메뉴 건너뛰기




Volumn 10, Issue 8, 1996, Pages 859-865

HIV-1 RNA levels and the development of clinical disease

Author keywords

AIDS; CD4 lymphocyte count; HIV RNA; Viral load

Indexed keywords

ANTIVIRUS AGENT; CD4 ANTIGEN; LAMIVUDINE; VIRUS RNA; ZIDOVUDINE;

EID: 0029899473     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199607000-00009     Document Type: Article
Times cited : (69)

References (45)
  • 1
    • 0027410369 scopus 로고
    • High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR
    • PiatakM, Saag MS, Yang LC, et al:. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 1995, 259:1749-1754.
    • (1995) Science , vol.259 , pp. 1749-1754
    • Piatak, M.1    Saag, M.S.2    Yang, L.C.3
  • 2
    • 0024805742 scopus 로고
    • Quantitation of HIV-1 in the blood of infected persons
    • Ho DD, Moudgil T, Alam M: Quantitation of HIV-1 in the blood of infected persons. N Engl J Med 1989, 321:1621-1625.
    • (1989) N Engl J Med , vol.321 , pp. 1621-1625
    • Ho, D.D.1    Moudgil, T.2    Alam, M.3
  • 4
    • 0026008669 scopus 로고
    • Direct measurement of viraemia in patients infected with HIV-1 and its relationship to disease progression and zidovudine therapy
    • Semple M, Loveday C, Weller I, Tedder R: Direct measurement of viraemia in patients infected with HIV-1 and its relationship to disease progression and zidovudine therapy. J Med Vir0l 1991, 35:38-45.
    • (1991) J Med Vir0l , vol.35 , pp. 38-45
    • Semple, M.1    Loveday, C.2    Weller, I.3    Tedder, R.4
  • 5
    • 0028964251 scopus 로고
    • Prediction of progression to AIDS with serum HIV-1 RNA and CD4 count
    • Loveday C, HilJ A: Prediction of progression to AIDS with serum HIV-1 RNA and CD4 count, lancet 1995, 345:790-791.
    • (1995) Lancet , vol.345 , pp. 790-791
    • Loveday, C.1    Hilj, A.2
  • 6
    • 0029081506 scopus 로고
    • Natural history of HIV-1 cell-free viraemia
    • Henrard DR, Phillips JF, Muenz LR, et al.: Natural history of HIV-1 cell-free viraemia. JAMA 1995,274:554-558.
    • (1995) JAMA , vol.274 , pp. 554-558
    • Henrard, D.R.1    Phillips, J.F.2    Muenz, L.R.3
  • 7
    • 0028909872 scopus 로고
    • Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion
    • Mellors JW, Kingsley LA, Rinaldo CR, et aJ.: Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann Intern Med 1995, 122:573-579.
    • (1995) Ann Intern Med , vol.122 , pp. 573-579
    • Mellors, J.W.1    Kingsley, L.A.2    Rinaldo, C.R.3    Aj, E.4
  • 8
    • 0028914761 scopus 로고
    • Predictors for non-and slow progression in HIV-1 infection: Low viral RNA copy numbers in serum and maintenance of high HIV-1 p24-specific but not V3-specific antibody levels
    • Hogervorst E, Jurriaans S, de Wolf F, et al.: Predictors for non-and slow progression in HIV-1 infection: low viral RNA copy numbers in serum and maintenance of high HIV-1 p24-specific but not V3-specific antibody levels. I Infect Dis 1995, 171:811-821.
    • (1995) I Infect Dis , vol.171 , pp. 811-821
    • Hogervorst, E.1    Jurriaans, S.2    De Wolf, F.3
  • 9
    • 0028212705 scopus 로고
    • Quantification of HIV-1 virus load under zidovudine therapy in patients with symptomatic HIV infection: Relation to disease progression
    • Molina J-M, Perchai F, Chevret S, et al.: Quantification of HIV-1 virus load under zidovudine therapy in patients with symptomatic HIV infection: relation to disease progression. AIDS 1994, 8:27-33.
    • (1994) AIDS , vol.8 , pp. 27-33
    • Molina, J.-M.1    Perchai, F.2    Chevret, S.3
  • 10
    • 0028000730 scopus 로고
    • Evaluation of proviral copy number and plasma RNA level as early indicators of progression in HIV-1 infection: Correlation with virological and immunological markers of disease
    • Verhofstede C, Reniers S, Van Wanzeele F, Plum J: Evaluation of proviral copy number and plasma RNA level as early indicators of progression in HIV-1 infection: correlation with virological and immunological markers of disease. AIDS 1994, 8:1421-1427.
