popescu NC, Johnson EM Jr, Milbrandt J (1997) TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron 18:793-802
3. Baloh RH, Gorodinsky A, Golden JP, Tansey MG, Keck CL, Popescu NC, Johnson EM Jr, Milbrandt J (1998) GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc Natl Acad Sci USA 95:5801-5806
4. Beck KD, Valverde J, Alexi T, Poulsen K, Moffat B, Vandlen RA, Rosenthal A, Hefti F (1995) Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373:339-341
5. Borganzone I, Pierotti MA, Monzini N, Mondellini P, Manenti G, Donghi R, Pilotti S, Grieco M, Santoro M, Fusco A, Vecchio G, Della Porta G (1989) High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma. Oncogene 4:1457-1462
6. Buj-Bello A, Buchman VL, Horton A, Rosenthal A, Davies AM (1995) GDNF is an age-specific survival factor for sensory and autonomic neurons. Neuron 15:821-828
7. Buj-Bello A, Adu J, Pinon LG, Horton A, Thompson J, Rosenthal A, Chinchetru M, Buchman VL, Davies AM (1997) Neurturin responsiveness requires a GPI-linked receptor and the ret receptor tyrosine kinase. Nature 387:721-724
8. Cardinali DP, Stern JE (1994) Peripheral neuroendocrinology of the cervical autonomic nervous system. Braz J Med Biol Res 27:573-599
9. Chao MV (1992) Neurotrophin receptors: a window into neuronal differentiation. Neuron 9:583-593
10. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
11. Chun LL, Patterson PH (1977) Role of nerve growth factor in the development of rat sympathetic neurones in vitro. II. Developmental studies. J Cell Biol 75:705-711
12. Condorelli DF, Dell'Albani P, Mudò G, Timmusk T, Belluardo N (1994) Expression of neurotrophins and their receptors in primary astroglial cultures: induction by cAMP-elevating agents. J Neurochem 63:509-516
13. Dicou E, Lee J, Brachet P (1986) Synthesis of nerve growth factor mRNA and precursor protein in the thyroid and parathyroid glands of the rat. Proc Natl Acad Sci 83:7084-7088
14. Durbec P, Marcos-Gutierrez CV, Kilkenny C, Grigoriou M, Wartiowaara K, Suvanto P, Smith D, Ponder B, Costantini F, Saarma M, Sariola H, Pachnis V (1996) GDNF signalling through the ret receptor tyrosine kinase. Nature 381:789-793
15. Eide FF, Lowenstein DH, Reichardt LF (1993) Neurotrophins and their receptors - current concepts and implications for neurologic disease. Exp Neurol 121:200-214
16. Ernfors P, Wetmore C, Olson L, Persson H (1990) Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family. Neuron 5:511-526
17. Falkenberg T, Ernfors P, Persson H, Lindefors N (1992) Cortical transynaptic activation of tyrosine kinase receptor trkB messenger RNA expression in rat hippocampus. Neuroscience 51:883-889
18. GFRα Nomenclature Committee (1997) Nomenclature of GPI-linked receptors for members of the GDNF ligand family. Neuron 19:485
19. Greco A, Mariani C, Miranda C, Pagliardini S, Pierotti MA (1993) Characterization of the NTRK1 genomic region involved in chromosomal rearrangements generating TRK oncogenes. Genomics 18:397-400
20. Greene LA (1977) Quantitative in vitro studies on the nerve growth factor requirement of neurons. I. Sympathetic neurons. Devel Biol 58:96-105
21. Henderson CE, Phillips HS, Pollock RA, Davies AM, Lemeulle C, Armanini M, Simmons L, Moffet B, Vandlen RA, Simpson LC (1994) GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266:1062-1064
22. Heumann R, Korsching S, Scott J, Thoenen H (1984) Relationship between levels of nerve growth factor (NGF) and its messenger RNA in sympathetic ganglia and peripheral target tissues. EMBO J 3:3183-3189
