Deficient cancellation of the vestibular ocular reflex in schizophrenia

Schizophrenia Research

Volumn 34, Issue 3, 1998, Pages 187-193

  Warren, Sarah ^a   Ross, Randal G ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Eye movements; Schizophrenia; Smooth pursuit; Vestibulo ocular reflex

Indexed keywords

CHLORPROMAZINE; NEUROLEPTIC AGENT;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EYE TRACKING; FEMALE; GAZE; HUMAN; MALE; PRIORITY JOURNAL; ROTATION; SACCADIC EYE MOVEMENT; SCHIZOPHRENIA; SMOOTH PURSUIT EYE MOVEMENT; TASK PERFORMANCE; VESTIBULOOCULAR REFLEX;

ADULT; EYE MOVEMENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; REFLEX, VESTIBULO-OCULAR; SCHIZOPHRENIA;

EID: 0032583086     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(98)00101-7     Document Type: Article

References (35)

1. Abel, L., Ziegler, A., 1988. Smooth pursuit eye movements in schizophrenics - What constitutes quantitative assessment? Biol. Psychiatry 24, 747-761.
2. American Psychiatric Association, 1994. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association Press, Washington, DC.
3. Andreason, N.C., O'Leary, D.S., Cizadio, T., Arndt, S., Rezai, K., Ponto, L.L., Watkins, G.L., Hichwa, R.D., 1996. Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proc. Natl. Acad. Sci. 93, 9985-9990.
4. Blackwood, D.H.R., St. Clair, D.M., Muir, W.J., Duffy, J.C., 1991. Auditory P300 and eye tracking dysfunction in schizophrenic pedigrees. Arch. Gen. Psychiatry 48, 899-909.
5. Boman, D., Braun, D., Hotson, J., 1996. Stationary and pursuit visual fixation shore similar behavior. Vision Res. 36, 751-763.
6. Clementz, B.A., Sweeney, J.A., 1990. Is eye movement dysfunction a biological marker for schizophrenia: A methodological review. Psychol. Bull. 108, 77-92.
7. Clementz, B.A., Grove, W.M., Iacono, W.G., Sweeney, J.A., 1992. Smooth-pursuit eye movement dysfunction and liability for schizophrenia: Implications for genetic modeling. J. Abnorm. Psychol. 101, 117-129.
8. Clementz, B.A., Reid, S.A., McDowell, J.E., Cadenhead, K.S., 1995. Abnormality of smooth pursuit eye movement initiation: Specificity to the schizophrenia spectrum? Psychophysiology 32, 130-134.
9. Couch, R.H., Cox, J.C., 1934. Photographic study of ocular movements in mental disease. Arch. Neurol. Psychiatry 34, 556-578.
10. Cullen, K.E., Chen-Huang, C., McCrea, R.A., 1993. Firing behavior of brain stem neurons during voluntary cancellation of horizontal vestibuloocular reflex: II. Eye movement related neurons. J. Neurophysiol. 70, 844-856.
11. Diefendorf, A.R., Dodge, R., 1908. An experimental study of the ocular reaction on the insane from photographic records. Brain 31, 451-489.
12. Holzman, P.S., Proctor, L.R., Hughes, D.W., 1973. Eye tracking patterns in schizophrenia. Science 181, 179-181.
13. Hommer, D.W., Radant, A.D., Peng, C., 1991. Oculomotor delayed response tasks in schizophrenia: evidence for prefrontal cortex dysfunction. Soc. Neurosci. Abstracts (abstract) 17, 354
14. Iacono, W.G., Moreau, M., Beiser, M., Fleming, J.A.E., Lin, T.Y., 1992. Smooth-pursuit eye tracking in first-episode psychotic patients and their relatives. J. Abnorm. Psychol. 101, 104-116.
15. Ito, M., Jastreboff, P.J., Miyashita, Y., 1982. Specific effects of unilateral lesions in the flocculus upon eye movements in albino rabbits. Exp. Brain Res. 45, 233-242.
16. Krauzlis, R.J., Miles, F.A., 1996. Initiation of saccades during fixation or pursuit: evidence in humans for a single mechanism. J. Neurophysiol. 76, 4175-4179.