    • (1994) AIDS , vol.8 , pp. 1421-1427
    • Verhofstede, C.1    Reniers, S.2    Van Wanzeele, F.3    Plum, J.4
  • 11
    • 0029039865 scopus 로고
    • The prognostic value of plasma viraemia in HIV-infected patients under AZT treatment: A two-year follow-up study
    • Ruffault A, Michelet C, Jacquelinet C, et al.: The prognostic value of plasma viraemia in HIV-infected patients under AZT treatment: a two-year follow-up study. J Acquir Immune Defic Syndf 1995, 9:243-248.
    • (1995) J Acquir Immune Defic Syndf , vol.9 , pp. 243-248
    • Ruffault, A.1    Michelet, C.2    Jacquelinet, C.3
  • 12
    • 0030058515 scopus 로고    scopus 로고
    • The relationship of treatment-induced changes in plasma HIV-1 RNA and CD4+ lymphocyte count to progression to AIDS in the Department of Veterans Affairs Zidovudine Study
    • O'Brien WA, Hartigan PM, Martin D, et al.: The relationship of treatment-induced changes in plasma HIV-1 RNA and CD4+ lymphocyte count to progression to AIDS in The Department of Veterans Affairs Zidovudine Study. N Engl J Med 1996, 334:426-431.
    • (1996) N Engl J Med , vol.334 , pp. 426-431
    • O'Brien, W.A.1    Hartigan, P.M.2    Martin, D.3
  • 14
    • 0030022017 scopus 로고    scopus 로고
    • Longitudinal serum HIV RNA quantification: Correlation to viral phenotype at seroconversion and clinical outcome
    • Katzenstein TL, Pedersen C, Nielsen C, Lundgren JD, Jakobsen PH, Gerstoft J: Longitudinal serum HIV RNA quantification: correlation to viral phenotype at seroconversion and clinical outcome. AIDS 1996, 10:167-174.
    • (1996) AIDS , vol.10 , pp. 167-174
    • Katzenstein, T.L.1    Pedersen, C.2    Nielsen, C.3    Lundgren, J.D.4    Jakobsen, P.H.5    Gerstoft, J.6
  • 15
    • 0025130120 scopus 로고
    • Increasing viral burden in CD4+T cells from patients with HIV infection reflects rapidly progressive immunosuppression and clinical disease
    • Schnittman SM, Greenhouse JJ, Psallidopoulos MC, et al.: Increasing viral burden in CD4+T cells from patients with HIV infection reflects rapidly progressive immunosuppression and clinical disease. Ann Intern Med 1990, 113:438-443.
    • (1990) Ann Intern Med , vol.113 , pp. 438-443
    • Schnittman, S.M.1    Greenhouse, J.J.2    Psallidopoulos, M.C.3
  • 16
    • 0027525271 scopus 로고
    • High concentration of PBMCs harbouring infectious virus correlates with rapid progression of HIV-1 related diseases
    • Lu W, Grassi F, Tourani J-M, et al.: High concentration of PBMCs harbouring infectious virus correlates with rapid progression of HIV-1 related diseases. J Infect Dis 1993, 168:1165-1168.
    • (1993) J Infect Dis , vol.168 , pp. 1165-1168
    • Lu, W.1    Grassi, F.2    Tourani, J.-M.3
  • 17
    • 0028177883 scopus 로고
    • Circulating HIV-1 infected cell burden from seroconversion to AIDS: Importance of postseroconversion viral load on disease course
    • Lee T-H, Sheppard HW, Reis M, Dondero D, Osmond D, Busch MP: Circulating HIV-1 infected cell burden from seroconversion to AIDS: importance of postseroconversion viral load on disease course. J Acquir Immune Defic Syndr 1994, 7:3 81 -3 88.
    • (1994) J Acquir Immune Defic Syndr , vol.7 , pp. 381-388
    • Lee, T.-H.1    Sheppard, H.W.2    Reis, M.3    Dondero, D.4    Osmond, D.5    Busch, M.P.6
  • 18
    • 0027409934 scopus 로고
    • Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in HIV-1 infected individuals
    • Connor Rl, Mohri H, Cao Y, Ho DD: Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in HIV-1 infected individuals. / Virol 1993, 67:1772-1777.