23. Hohn A, Leibrock J, Bailey K, Barde YA (1990) Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 344:339-341
24. Jacobson M (1991) Developmental neurobiology, 3rd edn. Plenum Press, New York
25. Jing S, Wen D, Yu Y, Holst PL, Luo Y, Fang M, Tamir R, Antonio L, Hu Z, Cupples R, Louis JC, Hu S, Altrock BW, Fox GM (1996) GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Cell 85:1113-1124
26. Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM (1997) GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. J Biol Chem 272:33111-33117
27. Klein R, Conway D, Parada LF, Barbacid M (1990) The trKB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell 61:647-656
28. Klein RD, Sherman D, Ho WH, Stone D, Bennett GL, Moffat B, Vandlen R, Simmons L, Gu Q, Hongo JA, Devaux B, Poulsen K, Armanini M, Nozaki C, Asai N, Goddard A, Phillips H, Henderson CE, Takahashi M, Rosenthal A (1997) A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Nature 387:717-721
29. Kotzbauer PT, Lampe PA, Heuckeroth RO, Golden JP, Creedon DJ, Johnson EM, Milbrandt J (1996) Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature 384: 467-470
30. Lamballe F, Tapley P, Barbacid M (1993) trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities. EMBO J 12:3083-3094
31. Lanzi C, Borrello MG, Bongarzone I, Migliazza A, Fusco A, Grieco M, Santoro M, Gambeta RA, Zumina F, Della Porta G, Pierotti MA (1992) Identification of the product of two oncogenic re-arranged forms of the RET proto-oncogene in papillary thyroid carcinomas. Oncogene 7:1189-1194
32. Lin L-FH, Doherty D, Lile J, Bektesh S, Collins F (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260:1130-1132
33. Maisonpierre PC, Belluscio L, Friedman B, Alderson RF, Wiegand SJ, Furth ME, Lindsay RM, Yancopoulos GD (1990) NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron 5:501-509
34. Martin Zanca D, Oskam R, Mitra G, Copeland T, Barbacid M (1989) Molecular and biochemical characterization of the human trk proto-oncogene. Mol Cell Biol 9:24-33
35. Merlio JP, Ernfors P, Jaber M, Persson H (1992) Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system. Neuroscience 51:513-532
36. Middlemas DS, Lindberg RA, Hunter T (1991) trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Mol Cell Biol 11:143-153
37. Milbrandt J, de Sauvage FJ, Fahrner TJ, Baloh RH, Leitner ML, Tansey MG, Lampe PA, Heuckeroth RO, Kotzbauer PT, Simburger KS, Golden JP, Davies JA, Vejsada R, Kato AC, Hynes M, Sherman D, Nishimura M, Wang LC, Vandlen R, Moffat B, Klein RD, Poulsen K, Gray C, Garces A, Johnson EM Jr (1998) Persephin, a novel neurotrophic factor related to GDNF and neurturin. Neuron 20:245-253
38. Moore MW, Klein RD, Farinas, IX, Sauer H, Armanini M, Phillips H, Reichardt LF, Ryan AM, Carver-Moore K, Rosenthal A (1996) Renal and neuronal abnormalities in mice lacking GDNF. Nature 382:76-79
39. Pachnis V, Mankoo B, Costantini F (1993) Expression of the c-ret proto-oncogene during mouse embryogenesis. Development 119:1005-1017
40. Pasini B, Ceccherini I, Romeo G (1996) ret mutations in human disease. Trends Genet 12:138-144
41. Pichel JG, Shen L, Sheng HZ, Granholm AC, Drago J, Grinberg A, Lee EJ, Huang SP, Saarma M, Hoffer BJ, Sariola H, Westphal H (1996) Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 382:73-76
42. Robertson K, Mason I (1997) The GDNF-RET signalling partnership. Trends Genet 13:1-3
43. Rosenthal A, Goeddel DV, Nguyen T, Lewis M, Shih A, Laramee GR, Nikolics K, Winslow JW (1990) Primary structure and biological activity of a novel human neurotrophic factor. Neuron 4:767-773
