Beyond erythropoietin: The oxygen sensor

Nephrology Dialysis Transplantation

Volumn 12, Issue 9, 1997, Pages 1842-1848

  Ratcliffe, P J ^a   Maxwell, P H ^a   Pugh, C W ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HEMOGLOBIN; HYPOXIA INDUCIBLE FACTOR 1; RECOMBINANT ERYTHROPOIETIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

BIOSENSOR; CONTROLLED STUDY; DRUG MECHANISM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIC CELL; KIDNEY DISEASE; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN DNA BINDING; SENSOR; SHORT SURVEY; TISSUE OXYGENATION;

CHEMORECEPTORS; DNA-BINDING PROTEINS; ERYTHROPOIETIN; FEEDBACK; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NUCLEAR PROTEINS; OXYGEN; TRANSCRIPTION FACTORS;

EID: 0030865533     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/12.9.1842     Document Type: Short Survey

References (54)

1. Goldberg MA, Dunning SP, Bunn HF. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 1988; 242: 1412-1415
2. Beck I, Ramirez S, Weinmann R, Caro J. Enhancer element at the 3′-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene. J Biol Chem 1991; 266: 15563-15566
3. Semenza GL, Nejfelt MK, Chi SM, Antonarakis SE. Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene. Proc Natl Acad Sci USA 1991; 88: 5680-5684
4. Pugh CW, Tan CC, Jones RW, Ratcliffe PJ. Functional analysis of an oxygen-related transcriptional enhancer lying 3′ to the mouse erythropoietin gene. Proc Natl Acad Sci USA 1991; 88: 10553-10557
5. Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992; 12: 5447-5454
6. Maxwell PH, Pugh CW, Ratcliffe PJ. Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: evidence for a widespread oxygen sensing mechanism. Proc Natl Acad Sci USA 1993; 90: 2423-2427
7. Wang GL, Semenza GL. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA 1993; 90: 4304-4308
8. Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoeitin 3′ enhancer. Proc Natl Acad Sci USA 1994; 91: 6496-6500
9. Ebert BL, Firth JD, Ratcliffe PJ. Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct cis-acting sequences. J Biol Chem 1995; 270: 29083-29089
10. Kietzmann T, Schmidt H, Unthan FK, Probst I, Jungermann K. A ferro-heme protein senses oxygen levels, which modulate the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures. Biochem Biophys Res Commun 1993; 195: 792-798
11. 2-responsive sequences on the tyrosine hydroxylase gene. J Biol Chem 1995; 270: 23774-23779
12. Kourembanas S, Marsden PA, McQuillan LP, Faller DV. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J Clin Invest 1991; 88: 1054-1057
13. McQuillan LP, Leung GK, Marsden PA, Kostyk SK, Kourembanas S. Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms. Am J Physiol 1994; 267: H1921-H1927
14. Levy AP, Levy NS, Wegner S, Goldberg MA. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 1995; 270: 13333-13340
15. Wenger RH, Rolfs A, Marti HH, Bauer C, Gassmann M. Hypoxia, a novel inducer of acute phase expression in a human hepatoma cell line. J Biol Chem 1995; 270: 27865-27870
16. Wood SM, Gleadle JM, Pugh CW, Hankinson O, Ratcliffe PJ. The role of aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression: studies in ARNT deficient cells. J Biol Chem 1996; 271: 15117-15123
17. Weir EK, Archer SL. The mechanisms of acute hypoxic pulmonary vasoconstriction: the tale of two channels. FASEB J 1995; 9: 183-189
18. Archer SL, Huang JMC, Reeve HL et al. Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia. Circ Res 1995; 78: 431-442
19. k (A) channels by cysteine oxidation. Nature 1991; 352: 711-714
20. 2 tension. Proc Natl Acad Sci USA 1995; 92: 5510-5514
21. Reyes H, Reisz-Porszasz S, Hankinson O. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 1992; 256: 1193-1195
22. Hankinson O. Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase. Proc Natl Acad Sci USA 1979; 76: 373-376
23. Hoffman EC, Reyes H, Chu F-F et al. Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 1991; 252: 954-958
24. Li H, Ko HP, Whitlock JP Jr. Induction of phosphoglycerate kinase 1 gene expression by hypoxia. J Biol Chem 1996; 271: 21262-21267
25. 2 tension. Am J Physiol 1996; 271: C1172-C1180
26. Tan CC, Eckardt K-U, Firth JD, Ratcliffe PJ. Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia. Am J Physiol 1992; 263: F474-F481
27. Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359: 843-845
28. Plate KH, Breier G, Weich HA, Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992; 359: 845-848
29. Sandner P, Gess B, Wolf K, Kurtz A. Divergent regulation of vascular endothelial growth factor and of erythropoietin gene expression in vivo. Pflügers Arch 1996; 431: 905-912
30. Gleadle JM, Ebert BL, Firth JD, Ratcliffe PJ. Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents. Am J Physiol 1995; 268: C1362-C1368
31. Galson DL, Tsuchiya T, Tendler DS et al. The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1. Mol Cell Biol 1995; 15: 2135-2144
32. Firth JD, Ebert BL, Ratcliffe PJ. Hypoxic regulation of lactate dehydrogenase A: interaction between hypoxia inducible factor 1 and cAMP response elements. J Biol Chem 1995; 270: 21021-21027
33. Mazure NM, Chen EY, Yeh P, Laderoute KR, Giaccia AJ. Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res 1996; 56: 3436-3440
34. Dachs GU, Patterson AV, Firth JD et al. Targeting gene expression to hypoxic tumour cells. Nature Med 1997; 3: 515-520
35. Webster KA, Discher DJ, Bishopric NH. Regulation of fos and jun immediate-early genes by redox or metabolic stress in cardiac myocytes. Circ Res 1994; 74: 679-686
36. Koong AC, Chen EY, Mivechi NF et al. Hypoxic activation of nuclear factor-κB is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2). Cancer Res 1994; 54: 5273-5279
37. Czyzyk-Krzeska MF, Dominski Z, Kole R, Millhorn DE. Hypoxia stimulates binding of a cytoplasmic protein to a pyrimidine-rich sequence in the 3′-untranslated region of rat tyrosine hydroxylase mRNA. J Biol Chem 1994; 269: 9940-9945
38. Levy AP, Levy NS, Goldberg MA. Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau protein. J Biol Chem 1996; 271: 25492-25497
39. Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 1997; 11: 72-82
40. Gradin K, McGuire J, Wenger RH et al. Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Mol Cell Biol 1996; 16: 5221-5231
41. Huang LE, Arany Z, Livingston DM, Bunn HF. Activation of hypoxia-inducible transcription factor depends primarily on redox-sensitive stabilization of its α subunit. J Biol Chem 1996; 271: 32253-32259
42. Pugh CW, O'Rourke JF, Nagao M, Gleadle JM, Ratcliffe PJ. Activation of hypoxia inducible factor-1; definition of regulatory domains within the a subunit. J Biol Chem 1997; 272: 11205-11214
43. Jiang B-H, Rue E, Wang GL, Roe R, Semenza GL. Dimerization, DNA binding and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 1996; 271; 17771-17778
44. Wang GL, Jiang B-H, Semenza GL. Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. Biochem Biophys Res Commun 1995; 216; 669-675
45. Wang GL, Jiang B-H, Semenza GL. Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1. Biochem Biophys Res Commun 1995; 212: 550-556
46. Gilles-Gonzalez MA, Ditta GS, Helinski DR. A haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium meliloti. Nature 1991; 350: 170-172
47. Fandrey J, Frede S, Jelkmann W. Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem J 1994; 303: 507-510
48. Gleadle JM, Ebert BL, Ratcliife PJ. Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia: implications for the mechanism of oxygen sensing. Eur J Biochem 1995; 234: 92-99
49. O'Donnell VB, Tew DG, Jones OTG, England PJ. Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase. Biochem J 1993; 290: 41-49
50. Acker H. Mechanisms and meaning of cellular oxygen sensing in the organism. Respir Physiol 1994; 95: 1-10
51. 2 sensor protein in the rat carotid body. Biochem J 1990; 272: 743-747
52. Wenger RH, Marti HH, Schuerer-Maly CC et al. Hypoxic induction of gene expression in chronic granulomatous disease-derived B-cell lines: oxygen sensing is independent of the cytochrome b558-containing nicotinamide adenine dinucleotide phosphate oxidase. Blood 1996; 87: 756-761
53. Poole RK, Ioannidis N, Orii Y. Reactions of the Escherichia coli flavohaemoglobin (Hmp) with oxygen and reduced nicotinamide adenine dinucleotide: evidence for oxygen switching of flavin oxidoreduction and a mechanism for oxygen sensing. Proc Roy Soc Lond Biol 1994; 255: 251-258
54. Maxwell, PH, Dachs GV, Gleade JM et al. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 1997; 94: in press