    • (1993) / Virol , vol.67 , pp. 1772-1777
    • Rl, C.1    Mohri, H.2    Cao, Y.3    Ho, D.D.4
  • 19
    • 0026543981 scopus 로고
    • Viral DNA and mRNA expression correlate with the stage of HIV-1 infection in humans: Evidence for viral replication in all stages of HIV disease
    • Michael NL, Vahey M, Burke DS, Redfield RR: Viral DNA and mRNA expression correlate with the stage of HIV-1 infection in humans: evidence for viral replication in all stages of HIV disease. J Virol 1992, 66:310-316.
    • (1992) J Virol , vol.66 , pp. 310-316
    • Michael, N.L.1    Vahey, M.2    Burke, D.S.3    Redfield, R.R.4
  • 20
    • 0025876674 scopus 로고
    • Low HIV-1 proviral DNA burden detected'by negative polymerase chain reaction in seropositive individuals correlates with slower disease progression
    • Schlechter MT, Neumann PW, Weaver MS, ef ai: Low HIV-1 proviral DNA burden detected'by negative polymerase chain reaction in seropositive individuals correlates with slower disease progression. AIDS 1991, 5:373-379.
    • (1991) AIDS , vol.5 , pp. 373-379
    • Schlechter, M.T.1    Neumann, P.W.2    Weaver, M.S.3
  • 21
    • 0025762850 scopus 로고
    • Correlation between CD4 cell counts and cellular and plasma viral load in HIV-1 seropositive individuals
    • Venet A, Lu W, Beldjord K, Andrieu JM: Correlation between CD4 cell counts and cellular and plasma viral load in HIV-1 seropositive individuals. AIDS 1991, 5:283-288.
    • (1991) AIDS , vol.5 , pp. 283-288
    • Venet, A.1    Lu, W.2    Beldjord, K.3    Andrieu, J.M.4
  • 22
    • 0025134935 scopus 로고
    • Productive human immunodeficiency virus infection levels correlate with AIDSrelated manifestations in the patient
    • Mathez D, Paul D, de Belivovsky C, et al.: Productive human immunodeficiency virus infection levels correlate with AIDSrelated manifestations in the patient. Proc Natl Acad Sci USA 1990,87:7438-7442.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 7438-7442
    • Mathez, D.1    Paul, D.2    De Belivovsky, C.3
  • 23
    • 0025762354 scopus 로고
    • Detection and quantification of human immunodeficiency virus RNA in patient serum by use of the polymerase chain reaction
    • Holidniy M, Katzenstein DA, Sengupta S, et al.: Detection and quantification of human immunodeficiency virus RNA in patient serum by use of the polymerase chain reaction. J Infect Dis 1991, 163:862-866.
    • (1991) J Infect Dis , vol.163 , pp. 862-866
    • Holidniy, M.1    Katzenstein, D.A.2    Sengupta, S.3
  • 24
    • 0026767534 scopus 로고
    • Towards a new predictor of AIDS progression through the quantitation of HIV-1 DNA copies by PCR in HIV-infected individuals
    • Lefrere JJ, Mariotti M, Wattel E, et al.: Towards a new predictor of AIDS progression through the quantitation of HIV-1 DNA copies by PCR in HIV-infected individuals. Br J Haematol 1992, 82:467-471.
    • (1992) Br J Haematol , vol.82 , pp. 467-471
    • Lefrere, J.J.1    Mariotti, M.2    Wattel, E.3
  • 25
    • 0027503137 scopus 로고
    • Quantification and comparison of HIV-1 proviral load in peripheral blood mononuclear cells and isolated CD4+ T cells
    • Wood R, Dong H, Katzenstein DA, Merigan TC: Quantification and comparison of HIV-1 proviral load in peripheral blood mononuclear cells and isolated CD4+ T cells. J Acquir Immune Defic Syndr 1993, 6:237-240.
    • (1993) J Acquir Immune Defic Syndr , vol.6 , pp. 237-240
    • Wood, R.1    Dong, H.2    Katzenstein, D.A.3    Merigan, T.C.4
  • 26
    • 0026490851 scopus 로고
    • Molecular profile of human immunodeficiency virus type 1 infection in symptomless patients and in patients with AIDS
    • Bagnarelli P, Menzo S, Valenza A, et al.: Molecular profile of human immunodeficiency virus type 1 infection in symptomless patients and in patients with AIDS. J Virol 1992, 66:7328-7335.
