Immune markers and viral load after HIV-1 seroconversion as predictors of disease progression in a cohort of haemophilic men

AIDS

Volumn 12, Issue 11, 1998, Pages 1347-1352

  Sabin, Caroline A ^a   Devereux, Helen ^a   Phillips, Andrew N ^a   Janossy, George ^a   Loveday, Clive ^a   Lee, Christine A ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

CD4+ T cell count; CD8+ T cell count; Disease progression; HIV 1 RNA; IgA; IgG; Immune response; Prognosis; Seroconversion; Viral load

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; VIRUS RNA;

ARTICLE; DISEASE COURSE; HEMOPHILIA; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; SEROCONVERSION; T LYMPHOCYTE; VIRUS LOAD;

EID: 0032581605     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199811000-00017     Document Type: Article

References (31)

1. O'Brien WA, Hartigan PM, Martin D, et al.: Changes in plasma HIV-1 RNA and CD4+ lymphocytes and the risk of progression to AIDS. N Engl J Med 1996, 334:426-431.
2. Loveday C, Hill A: Prediction of progression to AIDS with serum HIV-1 RNA and CD4 count [letter]. Lancet 1995, 345:790-791.
3. Cao Y, Qin L, Zhang L, Safrit J, Ho DD: Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med 1995, 332:201-208.
4. Pantaleo G, Menzo S, Vaccarezza M, et al.: Studies in subjects with long-term nonprogressive human immunodeficiency virus infection. N Engl J Med 1995, 332:209-216.
5. Mellors JW, Kingsley LA, Rinaldo Jr CR, et al.: Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann Intern Med 1995, 122:573-579.
6. Hogervorst E, Jurriaans S, de Wolf F, et al.: Predictors for non-and slow progression in human immunodeficiency virus (HIV) type 1 infection: low viral RNA copy numbers in serum and maintenance of high HIV-1 p24-specific but not V3-specific antibody levels. J Infect Dis 1995, 171:811-821.
7. Welles SL, Jackson JB, Yen-Lieberman B, et al.: Prognostic value of plasma human immunodeficiency virus type 1 (HIV-1) RNA levels in patients with advanced HIV-1 disease and with little or no prior zidovudine therapy. J Infect Dis 1996, 174:696-703.
8. Phillips AN, Eron JJ, Bartlett JA, et al.: HIV-1 RNA levels and the development of clinical disease. AIDS 1996, 10:859-865.
9. Mellors JW, Rinaldo Jr CR, Gupta P, White RM, Todd JA, Kingsley LA: Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 1996, 272:1167-1170.
10. Saksela K, Stevens CE, Rubinstein P, Taylor PE, Baltimore D: HIV-1 messenger RNA in peripheral blood mononuclear cells as an early marker of risk for progression to AIDS Ann Intern Med 1995, 123:641-648.
11. Daar ES, Moudgil T, Meyer RD, Ho DD: Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N Engl J Med 1991, 324:961-964.
12. Henrard DR, Daar E, Farzadegan H, et al.: Virologic and immunologic characterization of symptomatic and asymptomatic primary HIV-1 infection. J Acquir Immune Defic Syndr Hum Retrovirol 1945, 9:305-310.
13. O'Brien TR, Blattner WA, Waters D, et al.: Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study. JAMA 1996, 276:105-110
14. Henrard DR, Phillips JF, Muenz LR, et al.: Natural history of HIV-1 cell-free viremia. JAMA 1995, 274:554-558.
15. Brinchmann JE, Vartdal F, Thorshy E: T lymphocyte subset changes in human immunodeficiency virus infection. J Acquir Immune Defic Syndr 1989, 2:398-403.
16. Smith GM, McVerry BA, Cooper EH: HIV infection in the Edinburgh haemophiliac cohort [letter]. BMJ 1990, 301:1395-1396.
17. Phillips AN, Sabin CA, Elford J, Bofill M, Lee CA, Janossy C: CD8 lymphocyte counts and serum immunoglobulin A levels early in HIV infection as predictors of CD4 lymphocyte depletion during 8 years of follow-up. AIDS 1993, 7:975-980.
18. Lee CA, Phillips A, Elford J, et al.: The natural history of human immunodeficiency virus infection in a haemophilic cohort. Br J Haematol 1989, 73:228-234.
19. Lee CA, Sabin CA, Phillips AN, Elford J, Pasi J: Morbidity and mortality from transfusion-transmitted disease in haemophilia [letter]. Lancet 1995, 345:1309.
20. Mercolino TJ, Connelly MC, Meyer EJ, et al.: Immunologic differentiation of absolute lymphocyte count with an integrated flow cytometric system: a new concept for absolute T cell subset determinations. Cytometry 1995, 22:48-59.
21. Barnett D, Granger V, Mayr P, Storie I, Wilson GA, Reilly JT: Evaluation of a novel stable whole blood quality control material for lymphocyte subset analysis: result from the UK NEQAS immune monitoring scheme. Cytometry 1996, 26:216-222.
22. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958, 53:457-481.
23. Cox DR, Oakes D: Analysis of Survival Data. London: Chapman and Hall; 1984.
24. SAS Institute: SAS/STAT User's Guide, Version 6. Cary: SAS Institute; 1992.
25. Jurriaans S, van Gemen B, Weverling GJ, et al.: The natural history of HIV-1 infection: virus load and virus phenotype independent determinants of clinical course? Virology 1994, 204:223-233.
26. Farzadegan H, Henrard DR, Kleeberger CA, et al.: Virologic and serologic markers of rapid progression to AIDS after HIV-1 seroconversion. J Acquir Immune Defic Syndr Hum Retrovirol 1996, 13:448-455.
27. Lachgar A, Bizzini B: Contribution of alpha interferon (alpha IFN) to HIV-induced immunosuppression. Cell Mol Biol 1995, 41:431-437.
28. Gowda SD, Stein BS, Mohagheghpour N, Benike CJ, Engleman EG: Evidence that T cell activation is required for HIV-1 entry in CD4+ lymphocytes. J Immunol 1989, 142:773-780.
29. Stevenson M, Brichacek B, Heinzinger N, et al.: Molecular basis of cell cycle dependent HIV-1 replication. Implications for control of virus burden. Adv Exp Med Biol 1995, 374:33-45.
30. Coombs RW, Henrard DR, Mehaffey WF, et al.: Cell-free plasma human immunodeficiency virus type 1 titer assessed by culture and immunocapture-reverse transcription-polymerase chain reaction. J Clin Microbiol 1993, 31:1980-1986.
31. Halfon P, Khiri H, Gerolami V, et al.: Impact of various handling and storage conditions on quantitative detection of hepatitis C virus RNA. J Hepatol 1996, 25:307-311.