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Volumn 7, Issue 3, 1996, Pages 291-296

Pharmacokinetics, metabolism and tumour disposition of 8-chloroadenosine 3′,5′-monophosphate in breast cancer patients and xenograft bearing mice

Author keywords

8 chloroadenosine 3 ,5 monophosphate (8 Cl cAMP); Metabolism; Pharmacokinetics; Tumour biopsies; Xenografts

Indexed keywords

8 CHLOROADENOSINE; 8 CHLOROADENOSINE 3',5' PHOSPHATE; DRUG METABOLITE; PRODRUG; UNCLASSIFIED DRUG;

EID: 0029874761     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.annonc.a010574     Document Type: Article
Times cited : (23)

References (28)
  • 1
    • 0024418926 scopus 로고
    • Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by site-selective 8-Cl-cyclic adenosine monophosphate
    • Ally S, Clair T, Katsaros D et al. Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by site-selective 8-Cl-cyclic adenosine monophosphate. Cancer Res 1989; 49: 5650-5.
    • (1989) Cancer Res , vol.49 , pp. 5650-5655
    • Ally, S.1    Clair, T.2    Katsaros, D.3
  • 2
    • 0025222504 scopus 로고
    • Perspectives in cancer research: Role of cyclic AMP receptor proteins in growth, differentiation and suppression of malignancy: New approaches to therapy
    • Cho-Chung YS. Perspectives in cancer research: Role of cyclic AMP receptor proteins in growth, differentiation and suppression of malignancy: New approaches to therapy. Cancer Res 1990; 50: 7093-100.
    • (1990) Cancer Res , vol.50 , pp. 7093-7100
    • Cho-Chung, Y.S.1
  • 3
    • 0027858371 scopus 로고
    • The regulatory subunit of cAMP-dependent protein kinase as a target for chemotherapy of cancer and other cellular dysfunctional-related diseases
    • Cho-Chung YS, Clair T. The regulatory subunit of cAMP-dependent protein kinase as a target for chemotherapy of cancer and other cellular dysfunctional-related diseases. Pharmacol Ther 1993; 60: 265-88.
    • (1993) Pharmacol Ther , vol.60 , pp. 265-288
    • Cho-Chung, Y.S.1    Clair, T.2
  • 4
    • 0024415774 scopus 로고
    • Site selective cyclic AMP analogs as new biological tools in growth control, differentiation, and proto-oncogene regulation
    • Cho-Chung YS, Clair T, Tagliaferri P et al. Site selective cyclic AMP analogs as new biological tools in growth control, differentiation, and proto-oncogene regulation. Cancer Invest 1989; 7: 161-77.
    • (1989) Cancer Invest , vol.7 , pp. 161-177
    • Cho-Chung, Y.S.1    Clair, T.2    Tagliaferri, P.3
  • 5
    • 0025972556 scopus 로고
    • Cyclic adenosine 3′,5′-monophosphate binding proteins in human colorectal cancer and mucosa
    • Bradbury AW, Miller WR, Carter DC. Cyclic adenosine 3′,5′-monophosphate binding proteins in human colorectal cancer and mucosa. Br J Cancer 1991; 63: 201-4.
    • (1991) Br J Cancer , vol.63 , pp. 201-204
    • Bradbury, A.W.1    Miller, W.R.2    Carter, D.C.3
  • 6
    • 0025753771 scopus 로고
    • 8-Chloroadenosine 3′,5′-monophosphate inhibits the growth of chinese hamster ovary and MOLT-4 cells through its adenosine metabolite
    • Van Lookeren Campagne MM, Diaz FV, Jastroff B et al. 8-Chloroadenosine 3′,5′-monophosphate inhibits the growth of chinese hamster ovary and MOLT-4 cells through its adenosine metabolite. Cancer Res 1991; 51: 1600-5.
    • (1991) Cancer Res , vol.51 , pp. 1600-1605
    • Van Lookeren Campagne, M.M.1    Diaz, F.V.2    Jastroff, B.3
  • 7
    • 0026764144 scopus 로고
    • Growth inhibition of human glioma cells induced by chloroadenosine, an active metabolite of 8-chloro cyclic adenosine 3′,5′-monophosphate
    • Langeveld CH, Jongenlen CAM, Heimans JJ et al. Growth inhibition of human glioma cells induced by chloroadenosine, an active metabolite of 8-chloro cyclic adenosine 3′,5′-monophosphate. Cancer Res 1992; 52: 3994-9.
    • (1992) Cancer Res , vol.52 , pp. 3994-3999
    • Langeveld, C.H.1    Jongenlen, C.A.M.2    Heimans, J.J.3
  • 8
    • 0026782535 scopus 로고
    • Inhibition of colon tumour cell growth by 8-chloro-cAMP is dependent upon its conversion to 8-chloro-adenosine
    • Taylor CW, Yeoman LC. Inhibition of colon tumour cell growth by 8-chloro-cAMP is dependent upon its conversion to 8-chloro-adenosine. Anti-Cancer Drugs 1992; 3: 485-91.
