Apolipoprotein-E deficiency results in an altered stress responsiveness in addition to an impaired spatial memory in young mice

Brain Research

Volumn 788, Issue 1-2, 1998, Pages 151-159

  Zhou, You ^a   Elkins, P David ^a   Howell, Leigh A ^a   Ryan, Donna H ^a   Harris, Ruth B S ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

ApoE deficient mice; Corticosterone; mRNA expression; Restraint stress; Spatial memory

Indexed keywords

APOLIPOPROTEIN E; CORTICOSTERONE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; GENE EXPRESSION; HORMONE RESPONSE; HYPERLIPOPROTEINEMIA TYPE 3; HYPOTHALAMUS; IMMOBILIZATION STRESS; LEARNING TEST; MALE; MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPATIAL MEMORY;

ANALYSIS OF VARIANCE; ANIMALS; APOLIPOPROTEINS E; CORTICOSTERONE; GENOTYPE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; RESTRAINT, PHYSICAL; STRESS;

EID: 0032579792     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01533-3     Document Type: Article

References (40)

1. Aamar S., Saada A., Rotshenker S. Lesion-induced changes in the production of newly synthesized and secreted ApoE and other molecules are independent of the concomitant recruitment of blood-borne macrophages into injured peripheral nerves. J. Neurochem. 59:1992;1287-1292.
2. D. Armanini, F. Vecchio, A. Basso, C. Gottardo, S. Zovato, M. Simoncini, A. Spigariol, I. Karbowiak, F.F. Milone, Alzheimer's disease: implications of measurement of plasma cortisol, dehydroepiandrosterone sulphate, and corticosteroid receptors in mononuclear leukocytes, The Endocrine Society, 79th Annual Meeting, 1997, p. 237.
3. Breslow J.L. Apolipoprotein genetic variation and human disease. Physiol. Rev. 68:1988;85-132.
4. Conrad C.D., Galea L.A., Kuroda Y., McEwen B.S. Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment. Behav. Neurosci. 110:1996;1321-1334.
5. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., Roses A.D., Haines J.L., Pericak-Vance M.A. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 261:1993;921-923. see comments.
6. Dallman M.F., Akana S.F., Strack A.M., Hanson E.S., Sebastian R.J. The neural network that regulates energy balance is responsive to glucocorticoids and insulin and also regulates HPA axis responsivity at a site proximal to CRF neurons. Ann. NY Acad. Sci. 771:1995;730-742.
7. Davis B.M., Mohs R.C., Greenwald B.S., Mathe A.A., Johns C.A., Horvath T.B., Davis K.L. Clinical studies of the cholinergic deficit in Alzheimer's disease: I. Neurochemical and neuroendocrine studies. J. Am. Geriatr. Soc. 33:1985;741-748.
8. De Leon M.J., George A.E., Golomb J., Tarshish C., Convit A., Klunger A., De Santi S., Mc Rae T., Ferris H., Reisberg B., Ince C., Rusinek H., Bobinski M., Quinn B., Miller D.C., Wisniewski H.M. Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease. Neurobiol. Aging. 18:1997;1-11.
9. Elshourbagy N.A., Liao W.S., Mahley R.W., Taylor J.M. Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets. Proc. Natl. Acad. Sci. U.S.A. 82:1985;203-207.
10. Francis D.D., Zaharia M.D., Shanks N., Anisman H. Stress-induced disturbances in Morris Water Maze performance: interstrain variability. Physiol. Behav. 58:1995;57-65.
11. Gandy S., Stafstrom C., Turner B., Sweeney D., Breslow J., Greengard P., Smith J., Ouimet C. Aged apoE-deficient mice: abnormal learning and glia markers but no obvious neuropathology. Soc. Neurosci. Abstr. 21:1995;5.
12. Gordon I., Ben-Eliyahu S., Rosenne E., Sehayek E., Michaelson D.M. Derangement in stress response of apolipoprotein E-deficient mice. Neurosci. Lett. 206:1996;212-214.
13. Gordon I., Grauer E., Genis I., Sehayek E., Michaelson D.M. Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice. Neurosci. Lett. 199:1995;1-4.
14. Haleem D.J., Zafar A., Azam S., Yasmeen A. Tolerance to diacetyl morphine antinociception: effects on brain serotonin. NeuroReport. 5:1994;781-784.
15. Higgins G.A., Large C.H., Rupniak H.T., Barnes J.C. Apolipoprotein E and Alzheimer's disease: a review of recent studies. Pharmacol. Biochem. Behav. 56:1997;675-685.
16. Holtzman D.M., Pitas R.E., Kilbridge J., Nathan B., Mahley R.W., Bu G., Schwartz A.L. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc. Natl. Acad. Sci. U.S.A. 92:1995;9480-9484.
