Thermodynamics of a transition state analogue inhibitor binding to Escherichia coli chorismate mutase: Probing the charge state of an active site residue and its role in inhibitor binding and catalysis

Biochemistry

Volumn 37, Issue 25, 1998, Pages 9052-9057

  Lee, Angela Y ^a   Zhang, Sheng ^b   Kongsaeree, Palangpon ^b   Clardy, Jon ^b   Ganem, Bruce ^b   Erickson, John W ^a   Xie, Dong ^a  

^a SAIC FREDERICK INC   (United States)

^b Department of Molecular Biology and Genetics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORISMATE MUTASE; CHORISMIC ACID; ENZYME INHIBITOR;

ARTICLE; CATALYSIS; ENERGY TRANSFER; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; MOLECULAR RECOGNITION; MUTATION; NONHUMAN; PH; PRIORITY JOURNAL; THERMODYNAMICS;

AMINO ACID SUBSTITUTION; BINDING SITES; CALORIMETRY; CATALYSIS; CHORISMATE MUTASE; ENZYME INHIBITORS; ESCHERICHIA COLI; GLUTAMIC ACID; GLUTAMINE; HYDROGEN-ION CONCENTRATION; MUTAGENESIS, SITE-DIRECTED; PROTONS; THERMODYNAMICS;

ESCHERICHIA COLI;

EID: 0032560592     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980217u     Document Type: Article

References (27)

1. Haslam, E. (1993) Shikimic Acid: Metabolism and Metabolites, Wiley, New York.
2. Schmidheini, T., Mosch, H.-U., Evans, J., and Braus, G. (1990) Biochemistry 29, 3660-8.
3. Liu, D. R., Cload, S. T., Pastor, R. M., and Schultz, P. G. (1996) J. Am. Chem. Soc. 118, 1789-90.
4. Lee, A. Y., Stewart, J. D., Clardy, J., and Ganem, B. (1995) Chem. Biol. 2, 195-203.
5. Xue, Y., and Lipscomb, W. N. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 10595-8.
6. Schnappauf, G., Sträter, N., Lipscomb, W. N., and Braus, G. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 8491-6.
7. Cload, S. T., Liu, D. R., Pastor, R. M., and Schultz, P. G. (1996) J. Am. Chem. Soc. 118, 1787-8.
8. Zhang, S., Kongsaeree, P., Clardy, J., Wilson, D., and Ganem, B. (1996) Bioorg. Med. Chem. 4, 1015-20.
9. Baker, B., and Murphy, K. (1996) J. Mol. Biol. 268, 557-69.
10. Xie, D., Gulnik, S., Collins, L., Suvorov, L., Lee, A., Gustchina, E., and Erickson, J. (1997) Biochemistry 36, 16166-72.
11. Murphy, K. P., Xie, D., Garcia, K. C., Amzel, L. M., and Freire, E. (1993) Proteins: Struct., Funct., Genet. 15, 113-20.
12. Doyle, M. L., Louie, G., Dal Monte, P. R., and Sokoloski, T. D. (1995) Methods Enzymol. 259, 183-94.
13. Bartlett, P. A., and Johnson, C. R. (1995) J. Am. Chem. Soc. 107, 7792.
14. Stewart, J. D., Wilson, D. B., and Ganem, B. (1991) Tetrahedron 47, 2573.
15. Wiseman, T., Williston, S., Brandt, J., and Lin, L. (1989) Anal. Biochem. 179, 131-5.
16. Freire, E., Mayorga, O. L., and Straume, M. (1990) Anal. Chem. 62, 950A-9A.
17. Habermann, S., and Murphy, K. (1996) Protein Sci. 5, 1229-39.
18. Pace, N. (1995) Methods Enzymol. 259, 538-54.
19. Kato, Y., Conn, M., and Rebek, J. J. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 1208-12.
20. Murphy, K. P., and Freire, E. (1992) Adv. Protein Chem. 43, 313-61.
21. Murphy, K. P., and Gill, S. J. (1991) J. Mol. Biol. 222, 699-709.
22. Galopin, C. C., Zhang, S., Wilson, D. B., and Ganem, B. (1996) Tetrahedron Lett. 37, 8675-8.
23. Xie, D., Gulnik, S., Collins, L., Gustchina, E., Bhat, T. N., and Erickson, J. W. (1997) in Structure and Function of Aspartic Proteinases: Retroviral and Cellular Enzymes (James, M., Ed.) pp 381-6, Plenum, New York.
24. Turnbull, J., Cleland, W. W., and Morrison, J. F. (1991) Biochemistry 30, 7777-82.
25. Janin, J. (1997) Proteins: Struct., Funct., Genet. 28, 153-61.
26. Lee, A. Y., Karplus, P. A., Ganem, B., and Clardy, J. (1995) J. Am. Chem. Soc. 117, 3627-8.
27. Christensen, J. J., Hansen, L. D., and Izatt, R. M. (1976) Handbook of Proton Ionization Heats and Related Thermodynamic Quantities, Wiley, New York.