Efficient asymmetric syntheses of β-lactams bearing a cyclopropane or an epoxide moiety and their application to the syntheses of novel isoserines and taxoids

Journal of Organic Chemistry

Volumn 63, Issue 2, 1998, Pages 224-225

  Ojima, Iwao ^a   Lin, Songnian ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 PARAMETHOXYMETHYL 3 TRIISOPROPYLSILOXY 4 (2 METHYL 1 PROPENYL)BETA LACTAM; 1 TERT BUTOXYCARBONYL 3 TRIISOPROPYLSILOXY 4 (2 METHYL 1 PROPENYL)BETA LACTAM; BETA LACTAM ANTIBIOTIC; DOCETAXEL; PACLITAXEL; PACLITAXEL DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; DRUG CONFORMATION; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

EID: 0032559198     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo971908j     Document Type: Article

References (21)

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21. The cytotoxicity assays of 14 and 15 were carried out by Dr. Ralph J. Bernacki and Paula Pera, Department of Experimental Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute. Detailed biological data will be published elsewhere.