    • (1992) J Virol , vol.66 , pp. 7328-7335
    • Bagnarelli, P.1    Menzo, S.2    Valenza, A.3
  • 27
    • 0026591030 scopus 로고
    • Quantitation of HIV viral burden by PCR in HIV seropositive Navy personnel representing Walter Reed stages 1 to 6
    • Ferre F, Marchese A, Duffy PC, et al.: Quantitation of HIV viral burden by PCR in HIV seropositive Navy personnel representing Walter Reed stages 1 to 6. AIDS Res Hum Retroviruses 1992, 8:269-275.
    • (1992) AIDS Res Hum Retroviruses , vol.8 , pp. 269-275
    • Ferre, F.1    Marchese, A.2    Duffy, P.C.3
  • 28
    • 0027430660 scopus 로고
    • Enhanced expression of human immunodeficiency virus type 1 correlates with the development of AIDS
    • Cupta P, Kingsley L, Armstrong J, Ding M, Cottrill M, Rinaldo C: Enhanced expression of human immunodeficiency virus type 1 correlates with the development of AIDS. Virology 1993, 196:586-595.
    • (1993) Virology , vol.196 , pp. 586-595
    • Cupta, P.1    Kingsley, L.2    Armstrong, J.3    Ding, M.4    Cottrill, M.5    Rinaldo, C.6
  • 29
    • 0028810243 scopus 로고
    • HIV-1 messenger RNA in peripheral blood mononuclear cells as an early marker of risk for progression to AIDS
    • Saksela K, Stevens CE, Rubenstein P, Taylor PE, Baltimore D: HIV-1 messenger RNA in peripheral blood mononuclear cells as an early marker of risk for progression to AIDS. Ann Intern Med 1995,123:641-648.
    • (1995) Ann Intern Med , vol.123 , pp. 641-648
    • Saksela, K.1    Stevens, C.E.2    Rubenstein, P.3    Taylor, P.E.4    Baltimore, D.5
  • 30
    • 0029035559 scopus 로고
    • Serum HIV-1 RNA and routine patient monitoring [letter]
    • Phillips AN, Sabin CA, Mocroft A: Serum HIV-1 RNA and routine patient monitoring [letter], lancet 1995, 345:1441.
    • (1995) Lancet , vol.345 , pp. 1441
    • Phillips, A.N.1    Sabin, C.A.2    Mocroft, A.3
  • 31
    • 0029563673 scopus 로고
    • Treatment with lamivudine, zidovudine, or both in HIV-positive patients with 200 to 500 CD4+ cells per cubic millimeter
    • Eron JJ, Benoit SL, Jemsek J, et al.: Treatment with lamivudine, zidovudine, or both in HIV-positive patients with 200 to 500 CD4+ cells per cubic millimeter. N Engl J Med 1995, 333:1662-1669.
    • (1995) N Engl J Med , vol.333 , pp. 1662-1669
    • Eron, J.J.1    Benoit, S.L.2    Jemsek, J.3
  • 33
    • 0027122957 scopus 로고
    • Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults
    • Centers for Disease Control: 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR 1992, 41 (RR-17):1-19.
    • (1992) MMWR , vol.41 , Issue.RR-17 , pp. 1-19
  • 34
    • 0027483004 scopus 로고
    • AIDS risk in recent and long-standing HIV-infected people with similar CD4 lymphocyte counts
    • Phillips AN, Sabin CA, Elford J, Bofill M, Janossy G, Lee CA: AIDS risk in recent and long-standing HIV-infected people with similar CD4 lymphocyte counts. Am J Epidemiol 1993,138:870-878.
    • (1993) Am J Epidemiol , vol.138 , pp. 870-878
    • Phillips, A.N.1    Sabin, C.A.2    Elford, J.3    Bofill, M.4    Janossy, G.5    Lee, C.A.6
  • 35
    • 0028095157 scopus 로고
    • CD4 lymphocyte count as a determinant of the time from HIV seroconversion to AIDS and death from AIDS: Evidence from the Italian Serocon-version Study
    • Phillips AN, Pezzotti P, Cozzi Lepri A, Rezza G: CD4 lymphocyte count as a determinant of the time from HIV seroconversion to AIDS and death from AIDS: evidence from the Italian Serocon-version Study. AIDS 1994, 8:1299-1305.