44. Sanchez MP, Silos-Santiago, IX, Frisen J, He B, Lira SA, Barbacid M (1996) Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 382:70-73
45. Sanicola M, Hession C, Worley D, Carmillo P, Ehrenfels C, Walus L, Robinson S, Jaworski G, Wei H, Tizard R, Whitty A, Pepinsky RB, Cate RL (1997) Glial cell line-derived neurotrophic factor-dependent ret activation can be mediated by two different cell-surface accessory proteins. Proc Nat Acad Sci USA 94:6238-6243
46. Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V (1994) Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 367:380-383
47. Schuchardt A, Srinivas S, Pachnis V, Costantini F (1995) Isolation and characterization of a chicken homolog of the c-ret protooncogene. Oncogene 10:641-649
48. Shelton DL, Reichardt LF (1984) Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs. Proc Natl Acad Sci USA 81:7951-7955
49. Snider WD (1994) Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 77:627-638
50. Stern JE, Sarmiento MI, Cardinali DP (1994) Parasympathetic control of parathyroid hormone and calcitonin secretion in rats. J Auton Nerv Syst 48:45-53
51. Suvanto P, Wartiovaara K, Lindhal M, Arumäe U, Moshnyakov M, Horelli-Kuitunen N, Airaksinen MS, Palotie A, Sariola H, Saarma M (1997) Clonong, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor β, a homologue to GDNFR-α. Hum Mol Gen 6:1267-1273
52. Thoenen H (1991) The changing scene of neurotrophic factors. Trends Neurosci 14:165-170
53. Thompson J, Doxakis E, Pinon LGP, Strachan P, Buj-Bello A, Wyatt S, Buchman VL, Davies AM (1998) GFRalpha-4, a new GDNF family receptor. Mol Cell Neurosci 11:117-126
54. Timmusk T, Belluardo N, Metsis M, Persson H (1993) Widespread and developmentally regulated expression of neurotrophin-4 mRNA in rat brain and peripheral tissues. Eur J Neurosci 5:605-613
55. Tomac A, Lindqvist E, Lin LF, Ogren SO, Young D, Hoffer BJ, Olson L (1995) Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373:335-339
56. Treanor J, Goodman L, Desauvage F, Stone DM, Poulsen KT, Beck CD, Gray C, Armanini MP, Pollock RA, Hefti F, Phillips HS, Goddard A, Moore MW, Buj Bello A, Davies AM, Asai N, Takahashi M, Vandlen R, Henderson CE, Rosenthal A (1996) Characterization of a multicomponent receptor for GDNF. Nature 382:80-83
57. Trupp M, Rydén M, Jörnvall H, Timmusk T, Funakoshi H, Arenas E, Ibáñez CF (1995) Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. J Cell Biol 130:137-148
58. Trupp M, Arenas E, Fainzilber M, Nilsson AS, Sieber BA, Grigoriou M, Kilkenny C, Salazar-Grueso E, Pachnis V, Arumae U, Sariola H, Saarma M, Ibanez CF (1996) Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature 381:785-788
59. Trupp M, Belluardo N, Funakoshi H, Ibanez CF (1997) Complementary and overlapping roles of GDNF, RET and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS. J Neurosci 17:3554-3567
60. Tsoulfas P, Soppet D, Escandon E, Tessarollo L, Mendoza Ramirez JL, Rosenthal A, Nikolics K, Parada LF (1993) The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells. Neuron 10:975-990
61. Tsuzuki T, Takahashi M, Asai N, Iwashita T, Matsuyama M, Asai J (1995) Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues. Oncogene 10:191-198
62. Valenzuela DM, Maisonpierre PC, Glass DJ, Rojas E, Nunez L, Kong Y, Gies DR, Stitt TN, Ip NY, Yancopoulos GD (1993) Alternative forms of rat TrkC with different functional capabilities. Neuron 10:963-974
63. Widenfalk J, Nosrat C, Tomac A, Westphal H, Hoffer B, Olson L (1997) Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs. J Neurosci 17:8506-8519