Use of herpes simplex virus thymidine kinase to improve the antiviral activity of zidovudine

Virology

Volumn 235, Issue 2, 1997, Pages 398-405

  Guettari, N ^a   Loubiere L ^a   Brisson, E ^a   Klatzmann, D ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FOSCARNET; THYMIDINE KINASE; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; GENE TRANSFER; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL;

HERPES; HUMAN HERPESVIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SIMPLEXVIRUS;

EID: 0343052856     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1997.8706     Document Type: Article

References (26)

1. Balzarini J., Pauwels R., Baba M., Herdewijn P., De Clercq E., Broder S., Johns D. G. The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3′-azido-2′,3′-dideoxythymidine and 2′,3′-dideoxycytidine are highly dependent on the cell species. Biochem. Parmacol. 37:1988;897-903.
2. Bridges E. G., Faraj A., Sommadossi J. P. Inhibition of mammalian DNA polymerase-associated 3′ to 5′ exonuclease activity by 5′-monophosphates of 3′-azido-3′-deoxythymidine and 3′-amino-3′-deoxythymidine. Biochem. Pharmacol. 45:1993;1571-1576.
3. Caruso M., Klatzmann D. Selective killing of CD4+ cells harboring a human immunodeficiency virus-inducible suicide gene prevents viral spread in an infected cell population. Proc. Natl. Acad. Sci. USA. 89:1992;182-186.
4. Caruso M., Klatzmann D. [Genetically controlled pharmacomodulation for HIV gene therapy] Pharmacomodulation contrôlée génétiquement: Application au traitement de l'infection par le VIH. C. R. Acad. Sci. Paris Sci. Vie/Life Sci. 317:1994;1027-1030.
5. Caruso M., Panis Y., Gagandeep S., Houssin D., Salzmann J. L., Klatzmann D. Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc. Natl. Acad. Sci. USA. 90:1993;7024-7028.
6. Caruso M., Salomon B., Zhang S., Brisson E., Clavel F., Lowy I., Klatzmann D. Expression of a Tat-inducible herpes simplex virus-thymidine kinase gene protects acyclovir-treated CD4 cells from HIV-1 spread by conditional suicide and inhibition of reverse transcription. Virology. 206:1995;495-503.
7. Chen M. S., Prusoff W. H. Association of thymidylate kinase activity with pyrimidine deoxyribonucleoside kinase induced by herpes simplex virus. J. Biol. Chem. 253:1978;1325-1327.
8. Collier A., Coombs R., Schoenfeld D., Bassett R., Timpone J., Baruch A., Jones M., Facey K., Whitacre C., McAuliffe V., Friedman H., Merigan T., Reichman R., Hooper C., Corey L. Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. AIDS Clinical Trials Group. N. Engl. J. Med. 334:1996;1011-1017.
9. Lancet. 348:1996;283-291.
10. Dolin R., Lambert J. S., Morse G. D., Reichman R. C., Plank C. S., Reid J., Knupp C., McLaren C., Pettinelli C. 2′,3′-Dideoxyinosine in patients with AIDS or AIDS-related complex. Rev. Infect. Dis. 12:1990;S540-S549.
11. Dubinsky R. M., Yarchoan R., Dalakas M., Broder S. Reversible axonal neuropathy from the treatment of AIDS and related disorders with 2′,3′-dideoxycytidine (ddC). Muscle Nerve. 12:1989;856-860.
12. Furman P. A., Fyfe J. A., St. Clair M. H., Weinhold K., Rideout J. L., Freeman G. A., Lehrman S. N., Bolognesi D. P., Broder S., Mitsuya H. Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase. Proc. Natl. Acad. Sci. USA. 83:1986;8333-8337.
13. Hammer S. M., Katzenstein D. A., Hughes M. D., Gundacker H., Schooley R. T., Haubrich R. H., Henry W. K., Lederman M. M., Phair J. P., Niu M., Hirsch M. S., Merigan T. C. A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter. AIDS Clinical Trials Group Study 175 Study Team. N. Engl. J. Med. 335:1996;1081-1090.
14. Harrington J. A., Reardon J. E., Spector T. 3′-azido-3′-deoxythymidine (AZT) monophosphate: An inhibitor of exonucleolytic repair of AZT-terminated DNA. Antimicrob. Agents Chemother. 37:1993;918-920.
15. Ho H.-T., Hitchcock M. J. M. Cellular pharmacology of 2′,3′-dideoxy-2′,3′-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus. Antimicrob. Agents Chemother. 33:1989;844-849.
16. Jacobsson B., Britton S., He Q., Karlsson A., Eriksson S. Decreased thymidine kinase levels in peripheral blood cells from HIV-seropositive individuals: Implications for zidovudine metabolism. AIDS Res. Hum. Retroviruses. 11:1995;805-811.
17. Jamieson A., Gentry G., Subak-Sharpe J. Induction of both thymidine and deoxycytidine kinase activity by herpes viruses. J. Gen. Virol. 24:1974;465-480.
18. Kremmer T., Paulik E., Boldizsar M., Holenyi I. Application of the fast protein liquid chromatographic system and MonoQ HR 5/5 anion exchanger to the separation of nucleosides. J. Chromatogr. 493:1989;45-52.
19. Medina D. J., Tung P. P., Lerner-Tung M. B., Nelson C. J., Mellors J. W., Strair R. K. Sanctuary growth of human immunodeficiency virus in the presence of 3′-azido-3′-deoxythymidine. J. Virol. 69:1995;1606-1611.
20. Mukherji E., Au J. L.-S., Mathes L. E. Differential antiviral activities and intracellular metabolism of 2′,3′-dideoxyinosine in human cells. Antimicrob. Agents Chemother. 38:1994;1573-1579.
21. Perno C.-F., Yarchoan R., Cooney D. A., Hartman N. R., Gartner S., Popovic M., Hao Z., Gerrard T. L., Wilson Y. A., Johns D. G., Broder S. Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3′-azido-2′3′-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine. J. Exp. Med. 169:1989;933-951.
22. Richman D. D., Fischl M. A., Grieco M. H., Gottlieb M. S., Volberding P. A., Laskin O. L., Leedom J. M., Groopman J. E., Mildvan D., Hirsch M. S. The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. N. Engl. J. Med. 317:1987;192-197.
23. Robertson G. R., Whalley J. M. Evolution of the herpes thymidine kinase: Identification and comparison of the equine herpesvirus 1 thymidine kinase gene reveals similarity to a cell-encoded thymidylate kinase. Nucleic Acids Res. 16:1988;11303-11317.
24. Sommadossi J. Nucleoside analogs: Similarities and differences. Clin. Infect. Dis. 16:1993;7-15.
25. St. Clair M. H., Richards C. A., Spector T., Weinhold K. J., Miller W. H., Langlois A. J., Furman P. A. 3′-Azido-3′-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase. Antimicrob. Agents Chemother. 31:1987;1972-1977.
26. Yarchoan R., Pluda J., Perno C., Mitsuya H., Broder S. Anti-retroviral therapy of human immunodeficiency virus infection: Current strategies and challenges for the future. Blood. 78:1991;859-884.