Human cytomegalovirus infection downregulates expression of the cellular aminopeptidases CD10 and CD13

Virology

Volumn 250, Issue 2, 1998, Pages 350-358

  Phillips, A J ^a   Tomasec, P ^a   Wang, E C Y ^b   Wilkinson, G W G ^a   Borysiewicz, L K ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; METHIONINE; MICROSOMAL AMINOPEPTIDASE; POLYADENYLATED RNA; SULFUR 35; VIRUS DNA;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DNA REPLICATION; DOWN REGULATION; ENZYME ASSAY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; VIRUS INFECTION;

CYTOMEGALOVIRUS; DNA VIRUSES; HUMAN HERPESVIRUS 5;

EID: 0032566922     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1998.9385     Document Type: Article

References (59)

1. Ahn K., Angulo A., Ghazal P., Peterson P., Yang Y., Früh K. Human cytomegalovirus inhibits antigen presentation by a sequential multistep process. Proc. Natl. Acad. Sci. USA. 93:1996;10990-10995.
2. Ahn K., Gruhler A., Galocha B., Jones T. R., Wiertz E. J., Ploegh H. L., Peterson P. A., Yang Y., Früh K. The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. Immunity. 6:1997;613-621.
3. Boppana S. B., Pass R. F., Britt W. J., Stagno S., Alford C. A. Symptomatic congenital cytomegalovirus infection: Neonatal morbidity and mortality. Pediatr. Infect. Dis. 11:1992;93-99.
4. Borysiewicz L. K., Graham S., Sissons J. G. Human natural killer cell lysis of virus-infected cells. Relationship to expression of the tranferrin receptor. Eur. J. Immunol. 16:1986;405-411.
5. Caswell R., Bryant L., Sinclair J. Human cytomegalovirus immediate early 2 (IE2) protein can transactivate the human hsp70 promoter by alleviation of Dr1-mediated repression. J. Virol. 70:1996;4028-4037.
6. Davignon J.-L., Cataine P., Yorke J. A., Gautier N., Clement D., Davrinch C. Anti-human cytomegalovirus activity of human cytokines produced by CD4+ T cell clones specifically activated by IE1 peptides in vitro. J. Virol. 70:1996;2162-2169.
7. Delmas B., Gelfi J., Haridon R., Vogel L. K., Sjöström H., Norén O., Laude H. Aminopeptidase N is a major receptor for the enteropathogenic cornavirus TGEV. Nature. 357:1992;417-420.
8. Del Val M., Hengel H., Häcker H., Hartlaub U., Ruppert T., Lucin P., Koszinowski U. H. CMV prevents antigen presentation by blocking the transport of peptide loaded MHC class I into the medial Golgi. J Exp. Med. 176:1992;729-738.
9. Devault A, Nault C., Zollinger M., Fournie-Zaluski M.-C., Roques B. P., Crine P., Boileus G. Expression of neutral endopeptidase (enkephalinase) in heterogenous COS-1 cells. Characterization of the recombinant enzyme and evidence for a glutamic acid residue at the active site. J. Biol. Chem. 263:1988;4033-4040.
10. Elliot T., Willis A., Cerundolo V., Townsend A. Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum. J. Exp. Med. 181:1995;1481-1491.
11. Falk K., Rötzchke O., Deres K., Metzger J., Jung G., Rammensee H. G. Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast. J. Exp. Med. 174:1991;425-434.
12. Falk K., Rötzschke O. Consensus motifs and peptide ligands of MHC class I molecules. Semin. Immuno. 5:1993;81-94.
13. Gautier N., Chavant E., Prieur E., Monsarrat T., Mazarguil H., Davrinch C., Gairin J. E., Davignon J.-L. Characterization of an epitope of the human cytomegalovirus protein IE1 recognized by a CD4+ T cell clone. Eur. J. Immunol. 26:1996;1110-1117.
14. Gilbert M. J., Riddell S. R., Plachter B., Greenberg P. D. Cytomegalovirus selectively blocks antigen processing and presentation of its immediate-early gene product. Nature. 383:1996;720-722.
15. Graf K., Gräfe M., Bossaller C., Niehus J., Schulz K. D., Auch-Schwelk W., Fleck E. Degradation of bradykinin by neutral endopeptidase (EC 3.4.24.11) in cultured human endothelial cells. Eur. J Chem. Clin. Biochem. 31:1993;267-272.
16. Graham F. L., Smiley J., Russell W. C., Nairn R. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36:1977;59-74.
