Monitoring solid phase reactions with ion-selective electrode

Tetrahedron Letters

Volumn 39, Issue 8, 1998, Pages 753-756

  Pátek, Marcel ^a   Bildstein, Sylvia ^a   Flegelová, Zuzana ^b  

^a Selectide Corporation   (United States)

^b BIOPHARM   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ANION; PERCHLORATE; PERCHLORIC ACID;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; ION SELECTIVE ELECTRODE; MONITORING; NONHUMAN; PEPTIDE SYNTHESIS; PROTON TRANSPORT; QUANTITATIVE ASSAY; SOLID PHASE EXTRACTION; TEMPERATURE;

EID: 0032546108     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)10617-7     Document Type: Article

References (23)

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17. 4 followed by multiple washings were performed in polypropylene syringes equiped with polyethylene frits.
18. 10. For easier calculation of concentration and error estimates, Microsoft Excel templates can be downloaded from the Molecular Diversity Webpage at http://www.5z.com/.
19. 11. Use of a combination electrode does not require an additional reference electrode since the indicating half-cell and reference half-cell are joined coaxially in a single body.
20. 4, which corresponds to ionic strength I=1M, is recommended for 1-50 mg of resin with loading 0.2-0.3mmol/g.
21. 13. Chloranil test was used to comfirm completion of the last coupling step (see, ref. 7).
22. 14. Flegelová, Z.; Pátek, M. J. Org. Chem. 1996, 61, 6735-6738.
23. 1H NMR). Structure identity was further confirmed by MS.