An investigation of bone marrow and testicular cells in vivo using the comet assay

Mutation Research - Genetic Toxicology

Volumn 370, Issue 3-4, 1996, Pages 159-174

  Anderson, Diana ^a   Dhawan, Alok ^b   Yu, Tian Wei ^a   Plewa, Michael J ^c  

^a BIBRA INTERNATIONAL   (United Kingdom)

^b CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYETHANOL; BLEOMYCIN; CYCLOPHOSPHAMIDE; MESYLIC ACID ETHYL ESTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; DRUG COMPARISON; DRUG SENSITIVITY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS; TESTIS; TISSUE SPECIFICITY;

ANIMALIA;

EID: 0344801351     PISSN: 01651218     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1218(96)00061-4     Document Type: Article

References (24)

1. 0 males. Terat. Carcinogen. Mutagen., 7, 141-158.
2. Anderson, D., T-W. Yu, B.J. Phillips and P. Schmezer (1994) The effect of various antioxidants and other modifying agents in oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay. Mutation Res., 307, 261-271.
3. Anderson, D., J. Bishop, C. Garner, P. Ostrosky-Wegman and P. Selby (1995) Cyclophosphamide: Review of its mutagenicity for an assessment of potential germ cell risks. Mutation Res., 330, 115-181.
4. Bloom, A.D. (Ed.) (1981) Guidelines for Studies of Human Populations exposed to Mutagenic and Reproductive Hazards. March of Dime Birth Defects Foundation. White Plains, N.Y.
5. Chiewchanwit, T. and W.W. Au (1994) Cytogenetic effects of 2-methoxyethanol and its metabolite, methoxyacetaldehyde, in mammalian cells in vitro. Mutation Res., 320 125-132.
6. Chiewchanwit T., H. Ma, R.E. Zein, L. Hallberg and W.W. Au (1995) Induction of deletion mutations by methoxyacetaldehyde in Chinese hamster ovary (CHO)-A552 cells. Mutation Res. 335, 121-128.
7. Croom, D.K., P.W. Andrews, B. Nascimbeni and R.R. Tice (1991) Evaluation of chemically induced DNA damage in germ cells of male mice using the single cell (SCG) assay. Environ. Mol. Mutagen., 17 (Suppl. 19), 19.
8. Dean, B.J., D. Anderson and R.J.S. Sram (1982) The Mutagenicity of Selected Chemicals in the Mammalian Dominant Lethal Assay in Comparative Chemical Mutagenesis. F.J. de Serres and M.D. Shelby (Eds.), Plenum Press. New York, pp. 487-538.
9. ECETOC (1995) Technical Report No. 64. The toxicology of glycol ethers and its relevance to man.
10. Foster, P.M.D., P.M. Creasy, J.R. Foster, L.V. Thomas, M.W. Cooke and S.D. Gangolli (1983) Testicular toxicity of ethylene glycol monomethyl and monoethyl ethers in the rat. Toxicol. Appl. Pharmacol., 69, 385-399.
11. Friend, J.H., T.D. Carpenter, R.R. Tice (1993) Evaluation of chemically induced DNA damage in germ cells of male mice using the single cell (SCG) assay. Environ. Mol. Mutagen, 21 (Suppl. 22), 20.
12. Hagmar, L., A. Brogger, I.-L. Hansteen, S. Heim, B. Högstedt, L. Knudsen, L. Lambert, K. Linnainmaa, F. Mitelman, I. Nordenson, C. Reuterwall, S. Salomaa, S. Skerfuing and M. Sorsa (1994) Cancer Risk in humans predicted by increased levels of chromosomal aberrations in lymphocytes: Nordic Study Group on the health risk of chromosome damage. Cancer Res., 54, 2919-2922.
13. Levin, D.E., M. Hollstein, M.F. Christman, E.A. Schwiers and B.A. Ames (1982) A new Salmonella tester strain (TA 102) with A-T base pairs at the site of mutation detects oxidative mutagens. Proc. Natl. Acad. Sci. USA, 79, 7445-7449.
14. Margolin, B.H., M.D. Shelby (1985) Sister chromatid exchanges. A re-examination of the evidence for sex and race differences in humans. Environ. Mutagen., 7, 63-72.
15. McGregor, D.B., M.J., Willins, P. McDonald, M. Holmström, D. McDonald and R.W. Niemeier (1983) Genetic effects of methoxyethanol and bis(2-methoxyethyl)ether. Toxicol. Appl. Pharmacol., 70, 303-316.
16. McKelvey-Martin, V.J., M.H.L. Green, P. Schmezer, B.L. Pool-Zobel, M.P. De Mes and A. Collins (1993) The single cell gel electrophoresis assay COMET assay: A European review. Mutation Res., 288, 47-63.
17. Pool-Zobel, B.L., B. Bertram, M. Knoll, R. Lambertz, C. Neudecker, U. Schillinger, P. Schmezer and W.H. Holzapfel (1993a) Antigenotoxic properties of lactic acid bacteria in vivo in the gastrointestinal tract of rats. Nutrition Cancer, 20, 271-281.
18. Pool-Zobel, B.L., C. Guigas, R.G. Klein, C.H. Neudecker, H.W. Renner and P. Schmezer (1993b) Assessment of genotoxic effects by lindane. Fd. Chem. Toxicol., 31, 271-283.
19. Sausville, E.A., R.W. Stein Peisach and S.B. Horwitz (1978) Properties and products of the degradation of DNA by bleomycin and iron. Biochemistry, 17, 2746-2754.
20. Schmezer, P., C. Eckart and U.M. Liegibel (1994) Tissue-specific induction of mutations of sptreptozotocin in vivo. Mutation Res., 307, 495-499.
21. Singh, N.P., M.T. McCoy, R.R. Tice and E.L. Schneider (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res., 175, 184-191.
22. Singh, N.P., D.B. Danner, R.R. Tice, M.T. McCoy, E.D. Collins and E.L. Schneider (1989) Abundant alkali-sensitive sites in DNA of human and mouse sperm. Exp. Cell Res., 184, 461-470.
23. Tice, R.R., G.H.S. Strauss and W.P. Peters (1992) High-dose combination alkylating agents with autologous bone-marrow support in patients with breast cancer - preliminary assessment of DNA damage in individual peripheral blood lymphocytes using the single cell gel electrophoresis assay. Mutation Res., 271, 101-113.
24. Umezawa, H., K. Meada, T. Takenchi and Y. Okami (1966) New antibiotics bleomycin A and B. J. Antibiotics, 19, 200-209.