Inhibition of glycosaminoglycan modification of perlecan domain I by site-directed mutagenesis changes protease sensitivity and laminin-1 binding activity

FEBS Letters

Volumn 435, Issue 2-3, 1998, Pages 169-172

  Sasaki, Takako ^a   Costell, Mercedes ^b   Mann, Karlheinz ^a   Timpl, Rupert ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Basement membrane; Proteoglycan; Proteolysis; Recombinant protein; Site directed mutagenesis

Indexed keywords

GLYCOSAMINOGLYCAN; LAMININ; PERLECAN; PROTEINASE; RECOMBINANT PROTEIN;

ANIMAL TISSUE; ARTICLE; BINDING SITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SKELETAL MUSCLE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; ENDOPEPTIDASES; GLYCOSAMINOGLYCANS; HEPARAN SULFATE PROTEOGLYCANS; HEPARITIN SULFATE; LAMININ; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEOGLYCANS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

MAMMALIA;

EID: 0032544436     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(98)01063-1     Document Type: Article

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