The mechanism of N-acetylcysteine photoprotection is not related to dipyrimidine photoproducts

Journal of Photochemistry and Photobiology B: Biology

Volumn 44, Issue 3, 1998, Pages 225-230

  Nijmeijer, Bart A ^a   Steenvoorden, David P T ^a   Beijersbergen Van Henegouwen, Gerard M J ^a   Roza, Len ^b   Vink, Arie A ^b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b TNO   (Netherlands)

Author keywords

DNA damage; Immunosuppression; Photoprotection

Indexed keywords

ACETYLCYSTEINE; CYCLOBUTANE; PYRIMIDINE DIMER; UROCANIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONTACT ALLERGY; DNA DAMAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ULTRAVIOLET B RADIATION;

ACETYLCYSTEINE; ANIMALS; DNA DAMAGE; EPIDERMIS; GLUTATHIONE; MALE; MICE; MICE, INBRED BALB C; PYRIMIDINES; ULTRAVIOLET RAYS;

ANIMALIA;

EID: 0032584476     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1011-1344(98)00148-1     Document Type: Article

References (34)

1. [1] O.I. Aruoma, B. Haliwell, B.M. Hoey, J. Butter, The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid, Free Radical. Biol. and Med. 6 (1989) 593-597.
2. [2] D.P.T. Steenvoorden, D.M. Hasselbaink, G.M.J. Beijersbergen Van Henegouwen, Protection against UV-induced reactive intermediates in human cells and mouse skin by glutathione precursors; a comparison of N-acetylcysteine and glutathione ethylester, Photochem. Photobiol. 67 (1998) 651-656.
3. [3] S. Bannai, N. Tateishi, Role of membrane transport in metabolism and function of glutathione in mammals, J. Membrane. Biol. 89 (1986) 1-8.
4. [4] I.A. Cotgreave, N-Acetylcysteine: pharmacological considerations and experimental and clinical applications, Adv. Pharmacol. 38 (1997) 205-227.
5. [5] L.T. Van Den Broeke, G.M.J. Beijersbergen Van Henegouwen, Thiols as potential UV radiation protectors: an in vitro study, J. Photochem. Photobiol. B: Biol. 17 (1993) 279-286.
6. [6] L.T. Van Den Brocke, G.M.J. Beijersbergen Van Henegouwen, UV radiation protecting efficacy of cysteine derivatives, studies with UVA-induced binding of 8-MOP and CPZ to rat epidermal biomacromolecules in vivo, Int. J. Radiat. Biol. 67 (1994) 411-420.
7. [7] L.T. Van Den Broeke, G.M.J. Beijersbergen Van Henegouwen, Topically applied N-acetylcysteine as a protector against UVB-induced systemic immune suppression, J. Photochem. Photobiol. B: Biol. 27 (1995) 61-65.
8. [8] P.J. Hemelaar, G.M.J. Beijersbergen Van Henegouwen, The protective effect of N-acetylcysteine on UVB-induced immimosuppression by inhibition of the action of urocanic acid, Photochem. Photobiol. 63 (1996) 322-327.
9. [9] E.C. De Fabo, F.P. Noonan, Mechanism of immune suppression by ultraviolet irradiation in vivo. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology, J. Exp. Med. 157 (1983) 84-98.
10. [10] F.P. Noonan, E.C. De Fabo, Immunosuppression by ultraviolet B radiation: initiation by urocanic acid, Immunology Today 13 (1992) 250-254.
11. [11] L.A. Applegate, R.D. Ley, J. Alcalay, M.L. Kripke, Identification of the molecular target for the suppression of contact hypersensitivity by ultraviolet radiation, J. Exp. Med. 170 (1989) 1117-1131.
12. [12] M.L. Kripke, P.A. Cox, L.G. Alas, D.B. Yarosh, Pyrimidine dimers in DNA initiate systemic immune suppression in UV irradiated mice, Proc. Natl. Acad. Sci. USA 89 (1992) 7516-7520.
13. [13] A.A. Vink, D.B. Yarosh, M.L. Kripke, Chromophore for UV-induced immunosuppression: DNA, Photochem. Photobiol. 63 (1996) 383-386.
14. [14] A.A. Vink, F.M. Strickland, C.D. Bucana, L. Roza, D.B. Yarosh, M.L. Kripke, The inhibition of antigen-presenting activity of dendritic cells resulting from UV irradiation of murine skin is restored by in vitro photorepair of cyclobutane pyrimidine dimers, Proc. Natl. Acad. Sci. USA 94 (1997) 5255-5260.
15. [15] C. Nishigori, D.B. Yarosh, S.E. Ullrich, A.A. Vink, C.D. Bucana, L. Roza, M.L. Kripke, DNA damage triggers IL-10 production in UV-irradiated keratinocytes, Proc. Natl. Acad. Sci. USA 93 (1996) 10354-10359.
16. [16] J. Cadet, P. Vigny, The photochemistry of nucleic acids, in: H. Morrison (Ed.), Bioorganic Photochemistry: Photochemistry and the Nucleic Acids, vol. 1, John Wiley, New York, 1989, pp. 60-63.
