Early expression of smooth-pursuit eye movement abnormalities in children of schizophrenic parents

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 35, Issue 7, 1996, Pages 941-949

  Ross, Randal G ^a,d   Hommer, Daniel ^b   Radant, Allen ^c   Roath, Margaret ^a   Freedman, Robert ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d Box C268 71 ^*  (United States)

Author keywords

at risk; children; endophenotype; eye movements; schizophrenia; smooth pursuit

Indexed keywords

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; FAMILY HISTORY; FEMALE; GENETIC SUSCEPTIBILITY; HUMAN; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SACCADIC EYE MOVEMENT; SCHIZOPHRENIA;

EID: 0029901841     PISSN: 08908567     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004583-199607000-00022     Document Type: Article

References (53)

1. Abel L, Friedman L, Jesberger J, Malki A, Meltzer HY (1991), Quantitative assessment of smooth pursuit gain and catch-up saccades in schizophrenia and affective disorders. Biol Psychiatry 29:1063-1072
2. Abel L, Ziegler A (1988), Smooth pursuit eye movements in schizophrenics: what constitutes quantitative assessment? Biol Psychiatry 24:747-761
3. American Psychiatric Association (1987), Diagnostic and Statistical Manual of Mental Disorders, 3rd edition-revised (DSM-III-R). Washington, DC: American Psychiatric Association
4. Bahill AT, Clark MR, Stark L (1975), The main sequence, a tool for studying human eye movements. Math Biosci 24:191-204
5. Blackwood DHR, St Clair DM, Muir WJ, Duffy JC (1991), Auditory P300 and eye tracking dysfunction in schizophrenic pedigrees. Arch Gen Psychiatry 48:899-909
6. Bon L, Lucchetti C (1992), The dorsomedial frontal cortex of the macaca monkey: fixation and saccade-related activity. Exp Brain Res 89:571-580
7. Clementz BB, Grove WM, Iacono WG, Sweeney JA (1992), Smooth-pursuit eye movement dysfunction and liability for schizophrenia: implications for genetic modeling. J Abnorm Psychol 101:117-129
8. Clementz BB, Sweeney JA (1990), Is eye movement dysfunction a biological marker for schizophrenia? A methodological review. Psychol Bull 108:77-92
9. Clementz BB, Sweeney JA, Hirt M, Haas G (1990), Pursuit gain and saccadic intrusions in first-degree relatives of probands with schizophrenia. J Abnorm Psychol 99:327-335
10. Couch RH, Cox JC (1934), Photographic study of ocular movements in mental disease. Arch Neurol Psychiatry 34:556-578
11. Diefendorf AR, Dodge R (1908), An experimental study of the ocular reaction on the insane from photographic records. Brain 31:451-489
12. Endicott J, Spitzer RL (1978), A diagnostic interview: the Schedule for Affective Disorders and Schizophrenia. Arch Gen Psychiatry 35:837-844
13. Erlenmeyer-Kimling L (1987), Biological markers for the liability to schizophrenia. In: Biological Perspectives of Schizophrenia, Helmchen H, Henn FA, eds. S. Chichester, England: John Wiley & Sons Limited, pp 33-56
14. Friedman L, Jesberger JA, Meltzer HY (1991), A model of smooth pursuit performance illustrates the relationship between gain, catch-up saccade rate, and catch-up saccades amplitude in normal controls and patients with schizophrenia. Biol Psychiatry 30:537-556
15. Friedman L, Jesberger JA, Meltzer HY (1992), Effect of typical antipsychotic medication and clozapine on smooth pursuit performance in patients with schizophrenia. Psychiatry Res 41:25-36
16. Gottesman II, Bertelsen A (1989), Confirming unexpressed genotypes for schizophrenia. Arch Gen Psychiatry 46:867-872
17. Grove WM, Clementz BA, Iacono WG, Katsanis J (1992), Smooth pursuit ocular motor dysfunction in schizophrenia: evidence for a major gene. Am J Psychiatry 149:1362-1368
18. Grove WM, Lebow BS, Clementz BA, Cerri A, Medus C, Iacono WG (1991), Familial prevalence and coaggregation of schizotypy indicators: a multitrait family study. J Abnorm Psychol 100:115-121
19. Hikosaka O, Masahiro M, Miyashita N (1993), Effects of caudate nucleus stimulation on substantia nigra cell activity in monkey. Exp Brain Res 95:457-472
20. Holzman PS (1989), The use of eye movement dysfunctions in exploring the genetic transmission of schizophrenia. Eur Arch Psychiatr Neurol Sci 239:43-48
21. Holzman PS, Kringlen E, Levy DL, Haberman SJ (1980), Deviant eye tracking in twins discordant for schizophrenia. Arch Gen Psychiatry 37:627-631
22. Holzman PS, Kringlen E, Matthysse S et al. (1988), A single dominant gene can account for eye tracking dysfunction and schizophrenia in offspring of discordant twins. Arch Gen Psychiatry 45:641-647
23. Holzman PS, Proctor LR, Hughes DW (1973), Eye tracking patterns in schizophrenia. Science 181:179-181
24. Holzman PS, Solomon CM, Levin S, Waternaux CS (1984), Pursuit eye movement dysfunctions in schizophrenia. Arch Gen Psychiatry 41:136-139
