A self-sensitized photoreaction of rhodacyanine dye, MKT 077

Tetrahedron Letters

Volumn 39, Issue 13, 1998, Pages 1763-1766

  Kawakami, Masayuki ^a   Suzuki, Makoto ^a   Kawai, Hideyoshi ^a   Ogawa, Keizo ^a   Shishido, Tadao ^a  

^a FUJIFILM CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CATIONIC RHODACYANINE; CYANINE DYE; UNCLASSIFIED DRUG;

ARTICLE; DRUG OXIDATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHOTODEGRADATION; PHOTOREACTIVITY; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0032568349     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00038-0     Document Type: Article

References (12)

1. 1 a) Koya, K.; Wang, Y. L. H.; Ukai, T.; Tatsuta, N.; Kawakami, M.; Shishido, T.; Chen, L. B. Cancer Res. 1996, 56, 538-543.
2. b) Kawakami, M.; Koya, K.; Ukai, T.; Tatsuta, N.; Ikegawa, A.; Ogawa, K.; Shishido, T.; Chen, L. B. J. Med. Chem. in press.
3. 2 a) Modica-Napolitano, J. S.; Koya, K.; Weisberg, E.; Brunelli, B. T.; Li, Y.; Chen, L. B. Cancer Res. 1996, 56, 544-550.
4. b) Weisberg, E.; Koya, K.; Modica-Napolitano, J.; Li, Y.; Chen, L. B. Cancer Res. 1996, 56, 551-555.
5. 3 HPLC condition: column; Tosoh Tsk-Gel ODS-80 Tm (4.7 × 150 mm), eluent; methanol/water = 2/3 containing 0.2 % acetic acid/triethylamine (flow rate; 1.0 mL/min).
6. 4 Solar, P.; Denny G. H., Jr.; Babson, R. D. Heterocycl. Chem. 1969, 6, 163-174.
7. 5 Compound 3 was synthesized by alkaline hydrolysis of 3-Ethyl-5-(3-methylbenzothiaolin-2-yliden)-2-methylthio-4-oxothiazolinium p-toluenesulfonate, which was the intermediate of MKT 077 (1) (see reference 1.b).
8. 6. The mass number and the absorption spectrum of peak C were obtained by using LC-MC (Thermoquest Co., TSQ7000) and a multichannel HPLC (Shimadzu Co., SPD-10AV), respectively.
9. 7 a) Sakamoto, M.; Takahashi, M.; Moriizumi, S.; Yamaguchi, K.; Fujita, T.; Watanabe, S. J. Am. Chem. Soc. 1996,118, 8138-8139.
10. b) Penn, J. H.; Liu, F. J. Org. Chem. 1994, 59, 2608-2612.
11. 2S calcd, 262.0776; found 262.0771.
12. 3 calcd, 246.1004; found 246.1013.