    • (1992) Anti-Cancer Drugs , vol.3 , pp. 485-491
    • Taylor, C.W.1    Yeoman, L.C.2
  • 9
    • 0028026866 scopus 로고
    • Effects of 8-chloro-cyclic adenosine monophosphate on the growth and sensitivity to doxorubicin of multidrug-resistant tumour cell lines
    • Borsellino N, Crescimanno M, Leonardi V et al. Effects of 8-chloro-cyclic adenosine monophosphate on the growth and sensitivity to doxorubicin of multidrug-resistant tumour cell lines. Pharmacol Res 1994; 30: 81-90.
    • (1994) Pharmacol Res , vol.30 , pp. 81-90
    • Borsellino, N.1    Crescimanno, M.2    Leonardi, V.3
  • 10
    • 0021846147 scopus 로고
    • Metabolism and metabolic effects of halopurine nucleosides in tumour cells in culture
    • Bennett Jr LL, Chang C-H, Allan PW et al. Metabolism and metabolic effects of halopurine nucleosides in tumour cells in culture. Nucleosides and Nucleotides 1985; 4: 107-16.
    • (1985) Nucleosides and Nucleotides , vol.4 , pp. 107-116
    • Bennett Jr., L.L.1    Chang, C.-H.2    Allan, P.W.3
  • 11
    • 0023930781 scopus 로고
    • Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues
    • Tagliaferri P, Katsaros D, Clair T et al. Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues. Cancer Res 1988; 48: 1642-50.
    • (1988) Cancer Res , vol.48 , pp. 1642-1650
    • Tagliaferri, P.1    Katsaros, D.2    Clair, T.3
  • 12
    • 0027509430 scopus 로고
    • 8-Chloroadenosine mediates 8-chloro-cyclic AMP-induced down regulation of cyclic AMP-dependent protein kinase in normal and neoplastic mouse lung epithelial cells by a cyclic AMP-independent mechanism
    • Lange-Carter CA, Vuillequez JJ, Malkinson AM. 8-Chloroadenosine mediates 8-chloro-cyclic AMP-induced down regulation of cyclic AMP-dependent protein kinase in normal and neoplastic mouse lung epithelial cells by a cyclic AMP-independent mechanism. Cancer Res 1993; 53: 393-400.
    • (1993) Cancer Res , vol.53 , pp. 393-400
    • Lange-Carter, C.A.1    Vuillequez, J.J.2    Malkinson, A.M.3
  • 13
    • 0026334554 scopus 로고
    • Letter to Editor
    • Cho-Chung YS. Letter to Editor. Cancer Res 1991; 51: 6206-8.
    • (1991) Cancer Res , vol.51 , pp. 6206-6208
    • Cho-Chung, Y.S.1
  • 15
    • 0342473653 scopus 로고
    • Preclinical pharmaceutical analysis and preliminary clinical pharmacokinetics of the signal transduction pathway modulator, 8-Cl cAMP
    • Cummings J. Leonard RCF, Miller WR. Preclinical pharmaceutical analysis and preliminary clinical pharmacokinetics of the signal transduction pathway modulator, 8-Cl cAMP. Ann Oncol 1994; 5 (Suppl 5): 178.
    • (1994) Ann Oncol , vol.5 , Issue.5 SUPPL. , pp. 178
    • Cummings, J.1    Leonard, R.C.F.2    Miller, W.R.3
  • 17
    • 0028948435 scopus 로고
    • Phase I clinical study with 8-chloro-cAMP and evaluation of immunological effects in cancer patients
    • Tortora G, Ciardiello F, Pepe S et al. Phase I clinical study with 8-chloro-cAMP and evaluation of immunological effects in cancer patients. Clin Cancer Res 1995; 1: 377-84.
    • (1995) Clin Cancer Res , vol.1 , pp. 377-384
    • Tortora, G.1    Ciardiello, F.2    Pepe, S.3
  • 18
    • 0028092926 scopus 로고
    • Sensitive determination of 8-chloroadenosine 3′,5′-monophosphate and 8-chloroadenosine in plasma by high-performance liquid chromatography
    • Cummings J, Leonard RCF, Miller WR. Sensitive determination of 8-chloroadenosine 3′,5′-monophosphate and 8-chloroadenosine in plasma by high-performance liquid chromatography. J Chromatogr 1994; B 658: 183-8.
    • (1994) J Chromatogr , vol.B 658 , pp. 183-188
    • Cummings, J.1    Leonard, R.C.F.2    Miller, W.R.3
  • 19
    • 0028054784 scopus 로고
    • Cyclic adenosine 3′,5′-monophosphate-binding proteins in human ovarian cancers
    • Ramage AD, Burns DJ, Miller WR. Cyclic adenosine 3′,5′-monophosphate-binding proteins in human ovarian cancers. Br J Cancer 1994; 69: 186-90.
    • (1994) Br J Cancer , vol.69 , pp. 186-190
    • Ramage, A.D.1    Burns, D.J.2    Miller, W.R.3
  • 20
    • 3142617038 scopus 로고