25. Iacono WG, Lykken DT (1979a), Eye tracking and psychopathology. Arch Gen Psychiatry 36:1361-1369
26. Iacono WG, Lykken DT (1979b), Electo-oculographic recording and scoring of smooth pursuit and saccadic eye tracking: a parametric study using monozygotic twins. Psychophysiology 16:94-107
27. Iacono WG, Moreau M, Beiser M, Fleming JAE, Lin TY (1992), Smooth-pursuit eye tracking in first-episode psychotic patients and their relatives. J Abnorm Psychol 101:104-116
28. Keefe RSE, Siever LJ, Mohs RC et al. (1989), Eye tracking, schizophrenic symptoms, and schizotypal personality disorder. Eur Arch Psychiatr Neurol Sci 239:39-42
29. Levy DL, Holzman PS, Matthysse S, Mendell NR (1993), Eye tracking dysfunction and schizophrenia: a critical perspective. Schizophr Res 19:461-536
30. Levy DL, Yasillo NJ, Dorus E et al. (1983), Relatives of unipolar and bipolar patients have normal pursuit. Psychiatry Res 10:285-293
31. Litman RE, Hommer DW, Radant A, Clem T, Pickar D (1994), Quantitative effects of typical and atypical neuroleptics on smooth pursuit eye tracking in schizophrenia. Schizophr Res 12:107-120
32. Marcus J, Hans SL, Auerbach JG, Mirsky AF, Aubrey A (1987), Review of the NIMH Israeli Kibbutz-City Study and the Jerusalem Infant Development Study. Schizophr Bull 13:425-438
33. Mather JA (1985), Eye movements of teenage children of schizophrenics: a possible inherited marker of susceptibility to the disease. J Psychiatr Res 19:523-532
34. Matsumura M, Kojima J, Gardiner TW, Hikosaka O (1992), Visual and oculomotor functions of monkey subthalamic nucleus. J Neurophysiol 67:1615-1631
35. Mednick SA (1970), Breakdown in individuals at high risk for schizophrenia: possible predispositional perinatal factors. Ment Hyg 54:50-63
36. Munoz DP, Wurtz RH (1993), Fixation cells in monkey superior colliculus II. Reversible activation and deactivation. J Neurophysiol 20:576-589
37. O'Driscoll GA, Alpert NM, Matthysse SW, Levy DL, Rauch SL, Holzman PS (1995), Functional neuroanatomy of antisaccade movements investigated with positron emission tomography. Proc Natl Acad Sci USA 92:925-929
38. Pass HL, Salzman LF, Klorman R, Kaskey GB, Klein RH (1978), The effect of distraction on acute schizophrenics' visual tracking. Biol Psychiatry 13:587-593
39. Radant AD, Hommer DW (1992), A quantitative analysis of saccades and smooth pursuit during visual pursuit tracking: a comparison of schizophrenics with normals and substance abusing controls. Schizophr Res 6:225-235
40. Rieder RO, Nichols PL (1979), Offspring of schizophrenics III: hyperactivity and neurological soft signs. Arch Gen Psychiatry 36:665-674
41. Ross RG, Harris J, Cullum CM et al. (1994), Smooth pursuit eye movements in parents of probands with schizophrenia: an obligate carrier approach. Soc Neurosci Abstr 20:1262
42. Ross RG, Radant AD, Hommer DW (1993), A developmental study of smooth pursuit eye movements in normal children from 7 to 15 years of age. J Am Acad Child Adolesc Psychiatry 32:783-791
43. Rund BR, Landro NI (1990), Information processing: a new model for understanding cognitive disturbances in psychiatric patients. Acta Psychiatr Scand 81:305-316
44. Salzman LF, Klein RH, Strauss JS (1978), Pendulum eye-tracking in remitted psychiatric patients. J Psychiatr Res 14:121-126
45. Schulsinger H (1976), A ten-year follow-up of children of schizophrenic mothers. Acta Psychiatr Scand 53:371-386
46. Siever LJ, Haier RJ, Coursey RD et al. (1982), Smooth pursuit eye tracking impairment. Arch Gen Psychiatry 39:1001-1005
47. Siever LJ, Keefe R, Bernstein DP et al. (1990), Eye tracking impairment in clinically identified patients with schizotypal personality disorder. Am J Psychiatry 147:740-745
48. Spitzer RL, Williams JBW, Gibbon M, First MB (1990), Structured Clinical Interview for DSM-III-R-Patient Edition. Washington, DC: American Psychiatric Press
49. Suzuki H, Azuma M (1977), Prefrontal neuronal activity during gazing at a light spot in the monkey. Brain Res 126:497-508
50. Thurston SE, Leigh RJ, Crawford T, Thompson A, Kennard C (1988), Two distinct deficits of visual tracking caused by unilateral lesions of cerebral cortex in humans. Ann Neurol 23:266-273
51. Tienari P, Lahti I, Sorri A, Naarala M, Moring J, Wahlberg KE (1989), The Finnish adoptive family study of schizophrenia: possible joint effects of genetic vulnerability and family environment. Br J Psychiatry 155(suppl 5):29-32
52. Waldo MC, Roath M, Levine W, Freedman R (1987), A model program to teach parenting skills to schizophrenic mothers. Hosp Community Psychiatry 38:1110-1112
53. Weschler D (1991), Weschler Intelligence Scale for Children-Third Edition. San Antonio, TX: Harcourt Brace Jovanovich