1,2-benzisothiazol-3-one 1,1-dioxide inhibitors of human mast cell tryptase

Journal of Medicinal Chemistry

Volumn 41, Issue 24, 1998, Pages 4854-4860

  Combrink, Keith D ^a   Gülgeze, H Beigin ^a   Meanwell, Nicholas A ^a   Pearce, Bradley C ^a   Zulan, Pi ^a   Bisacchi, Gregory S ^a   Roberts, Daniel G M ^a   Stanley, Paul ^a   Seiler, Steven M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(1,1 DIOXIDO 3 OXO 1,2 BENZISOTHIAZOL 2(3H) YL)METHYL 4 [[(PHENYLMETHOXY)CARBONYL]AMINO]BENZOATE; (1,1 DIOXIDO 3 OXO 1,2 BENZISOTHIAZOL 2(3H) YL)METHYL 5 [[(PHENYLMETHOXY)CARBONYL]AMINO]PENTANOATE; (1,1 DIOXIDO 3 OXO 1,2 BENZISOTHIAZOL 2(3H) YL)METHYL N [(PHENYLMETHOXY)CARBONYL] BETA ALANATE; BLOOD CLOTTING FACTOR 10A; ENZYME INHIBITOR; PLASMIN; SACCHARIN DERIVATIVE; THROMBIN; TISSUE PLASMINOGEN ACTIVATOR; TRYPSIN; TRYPTASE; UNCLASSIFIED DRUG; UROKINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME KINETICS; FEMALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TOPICAL DRUG ADMINISTRATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHYMASES; CYCLIC S-OXIDES; DERMATITIS, CONTACT; FEMALE; HUMANS; HYPERSENSITIVITY, DELAYED; KINETICS; MAST CELLS; MICE; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TRYPTASES;

EID: 0032548001     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9804580     Document Type: Article

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