    • Kinetics and toxicity of 8-chloroadenosine-3′,5′-cyclic monophosphate (8-Cl-cAMP) in beagle dogs
    • Dixit R, Lopez R, Douglas T et al. Kinetics and toxicity of 8-chloroadenosine-3′,5′-cyclic monophosphate (8-Cl-cAMP) in beagle dogs. Proc Am Assoc Cancer Res 1990; 31: 384.
    • (1990) Proc Am Assoc Cancer Res , vol.31 , pp. 384
    • Dixit, R.1    Lopez, R.2    Douglas, T.3
  • 21
    • 0010524472 scopus 로고
    • Plasma drug levels and toxicity produced by intravenous infusions of 8-chloro-cyclic AMP (8-Cl-cAMP, NSC-614491) to beagle dogs
    • Tomasewski JE, Sparks RM, Rose LM et al. Plasma drug levels and toxicity produced by intravenous infusions of 8-chloro-cyclic AMP (8-Cl-cAMP, NSC-614491) to beagle dogs. Proc Am Assoc Cancer Res 1991; 32: 425.
    • (1991) Proc Am Assoc Cancer Res , vol.32 , pp. 425
    • Tomasewski, J.E.1    Sparks, R.M.2    Rose, L.M.3
  • 22
    • 0342473651 scopus 로고
    • 3H]-S-Cl-cAMP in mice by whole-body autoradiography of cryosections
    • 3H]-S-Cl-cAMP in mice by whole-body autoradiography of cryosections. Proc Am Assoc Cancer Res 1990; 31: 382.
    • (1990) Proc Am Assoc Cancer Res , vol.31 , pp. 382
    • Malspeis, L.1    Kemmenoe, B.H.2
  • 23
    • 0025775108 scopus 로고
    • Role of site selective cAMP analogues in the control and reversal of malignancy
    • Cho-Chung YS, Clair T, Tortora G et al. Role of site selective cAMP analogues in the control and reversal of malignancy. Pharmacol Ther 1990; 50: 1-33.
    • (1990) Pharmacol Ther , vol.50 , pp. 1-33
    • Cho-Chung, Y.S.1    Clair, T.2    Tortora, G.3
  • 24
    • 0025070111 scopus 로고
    • 8-Cl-cAMP inhibits transforming growth factor a transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation
    • Ciardiello F, Tortora G, Kim N et al. 8-Cl-cAMP inhibits transforming growth factor a transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation. J Biol Chem 1990; 265: 1016-20.
    • (1990) J Biol Chem , vol.265 , pp. 1016-1020
    • Ciardiello, F.1    Tortora, G.2    Kim, N.3
  • 25
    • 0025980027 scopus 로고
    • Differentiation of HL-60 leukaemia by type I regulatory subunit antisense oligonucleotide of cAMP-dependent protein kinase
    • Tortora G, Yokozaki H, Pepe S et al. Differentiation of HL-60 leukaemia by type I regulatory subunit antisense oligonucleotide of cAMP-dependent protein kinase. Proc Natl Acad Sci USA 1991; 88: 2011-5.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 2011-2015
    • Tortora, G.1    Yokozaki, H.2    Pepe, S.3
  • 26
    • 0026781533 scopus 로고
    • Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukaemia patients by site selective 8-chloro-cyclic adenosine 3′,5′-monophosphate (8-Cl-cAMP)
    • Pinto A, Aldinucci D, Gattei V et al. Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukaemia patients by site selective 8-chloro-cyclic adenosine 3′,5′-monophosphate (8-Cl-cAMP). Proc Natl Acad Sci USA 1992; 89: 8884-8.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 8884-8888
    • Pinto, A.1    Aldinucci, D.2    Gattei, V.3
  • 27
    • 0027268671 scopus 로고
    • 8-Chloroadenosine 3′,5′-monophosphate as a novel modulator of multidrug resistance
    • Yokozaki H, Budillon A, Clair T et al. 8-Chloroadenosine 3′,5′-monophosphate as a novel modulator of multidrug resistance. Int J Oncol 1993; 3: 423-30.
    • (1993) Int J Oncol , vol.3 , pp. 423-430
    • Yokozaki, H.1    Budillon, A.2    Clair, T.3
  • 28
    • 0027457819 scopus 로고
    • Reversal of resistance to adriamycin by 8-chloro-cyclic AMP in adriamycin-resistant HL-60 leukaemia cells is associated with reduction of type I cyclic AMP-dependent protein kinase and cyclic AMP response element-binding protein DNA-binding activities
    • Rohlff C, Safa B, Rahman A et al. Reversal of resistance to adriamycin by 8-chloro-cyclic AMP in adriamycin-resistant HL-60 leukaemia cells is associated with reduction of type I cyclic AMP-dependent protein kinase and cyclic AMP response element-binding protein DNA-binding activities. Mol Pharmacol 1993; 43: 372-9.
    • (1993) Mol Pharmacol , vol.43 , pp. 372-379
    • Rohlff, C.1    Safa, B.2    Rahman, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.