    • (1994) AIDS , vol.8 , pp. 1299-1305
    • Phillips, A.N.1    Pezzotti, P.2    Cozzi Lepri, A.3    Rezza, G.4
  • 36
    • 0029081229 scopus 로고
    • Lower prevalence and incidence of HIV-1 syncytium-inducing phenotype among injecting drug users compared with homosexual men
    • Spijkerman IJB, Koot M, Prins M, et al.: Lower prevalence and incidence of HIV-1 syncytium-inducing phenotype among injecting drug users compared with homosexual men. AIDS 1995,9:1085-1092.
    • (1995) AIDS , vol.9 , pp. 1085-1092
    • Ijb, S.1    Koot, M.2    Prins, M.3
  • 37
    • 0029863428 scopus 로고    scopus 로고
    • Lower prevalence and incidence of HIV-1 syncytium-inducing phenotype among injecting drug users relative to homosexual men
    • Mocroft A, Sabin CA, Phillips AN: Lower prevalence and incidence of HIV-1 syncytium-inducing phenotype among injecting drug users relative to homosexual men. AIDS 1996,10:344-345.
    • (1996) AIDS , vol.10 , pp. 344-345
    • Mocroft, A.1    Sabin, C.A.2    Phillips, A.N.3
  • 38
    • 0026465178 scopus 로고
    • Studies of prognostic markers in HIV infection: Implications for pathogenesis
    • Phillips AN: Studies of prognostic markers in HIV infection: implications for pathogenesis. AIDS 1992, 6:1391-1394.
    • (1992) AIDS , vol.6 , pp. 1391-1394
    • Phillips, A.N.1
  • 39
    • 0028087289 scopus 로고
    • Practical problems in fitting a pro-portional hazards model to data with updated measurements of the covariates
    • Altman DG, De Stavola BL: Practical problems in fitting a pro-portional hazards model to data with updated measurements of the covariates. Stat Med 1994,13:301-341.
    • (1994) Stat Med , vol.13 , pp. 301-341
    • Altman, D.G.1    De Stavola, B.L.2
  • 40
    • 0028177872 scopus 로고
    • Diurnal and short-term stability of viral load as measured by gene amplification
    • Holodniy M, Mole L, Winters M, Merigan TC: Diurnal and short-term stability of viral load as measured by gene amplification. J Acquir Immune Defic Syndr 1994, 7:363-368.
    • (1994) J Acquir Immune Defic Syndr , vol.7 , pp. 363-368
    • Holodniy, M.1    Mole, L.2    Winters, M.3    Merigan, T.C.4
  • 41
    • 0026771090 scopus 로고
    • HIV-1 viraemia and influenza [letter]
    • Ho DD: HIV-1 viraemia and influenza [letter]. Lancet 1992, 339:1549.
    • (1992) Lancet , vol.339 , pp. 1549
    • Ho, D.D.1
  • 42
    • 0028086535 scopus 로고
    • Influenza immunization of HIV-1 infected patients does not increase HIV-1 viral load [letter]
    • Yerly S, Wunderli W, Wyler ÇA, et al.: Influenza immunization of HIV-1 infected patients does not increase HIV-1 viral load [letter]. AIDS 1994, 8:1503-1504.
    • (1994) AIDS , vol.8 , pp. 1503-1504
    • Yerly, S.1    Wunderli, W.2    Wyler, Ç.A.3
  • 43
    • 0028811974 scopus 로고
    • Viral dynamics in HIV-1 infection
    • Wei X, Ghosh SK, Taylor ME, et al.: Viral dynamics in HIV-1 infection. Nature 1995, 373:117-126.
    • (1995) Nature , vol.373 , pp. 117-126
    • Wei, X.1    Ghosh, S.K.2    Taylor, M.E.3
  • 44
    • 0028874048 scopus 로고
    • Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
    • Ho DD, et al.: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995, 373:123-126.
    • (1995) Nature , vol.373 , pp. 123-126
    • Ho, D.D.1
  • 45
    • 0025924025 scopus 로고
    • How independent are 'independent' effects? Relative risk estimation when correlated exposures are measured imprecisely
    • Phillips AN, Davey Smith G: How independent are 'independent' effects? Relative risk estimation when correlated exposures are measured imprecisely. J Clin Epidemiol 1991, 44:1223-1231.
    • (1991) J Clin Epidemiol , vol.44 , pp. 1223-1231
    • Phillips, A.N.1    Davey Smith, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.