Phosphorylation and spatiotemporal distribution of KW8 (NDRF/NeuroD2), a NeuroD family basic helix-loop-helix protein

Molecular Brain Research

Volumn 60, Issue 1, 1998, Pages 107-114

  Kume, Hideaki ^a   Maruyama, Kei ^a   Shinozaki, Kohki ^a   Kuzume, Hiroko ^a   Obata, Kunihiko ^a  

^a NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

Basic helix loop helix protein; Immunohistochemistry; Phosphorylation

Indexed keywords

ALKALINE PHOSPHATASE;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SLICE; CEREBELLUM; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOHISTOLOGY; LONG TERM POTENTIATION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; TISSUE DISTRIBUTION;

AGE FACTORS; ALKALINE PHOSPHATASE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOTTING, WESTERN; BRAIN CHEMISTRY; CLONING, MOLECULAR; GENE EXPRESSION; HELIX-LOOP-HELIX MOTIFS; NEURONS; NEUROPEPTIDES; PHOSPHORYLATION; PRECIPITIN TESTS; RATS; TRANSCRIPTION, GENETIC;

EID: 0032544358     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(98)00176-4     Document Type: Article

References (28)

1. Akazawa C., Ishibashi M., Shimizu C., Nakanishi S., Kageyama R. A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. J. Biol. Chem. 270:1995;8730-8738.
2. Bartholoma A., Nave K.A. NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons. Mech. Dev. 48:1994;217-228.
3. Braun T., Winter B., Bober E., Arnold H.H. Transcriptional activation domain of the muscle-specific gene-regulatory protein myf5. Nature. 346:1990;663-665.
4. Brennan T.J., Chakraborty T., Olson E.N. Mutagenesis of the myogenin basic region identifies an ancient protein motif critical for activation of myogenesis. Proc. Natl. Acad. Sci. USA. 88:1991;5675-5679.
5. Campos-Ortega J.A. Genetic mechanisms of early neurogenesis in Drosophila melanogaster. Mol. Neurobiol. 10:1995;75-89.
6. Caudy M., Vassin H., Brand M., Tuma R., Jan L.Y., Jan Y.N. Daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex. Cell. 55:1988;1061-1067.
7. Davis R.L., Weintraub H., Lassar A.B. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell. 51:1987;987-1000.
8. Jan Y.N., Jan L.Y. HLH proteins, fly neurogenesis, and vertebrate myogenesis. Cell. 75:1993;827-830.
9. Johnson J.E., Birren S.J., Anderson D.J. Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors. Nature. 346:1990;858-861.
10. Kume H., Maruyama K., Tomita T., Iwatsubo T., Saido T.C., Obata K. Molecular cloning of a novel basic helix-loop-helix protein from the rat brain. Biochemical and Biophysical Research Communications. 219:1996;526-530.
11. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
12. Lee J.E., Hollenberg S.M., Snider L., Turner D.L., Lipnick N., Weintraub H. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science. 268:1995;836-844.
13. Li L., Heller-Harrison R., Czech M., Olson E.N. Cyclic AMP-dependent protein kinase inhibits the activity of myogenic helix-loop-helix proteins. Mol. Cell. Biol. 12:1992;4478-4485.
14. Li L., Zhou J., James G., Heller-Harrison R., Czech M.P., Olson E.N. FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains. Cell. 71:1992;1181-1194.
15. Maruyama K., Terakado K., Usami M., Yoshikawa K. Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor. Nature. 347:1990;566-569.
16. Maruyama K., Tagawa K., Kawamura Y., Asada H., Ishiura S., Obata K. Secretion of Alzheimer beta/A4 protein (1-40) and intracellular retention of beta/A4 protein (1-42) in transfected COS cells. Biochemical and Biophysical Research Communications. 207:1995;971-977.
17. McCormick M.B., Tamimi R.M., Snider L., Asakura A., Bergstrom D., Tapscott S.J. NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family. Mol. Cell. Biol. 16:1996;5792-5800.
18. Naya F.J., Huang H.P., Qiu Y., Mutoh H., DeMayo F.J., Leiter A.B., Tsai M.J. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 11:1997;2323-2334.
19. Naya F.J., Stellrecht C.M., Tsai M.J. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev. 9:1995;1009-1019.
20. Rhodes S.J., Konieczny S.F. Identification of MRF4: a new member of the muscle regulatory factor gene family. Genes Dev. 3:1989;2050-2061.
21. Sasai Y., Kageyama R., Tagawa Y., Shigemoto R., Nakanishi S. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev. 6:1992;2620-2634.
22. Schwab M.H., Druffel-Augustin S., Gass P., Jung M., Klugmann M., Bartholomae A., Rossner M.J., Nave K.A. Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice. J. Neurosci. 18:1998;1408-1418.
23. Shimizu C., Akazawa C., Nakanishi S., Kageyama R. MATH-2, a mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal, is specifically expressed in the nervous system. Eur. J. Biochem. 229:1995;239-248.
24. Takebayashi K., Takahashi S., Yokota C., Tsuda H., Nakanishi S., Asashima M., Kageyama R. Conversion of ectoderm into a neural fate by ATH-3, a vertebrate basic helix-loop-helix gene homologous to Drosophila proneural gene atonal. EMBO J. 16:1997;384-395.
25. Winter B., Braun T., Arnold H.H. cAMP-dependent protein kinase represses myogenic differentiation and the activity of the muscle-specific helix-loop-helix transcription factors Myf-5 and MyoD. J. Biol. Chem. 268:1993;9869-9878.
26. Wright W.E., Sassoon D.A., Lin V.K. Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD. Cell. 56:1989;607-617.
27. Yasunami M., Suzuki K., Maruyama H., Kawakami H., Nagai Y., Hagiwara M., Ohkubo H. Molecular cloning and characterization of a cDNA encoding a novel basic helix-loop-helix protein structurally related to Neuro-D/BHF1. Biochemical and Biophysical Research Communications. 220:1996;754-758.
28. Zhou J., Olson E.N. Dimerization through the helix-loop-helix motif enhances phosphorylation of the transcription activation domains of myogenin. Mol. Cell. Biol. 14:1994;6232-6243.