In vivo occupancy of D2 dopamine receptors by 7-OH-DPAT

Synapse

Volumn 24, Issue 1, 1996, Pages 60-64

  Levant, Beth ^a   Bancroft, Gregory N ^a   Selkirk, Christina M ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

3H spiperone; EEDQ (N ethoxycarbonyl 2 ethoxy 1,2 dihydroquinoline); Rat; Striatum

Indexed keywords

2 ETHOXY 1(2H) QUINOLINECARBOXYLIC ACID ETHYL ESTER; DOPAMINE 2 RECEPTOR; MEMBRANE RECEPTOR; NEUROLEPTIC AGENT; SPIPERONE; 7 HYDROXY 2 N,N DIPROPYLAMINOTETRALIN; 7-HYDROXY-2-N,N-DIPROPYLAMINOTETRALIN; DOPAMINE RECEPTOR STIMULATING AGENT; TETRALIN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DATA ANALYSIS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR OCCUPANCY; ANIMAL; BINDING COMPETITION; DOSE RESPONSE; DRUG EFFECT; MALE; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; BINDING, COMPETITIVE; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; TETRAHYDRONAPHTHALENES;

EID: 0029657932     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199609)24:1<60::AID-SYN7>3.0.CO;2-E     Document Type: Article

References (26)

1. 3 receptor-selective ligand, 7-OH-DPAT, in the normal and the reserpine-treated rat. Eur. J. Pharmacol., 260: 177-181.
2. 2 receptor mRNA. Brain Res., 564:302-319.
3. Caine, S.B., and Koob, G.F. (1993) Modulation of cocaine self-administration in the rat through D-3 dopamine receptors. Science, 260:1814-1816.
4. Daly, S.A., and Waddington, J.L. (1993) Behavioral effects of the putative D-3 dopamine receptor agonist 7-OH-DPAT in relation to other "D-2-like" agonists. Neuropharmacology, 32:509-510.
5. Devoto, P., Collu, M., Muntoni, A.L., Pistis, M., Serra, G.L., Gessa, G., and Diana, M. (1995) Biochemical and electrophysiological effects of 7-OH-DPAT on the mesolimbic dopamine system. Synapse, 20:153-155.
6. 3 receptor and 7-OH-DPAT. Trends Pharmacol. Sci., 15:1.
7. 3 receptor: Chinese hamsters or Chinese whispers? Trends Pharmacol. Sci., 15:46-47.
8. Leff, S.E., Gariano, R., and Creese, I. (1984) Dopamine receptor turnover rates in rat striatum are age-dependent. Proc. Natl. Acad. Sci. U.S.A., 81:3910-3914.
9. 3H]7-OH-DPAT-labeled binding sites in rat brain to inactivation by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). Brain Res.
10. 3 receptors. Synapse, 14:90-95.
11. 3 dopamine receptors in rat brain and pituitary gland: A quantitative autoradiographic study. J. Pharmacol. Exp. Ther., 264:991-1001.
12. 3 dopamine receptors. Eur. J. Pharmacol., 278:243-247.
13. 3H]hydroxy-N,N-di-n-propyl-2-aminotetralin. Proc. Natl. Acad. Sci. U.S.A., 89:8155-8159.
14. Mallet, P.E., and Beninger, R.J. (1994) 7-OH-DPAT produces place conditioning in rats. Eur. J. Pharmacol., 261:R5-R6.
15. 2 receptor occupation by typical and atypical antipsychotic drugs in vivo. J. Pharmacol. Exp. Ther., 265:498-508.
16. 3-selective receptor ligand. Pharmacol. Biochem. Behav., 48:531-533.
17. 3-selective receptor ligand. Drug Dev. Res., 30:257-259.
18. 2 dopamine receptors by N-ethoxycarbonyl-2-ethoxy-dihydroquinoline in vivo: Selective protection by neuroleptics. J. Pharmacol, Exp. Ther., 233:656-662.
19. Nowak, G., Arnt, J., and Hyttel, J. (1989) EEDQ, a tool for ex vivo measurement of occupancy of D-1 and D-2 dopamine receptors. Eur. J. Pharmacol., 153:309-311.
20. 3H]NGD 94-1. Am. Coll. Neuropsychopharmacol. Abst., 174.
21. Saller, C.F., Kreamer, L.D., Adamovage, L.A., and Salama, A.I. (1989) Dopamine receptor occupancy in vivo: Measurement using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). Life Sci., 45:917-929.
22. Schotte, A., Janssen, P.F.M., Megens, A.A.H.P., and Leysen, J.E. (1993) Occupancy of central neurotransmitter receptors by risperidone, clozapine, and haloperidol, measured ex vivo by quantitative autoradiography. Brain Res., 631:191-202.
23. 2 receptor binding sites for agonists. A tetrahedral model. Mol. Pharmacol., 28:391-399.
24. 3) as a target for neuroleptics. Nature, 347:146-151.
25. 3 receptors. Eur. J. Pharmacol., 263:235-243.
26. 4 receptor with high affinity for the antipsychotic clozapine. Nature, 350:610-614.