17. [17] L. Roza, K.J.M. Van der Wulp, S.J. MacFarlane, P.H.M. Lohman, R.A. Baan, Detection of cyclobutane thymine dimers in DNA of human cells with monoclonal antibodies raised against a thymine dimer-containing tetranucleotide, Photochem. Photobiol. 46 (1988) 627-634.
18. [18] T. Mori, M. Nakane, T. Hattori, T. Matsunaga, M. Ihara, O. Nikaido, Simultaneous establishment of monoclonal antibodies specific for either cyclobutane pyrimidine dimer or (6-4) photoproduct from the same mouse immunized with ultraviolet-irradiated DNA, Photochem. Photobiol. 54 (1991) 225-232.
19. [19] P. Boukamp, R.T. Petrussevska, D. Breitkreuz, J. Hornung, A. Markham, N. Fusenig, Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line, J. Cell. Biol. 106 (1988) 761-771.
20. [20] D.P.T. Steenvoorden, G.M.J. Beijersbergen Van Henegouwen, Cysteine derivatives protect against UV-induced reactive intermediates in human keratinocytes: the role of glutathione synthesis, Photochem. Photobiol. 66 (1998) 665-671.
21. [21] L.T. Van Den Broeke, G.M.J. Beijersbergen Van Henegouwen, The effect of N-acetylcysteine on the UVB-induced inhibition of epidermal DNA synthesis in rat skin, J. Photochem. Photobiol. B: Biol. 26 (1994) 271-276.
22. [22] G. Caceres-Dittmar, K. Ariizumi, S. Xu, F.J. Tapia, P.R. Bergstresser, Hydrogen peroxide mediates UV-induced impairment of antigen presentation in a murine epidermal-derived dendritic cell line, Photochem. Photobiol. 62 (1995) 176-183.
23. [23] M.M. Simon, Y. Aragane, A. Schwartz, T.A. Luger, T. Schwanz, UVB light induces nuclear factor κB (NfκB) activity independently from chromosomal DNA damage in cell free cytosolic extracts, J. Invest. Dermatol. 102 (1994) 422-427.
24. [24] G.F. Vile, A. Tanew-Iliitschew, R.M. Tyrrell, Activation of NF-κB in human skin tibroblasts by the oxidative stress generated by UVA radiation, Photochem. Photobiol. 62 (1995) 463-468.
25. [25] K. Valene, W.S. Laster, L. Cheng, J.C. Kirkham, P. Reavey, N.C. Kuemmerle, Signal transduction and HIV transcriptional activation after exposure to ultraviolet light and other DNA-damaging agents, Photochem. Photobiol. 64 (1996) 280-285.
26. [26] S.C. Miller, A. Taylor, K. Watanabe, K. Mok, F.M. Torti, Regulation of NFκB and HIV-1 LTR activity in mouse L cells by ultraviolet radiation: LTR trans-activation in a nonirradiated genome in heterokaryons, Exp. Cell Res. 230 (1997) 9-21.
27. [27] M.J. Lenardo, D. Baltimore, NF-κB: a pleiotropic mediator of inducible and tissue-specific gene control, Cell 58 (1989) 227-229.
28. [28] K.S. Ullman, J.P. Northrop, C.L. Verweij, G.R. Crabtree, Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link, Ann. Rev. Immunol. 8 (1990) 421-452.
29. [29] P. Redondo, M.L. Subira, N-acetylcysteine inhibits production of tumor necrosis factor α and interleukin-1β, Arch. Intern. Med. 156 (1996) 1238-1241.
30. [30] A.M. Moodycliffe, C.D. Bucana, M.L. Kripke, M. Norval, S.E. Ullrich, Differential effects of a monoclonal antibody to cis-urocanic acid on the suppression of delayed and contact hypersensitivity following ultraviolet irradiation, J. Immunol. 157 (1996) 2891-2899.
31. [31] A.A. El-Ghorr, M. Norval, A monoclonal antibody to cis-urocanic acid prevents the ultraviolet-induced changes in Langerhans cells and delayed type hypersensitivity in mice, although not preventing dendritic cell accumulation in lymph nodes draining the site of irradiation and contact hypersensitivity, J. Invest. Dermatol. 105 (1995) 264-268.
32. [32] S. Kondo, D.N. Sauder, R.C. McKenzie, H. Fujisawa, G.M. Shivji, A. El-Ghorr, M. Norval, The role of cis-urocanic acid in UVB-induced suppression of contact hypersensitivity, Immunology Lett. 48 (1995) 181-186.
33. [33] P.H. Hart, A. Jaksic, G. Swift, M. Norval, A.A. El-Ghorr, J.J. Finlay-Jones, Histamine involvement in UVB-and cis-urocanic acid-induced systemic suppression of contact hypersensitivity responses, Immunology 91 (1997) 601-608.
34. [34] I. Kurimoto, J.W. Streilein, Cis-urocanic acid suppression of contact hypersensitivity induction is mediated via tumor necrosis factor, J. Immunol. 148 (1992) 3072-3078.