Alterations in local cerebral glucose utilization produced by D3 dopamine receptor-selective doses of 7-OH-DPAT and nafadotride

Brain Research

Volumn 812, Issue 1-2, 1998, Pages 193-199

  Levant, Beth ^a   Cross, Robert S ^a   Pazdernik, Thomas L ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

7 OH DPAT; 14C 2 deoxyglucose; Brain; D3 dopamine receptor; Local cerebral glucose utilization; Nafadotride; Rat

Indexed keywords

2 DIPROPYLAMINO 7 HYDROXYTETRALIN; DOPAMINE 3 RECEPTOR; NAFADOTRIDE; NEUROLEPTIC AGENT;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; NERVE CONDUCTION; NEUROTRANSMISSION; NONHUMAN; PREOPTIC AREA; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RAT; RECEPTOR OCCUPANCY; SUBSTANTIA NIGRA;

ANIMALS; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; MALE; NAPHTHALENES; NEURONS; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; TETRAHYDRONAPHTHALENES;

EID: 0032561734     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00924-X     Document Type: Article

References (30)

1. 3 receptor-selective ligand, 7-OH-DPAT, in the normal and the reserpine-treated rat. Eur. J. Pharmacol. 260:1994;177-181.
2. 3 dopamine receptor, in rat brain: a receptor binding and quantitative autoradiographic study Neuropsychopharmacology. 18:1998;305-316.
3. 2 receptor mRNA. Brain Res. 564:1991;203-219.
4. 3 dopamine receptors. Science. 260:1993;1814-1816.
5. Colangelo V., Di Grezia R., Passarelli F., Musicco M., Pontieri F.E., Orzi F. Differential effects of acute administration of clozapine or haloperidol on local cerebral glucose utilization in the rat. Brain Res. 768:1997;273-278.
6. 2-like' agonists. Neuropharmacology. 32:1993;509-510.
7. 3 receptor in the rat brain. Neuroscience. 65:1995;731-745.
8. R.L. Isaacson, The Limbic System, Plenum Press, New York, 1982.
9. 3-preferring agonist 7-OH-DPAT on motor behaviors and place conditioning. Psychopharmacology. 122:1995;351-357.
10. 3 receptor agonists, 7-OH-DPAT, and quinpirole, on yawning, stereotypy, and body temperature in rats. Pharmacol. Biochem. Behav. 52:1995;503-508.
11. 3 dopamine receptor: neurobiology and potential clinical relevance. Pharmacol. Rev. 49:1997;231-252.
12. 2 dopamine receptors by 7-OH-DPAT. Synapse. 24:1996;60-64.
13. 3 receptor: relevance for the drug treatment of Parkinson's disease, CNS Drugs (1998) in press.
14. 2 dopamine receptors by nafadotride. Neuropsychopharmacology. 17:1997;67-71.
15. McCulloch J., Savaski H.E., Sokoloff L. Distribution of the effects of haloperidol on energy metabolism in the rat brain. Brain Res. 243:1982;81-90.
16. Orzi F., Morelli M., Fieschi C., Pontieri F.E. Metabolic mapping of the pharmacological and toxicological effects of dopaminergic drugs in experimental animals. Cerebrovasc. Brain Metab. Rev. 5:1993;95-121.
17. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, 2nd edn., Academic Press, Sydney, 1986.
18. Pazdernik T.L., Cross R.S., Giesler M.P., Samson F.E., Nelson S.R. Changes in local cerebral glucose utilization induced by convulsants. Neuroscience. 14:1985;823-835.
19. 2 antagonist sulpiride on glucose utilization in dopaminergic regions of rat brain. J. Neurochem. 49:1987;631-638.
20. Pizzolato G., Soncrant T.T., Rapoport S.I. Haloperidol and cerebral metabolism in the conscious rat: relation to pharmacokinetics. J. Neurochem. 43:1984;724-732.
21. 3 receptor antagonist, activates locomotion in rodents. J. Pharmacol. Exp. Ther. 275:1995;1239-1246.
22. Seeman P., Van Tol H.H. Dopamine receptor pharmacology. Trends Pharmacol. Sci. 15:1994;264-270.
23. 14C) deoxyglucose method for the measurement of the local cerebral glucose utilization: theory, procedure and normal values in the conscious and anesthetized rat J. Neurochem. 28:1977;897-916.
24. 3) as a target for neuroleptics. Nature. 347:1990;146-151.
25. Stevens J.R. An anatomy of schizophrenia? Arch. Gen. Psychiatry. 29:1973;177-189.
26. 3 ligand R-(+)-7-OH-DPAT is independent of changes in dopamine release. J. Neural Transm. Gen. Sect. 95:1994;71-74.
27. Tarazi F.I., Shirakawa O., Tamminga C.A. Low dose raclopride spares the extrapyramidal system in rat brain for metabolic effects. Eur. J. Pharmacol. 232:1993;71-77.
28. 1 dopamine agonist and antagonist effects on regional cerebral glucose utilization in rats with intact dopaminergic innervation. Brain Res. 607:1993;270-274.
29. 2 dopamine agonists differentially alter basal ganglia glucose utilization in rats with unilateral 6-hydroxydopamine substantia nigra lesions. J. Neurosci. 7:1987;2927-2935.
30. 4 receptor mRNA levels in rat brain and pituitary during aging. Neurobiol. Aging. 15:1994;713-719.