17. Griffin J. D., Ritz J., Nadler L. M., Sclossman S. F. Expression of myeloid differentiation antigens on normal and malignant myeloid cells. J. Clin. Invest. 68:1981;932-941.
18. Hagemeier C., Walker S. M., Sissons P. J. G., Sinclair J. H. The 72K IE1 and 80K IE2 proteins of human cytomegalovirus independently transactivate the c-fos, c-myc and hsp70 promoters via basal promoter elements. J. Gen. Virol. 73:1992;2385-2393.
19. Hansen A. S., Norén O., Sjöström H., Werdelin O. A mouse aminopeptidase N is a marker for antigen presenting cells and appears to be co-expressed with MHC class I molecules. Eur. J. Immunol. 23:1993;2358-2364.
20. Hengel H., Flohr T., Hammerling G. J., Koszinowski U. H. Human cytomegalovirus inhibits peptide translocation into the endoplasmic reticulum for MHC class I assembly. J. Gen. Virol. 77:1996;2287-2296.
21. Hogg N., Horton M. A. Myeloid antigens: New and previously defined clusters. Leukocyte Typing III, Proceedings of the Third International Workshop on Human Leukocyte Differentiation Antigens. 1987.
22. Jones T. R., Hanson L. K., Sun L., Slater J. S., Stenberg R. M., Campbell A. E. Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains. J. Virol. 69:1995;4830-4841.
23. Koopman J.-O., Post M., Neefjes J. J., Hämmerling G., Momburg F. Translocation of long peptides by transporters associated with antigen processing (TAP). Eur. J. Immunol. 26:1996;1720-1728.
24. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
25. Larsen S. L., Pedersen L. O., Buus S., Stryhn A. T cell responses affected by aminopeptidase N (CD13)-mediated trimming of major histocompatibility complex class II-bound peptides. J. Exp. Med. 184:1996;183-189.
26. Lehner P. J., Karttunen J. T., Wilkinson G. W. G., Cresswell P. The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation. Proc. Natl. Acad. Sci. USA. 94:1997;6904-6909.
27. Lendeckel U., Wex Th., Kahne Th., Frank K., Reinhold D., Ansorge S. Expression of the Aminopeptidase N (CD13) gene in the human T cell lines HuT78 and H9. Cell. Immunol. 153:1994;214-226.
28. Letarte M., Vera S., Tran R., Addis J. B. L., Onizuka R. J., Quackenbush E. J., Jongeneel C. V., McInnes R. R. Common acute lymphoblastic leukemia antigen is identical to neutral endopeptidase. J. Exp. Med. 168:1988;1247-1253.
29. Look A. T., Ashmun R. A., Shapiro L. H., Peiper S. C. Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to APN. J. Clin. Invest. 83:1989;1299-1307.
30. Machold R. P., Wiertz E. J. H., Jones T. R., Ploegh H. L. The HCMV gene products US11 and US2 differ in their ability to attack allelic forms of murine major histocompatibility complex (MHC) class I heavy chains. J. Exp. Med. 185:1997;363-366.
31. Mendelson M., Monard S., Sissons P., Sinclair J. Detection of endogenous human cytomegalovirus in CD34+ bone marrow progenitors. J. Gen. Virol. 77:1996;3099-3102.
32. Mouritsen S., Meldal M., Werdelin O., Hansen A. S., Buus S. MHC molecules protect T cell epitopes against proteolytic destruction. J. Immunol. 149:1992;1987-1993.
33. Pande H., Terramani T., Tressel T., Churchill M. A., Hawkins G. G., Zaia J. A. Altered expression of fibronectin in cells infected with human cytomegalovirus. J. Virol. 64:1990;1366-1369.
34. Piela-Smith T. H., Korn J. H. Aminopeptidase N: A constitutive cell-surface protein on human dermal fibroblasts. Cell. Immunol. 162:1995;42-48.
35. Plakidou-Dymock S., Tanner M. J., McGivan J. D. A role for aminopeptidase N in Na+-dependent amino acid transport in bovine renal brush-border membranes. Biochem. J. 290:1993;59-65.
36. Riemann, D. Kehlen, A. Thiele, M. Löhn, M. Langner, J. 1997, Co-incubation of lymphocytes with fibroblast-like synoviocytes and other cell types can induce lymphocytic surface expression of Aminopeptidase N/CD13, In, Cellular Peptidases in Immune Functions and Disease, AnsorgeLangner, Plenum Press, NY.
37. Roelse J., Grommé M., Momburg F., Hämmerling G., Neefjes J. Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling. J. Exp. Med. 180:1994;1591-1597.