17. Leigh, R.J., Zee, D.S., 1989. The Neurology of Eye Movements. F.A. Davis Company, Philadelphia, PA.
18. Levin, S., 1984. Frontal lobe dysfunction in schizophrenia. I. Eye movement impairments. J. Psychiatric Res. 18, 27-55.
19. Levy, D.L., Holzman, P.S., Matthysse, S., Mendell, N.R., 1993. Eye dysfunction and schizophrenia: A critical review. Schizophr. Res. 19, 461-536.
20. Levy, D.L., Holzman, P.S., Matthysse, S., Mendell, N.R., 1994. Eye tracking and schizophrenia: a selective review. Schizophr. Bull. 20, 47-62.
21. Mather, J.A., Putchat, C., 1983. Motor control of schizophrenics. I. Oculomotor conotrol of schizophrenics: A deficit in sensory processing, not strictly in motor control. J. Psychiatr. Res. 17, 343-360.
22. Radant, A.D., Hommer, D.W., 1992. A quantitative analysis of saccades and smooth pursuit during visual pursuit tracking: A comparison of schizophrenics with normals and substance abusing controls. Schizophr. Res. 6, 225-235.
23. Radant, A.D., Claypoole, K., Wingerson, D.K., Cowley, D.S., Roy-Byrne, P.P., 1997. Relationships between neuropsychological and oculomotor measures in schizophrenia patients and normal controls. Biol. Psychiatry 42, 797-805.
24. Ron, S., Robinson, D.A., 1973. Eye movements evoked by cerebellar stimulation in the alert monkey. J. Neurophysiol. 36, 1004-1022.
25. Rosenberg, D.R., Sweeney, J.A., Squires-Wheeler, E., Keshavan, M.S., Cornblatt, B.A., Erlenmeyer-Kimling, L., 1997. Eye tracking dysfunction in offspring from the New York High Risk Project: diagnostic specificity and the role of attention. Psychiatry Res. 66, 121-130.
26. Ross, R.G., Radant, A.D., Hommer, D.W., 1993. A developmental study of smooth pursuit eye movements in normal children from 7 to 15 years of age. J. Am. Acad. Child Adolesc. Psychiatry 32, 783-791.
27. Ross, R.G., Hommer, D.W., Radant, A.D., Roath, M., Freedman, R., 1996. Early expression of smooth pursuit eye movement abnormalities in children of schizophrenic parents. J. Am. Acad. Child Adolesc. Psychiatry 35, 941-949.
28. Ross, R.G., Harris, J.G., Olincy, A., Radant, A.D., Adler, L.E., Freedman, R., 1998. Familial transmission of two independent saccadic abnormalities in schizophrenia. Schizophr. Res. 30, 59-70.
29. Ross, R.G., Olincy, A., Harris, J.G., Radant, A.D., Adler, L.E., Freedman, R., in press. Anticipatory saccades during smooth pursuit eye movements and familial transmission of schizophrenia. Biol. Psychiatry.
30. Steinberg, J.L., Devous, M.D.S., Moeller, F.G., Paulman, R.G., Raese, J.D., Gregory, R.R., 1995. Cerebellar blood flow in schizophrenia patients and normal control subjects. Psychiatry Res. 61, 15-31.
31. Van den Bosch, R.J., 1984. Eye tracking impairment: Attentional and psychometric correlates in psychiatric patients. J. Psychiatr. Res. 18, 227-286.
32. Volkow, N.D., Levy, A., Brodie, J.D., Wolf, A.P., Cancro, R., Van Gelder, P., Henn, R., 1992. Low cerebellar metabolism in medicated patients with chronic schizophrenia. Am. J. Psychiatry 149, 686-688.
33. Waterston, J.A., Barnes, G.R., Grealy, M.A., Collins, S., 1996. Abnormalities of smooth eye and head movement control in Parkinson's disease. Ann. Neurol. 39, 749-760.
34. Whicker, L., Abel, L.A., Dell'Osso, L.F., 1985. Smooth pursuit eye movements in the parents of schizophrenics. Neuroophthalmology 5, 1-8.
35. Yee, R.D., Baloh, R.W., Marder, S.R., Levy, D.L., Sakala, S.M., Honrubia, V., 1987. Eye movements in schizophrenia. Invest. Ophthalmol. Visual Sci. 28, 366-374.