Synthesis of novel substituted pyridines as inhibitors of endothelin converting enzyme-1 (ECE-1)

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 16, 1998, Pages 2117-2122

  Massa, Mark A ^a   Patt, William C ^a   Ahn, Kyunghye ^b   Sisneros, Andre M ^b   Herman, Sarah B ^b   Doherty, Annette ^a  

^a Chemistry Department   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; ENDOTHELIN; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN CONVERTING ENZYME INHIBITOR; PYRIDINE DERIVATIVE;

ARTICLE; BLOOD VESSEL REACTIVITY; CEREBROVASCULAR ACCIDENT; DRUG SYNTHESIS; HYPERTENSION; ISCHEMIA; KIDNEY FAILURE; MOLECULAR INTERACTION;

ANIMALS; ASPARTIC ENDOPEPTIDASES; CHO CELLS; CRICETINAE; ENZYME INHIBITORS; HUMANS; INDICATORS AND REAGENTS; KINETICS; METALLOENDOPEPTIDASES; PALLADIUM; PROTEASE INHIBITORS; PYRIDINES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0032544132     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00375-8     Document Type: Article

References (18)

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18. += 341.1. mp= 104-106 °C.