38. Sadasivan B., Lehner P. J., Ortmann B., Spies T., Cresswell P. Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP. Immunity. 5:1996;103-114.
39. Schneider-Schaulies J., Dunster L. M., Kobune F., Rima B., ter Meulen V. Differential downregulation of CD46 by measles virus strains. J. Virol. 69:1995;7257-7259.
40. Schumacher T. N., Kantesaria D. V., Heemels M. T., Ashton-Rickardt P. G., Shepherd J. C., Früh K., Yang Y., Peterson P. A., Tonegawa S., Ploegh H. L. Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator. J. Exp. Med. 179:1994;533-540.
41. Schwartz R., Helmich B., Spector D. H. CREB and CREB-binding proteins play an important role in the IE2 86-kDa protein-mediated transactivation of the human cytomegalovirus 2.2- kilobase RNA promoter. J. Virol. 70:1996;6955-6966.
42. Sedmak D. D., Guglielmo M., Knight D., Birmingham D. J., Huang E. H., Waldman W. J. Cytomegalovirus inhibits major histocompatibility complex class II expression on infected endothelial cells. Am. J. Pathol. 144:1994;683-392.
43. Semenza G. Anchoring and biosynthesis of stalked brush border membrane proteins. Annu. Rev. Cell Biol. 2:1986;255-313.
44. Snyder H. L., Yewdell J. W., Bennink J. R. Trimming of antigenic peptides in an early secretory compartment. J. Exp. Med. 180:1994;2389-2394.
45. Söderberg C., Giugni T. D., Zaia J. A., Larsson S., Wahlberg J. M., Möller E. CD13 (aminopeptidase N) mediates HCMV infection. J. Virol. 67:1993a;6576-6585.
46. Söderberg C., Larsson S., Bergstedt-Lindqvist S., Moller E. Identification of blood mononuclear cells permissive of cytomegalovirus infection in vitro. Transplant. Proc. 25:1993b;1416-1418.
47. Söderberg-Naucler C., Fish K. N., Nelson J. A. Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors. Cell. 91:1997a;119-126.
48. Söderberg-Naucler C., Fish K. N., Nelson J. Mechanisms of cytomegalovirus disease. Herpes. 4:1997b;4-9.
49. Stevenson M., Zhang X. H., Volsky D. J. Downregulation of cell surface molecules during noncytopathic infection of T cells with human immunodeficiency virus. J. Virol. 61:1987;3741-3748.
50. Taylor H. P., Cooper N. R. The human cytomegalovirus receptor on fibroblasts is a 30-kilodalton membrane protein. J. Virol. 64:1990;2484-2490.
51. Townsend A., Elliot T., Cerundolo V., Foster L., Barber B., Tse A. Assembly of MHC class I molecules analyzed in vitro. Cell. 62:1990;285-295.
52. Turner A. J., Hooper N. M., Kenny A. J. Metabolism of neuropeptides. Mammalian Ectoenzymes. 1987;Elsevier Science PublishersBiomedical Division, Amsterdam.
53. Warren A. P., Ducroq D. H., Lehner P. J., Borysiewicz L. K. HCMV-infected cells have unstable assembly of MHC class I and are resistant to lysis by CTL. J. Virol. 68:1994a;2822-2829.
54. Warren A. P., Owens C. N., Borysiewicz L. K., Patel K. Downregulation of integrin alpha1/beta1 expression and association with cell rounding in human cytomegalovirus-infected fibroblasts. J. Gen. Virol. 75:1994b;3319-3325.
55. Wiertz E. J. H., Jones T. R., Sun L., Bogyo M., Geuze H. J., Ploegh H. L. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell. 84:1996;769-779.
56. Yamshita Y., Shimokata K., Mizuno S., Yamaguchi H., Nishiyama Y. Downregulation of the surface expression of class I MHC antigens by HCMV. Virology. 193:1993;727-736.
57. Yamashita Y., Shikomata K., Saga S., Mizuno S., Tsurumi T., Nishiyama Y. Rapid degradation of the H chains of class I MHC antigens in the ER of HCMV-infected cells. J. Virol. 68:1994;7933-7943.
58. Yeager C. L., Ashmun R. A., Williams R. K., Cardellichio C. B., Shapiro L. H., Look A. T., Holmes K. V. Human aminopeptidase N is a receptor for human coronavirus 229E. Nature. 357:1992;420-422.
59. Yurochko A. D., Kowlaik T. F., Huong S.-M., Huang E.-S. Human cytomegalovirus upregulates NF-kappaB activity by transactivating the NF-kappaB p105/p50 and p65 promoter. J. Virol. 69:1995;5391-5400.