17. Huang D.Y., Goedert M., Jakes R., Weisgraber K.H., Garner C.C., Saunders A.M., Pericak-Vance M.A., Schmechel D.E., Roses A.D., Strittmatter W.J. Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. Neurosci. Lett. 182:1994;55-58.
18. Mahley R.W., Nathan B.P., Pitas R.E. Apolipoprotein E: Structure, function, and possible roles in Alzheimer's disease. Ann. NY Acad. Sci. 777:1996;139-145.
19. Makino S., Smith M.A., Gold P.W. Increased expression of corticotrophin-releasing hormone and vasopressin messenger ribonucleic acid (mRNA) in the hypothalamic paraventricular nucleus during repeated stress: association with reduction in glucocorticoid receptor mRNA levels. Endocrinology. 136:1995;3299-3309.
20. Masliah E., Mallory M., Ge N., Alford M., Veinbergs I., Roses A.D. Neurodegeneration in the central nervous system of apoE-deficient mice. Exp. Neurol. 136:1995;107-122.
21. Masliah E., Samuel W., Veinbergs I., Mallory M., Mante M., Saitoh T. Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE. Brain Res. 751:1997;307-314.
22. Mouchel Y., Lefrancois T., Fages C., Tardy M. Apolipoprotein E gene expression in astrocytes: developmental pattern and regulation. NeuroReport. 7:1995;205-208.
23. Nathan B.P., Bellosta S., Sanan D.A., Weisgraber K.H., Mahley R.W., Pitas R.E. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science. 264:1994;850-852.
24. Nathan B.P., Chang K.C., Bellosta S., Brisch E., Ge N., Mahley R.W., Pitas R.E. The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization. J. Biol. Chem. 270:1995;19791-19799.
25. Ohm T. Does Alzheimer's disease start early in life? Mol. Psychiatry. 2:1997;21-25.
26. Pitas R.E., Boyles J.K., Lee S.H., Foss D., Mahley R.W. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim. Biophys. Acta. 917:1987;148-161.
27. Plump A.S., Breslow J.L. Apolipoprotein E and the apolipoprotein E-deficient mouse. Annu. Rev. Nutr. 15:1995;495-518.
28. Poirier J., Hess M., May P.C., Finch C.E. Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning. Brain Res. Mol. Brain Res. 11:1991;97-106.
29. Rajavashisth T.B., Kaptein J.S., Reue K.L., Lusis A.J. Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit. Proc. Natl. Acad. Sci. U.S.A. 82:1985;8085-8089.
30. Roses A.D., Einstein G., Gilbert J., Goedert M., Han S.H., Huang D., Hulette C., Masliah E., Pericak-Vance M.A., Saunders A.M., Schmechel D.E., Strittmatter W.J., Weisgraber K.H., Xi P.T. Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. Ann. NY Acad. Sci. 777:1996;146-157.
31. Rybkin I.R., Zhou Y., Volaufova J., Smagin G.N., Ryan D.H., Harris R.B.S. The effect of restraint stress on food intake and body weight is determined by time of day. Am. J. Physiol. 273:1997;R1612-R1622.
32. Sapolsky R.M. Why stress is bad for your brain. Science. 273:1996;749-750.
33. Sapolsky R.M., Krey L.C., McEwen B.S. Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging. J. Neurosci. 5:1985;1222-1227.
34. Shors T.J., Thompson R.F. Acute stress impairs (or induces) synaptic long-term potentiation (LTP) but does not affect paired-pulse facilitation in the stratum radiatum of rat hippocampus. Synapse. 11:1992;262-265.
35. Stokes P.E. The potential role of excessive cortisol induced by HPA hyperfunction in the pathogenesis of depression. Eur. Neuropsychopharmacol. 5:1995;77-82.
36. Stratakis C.A., Chrousos G.P. Neuroendocrinology and pathophysiology of the stress system. Ann. NY Acad. Sci. 771:1995;1-18.
37. Strittmatter W.J., Saunders A.M., Goedert M., Weisgraber K.H., Dong L.M., Jakes R., Huang D.Y., Pericak-Vance M., Schmechel D., Roses A.D. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 91:1994;11183-11186.
38. Strittmatter W.J., Weisgraber K.H., Goedert M., Saunders A.M., Huang D., Corder E.H., Dong L.M., Jakes R., Alberts M.J., Gilbert J.R.et al. Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp. Neurol. 125:1994;163-171. discussion 172-174.
39. Strittmatter W.J., Weisgraber K.H., Huang D.Y., Dong L.M., Salvesen G.S., Pericak-Vance M., Schmechel D., Saunders A.M., Goldgaber D., Roses A.D. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 90:1993;8098-8102.
40. Whishaw I.Q. Formation of a place learning-set by the rat: a new paradigm for neurobehavioral studies. Physiol. Behav. 35:1985;139-143.