An ATP-ADP switch in MuB controls progression of the Mu transposition pathway

EMBO Journal

Volumn 17, Issue 18, 1998, Pages 5509-5518

  Yamauchi, Michael ^a   Baker, Tania A ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

ATP hydrolysis; ATP binding protein; DNA binding; Molecular switch; Protein DNA interaction

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; DNA BINDING PROTEIN; MUTANT PROTEIN; TRANSPOSASE;

ARTICLE; BINDING AFFINITY; CATALYSIS; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; BACTERIOPHAGE MU; DNA TRANSPOSABLE ELEMENTS; DNA, VIRAL; DNA-BINDING PROTEINS; HYDROLYSIS; MUTATION; RECOMBINATION, GENETIC; TRANSPOSASES; VIRAL PROTEINS;

EID: 0032530649     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.18.5509     Document Type: Article

References (55)

1. Adzuma, K. and Mizuuchi, K. (1988) Target immunity of Mu transposition reflects a differential distribution of Mu B protein. Cell, 53, 257-266.
2. Adzuma, K. and Mizuuchi, K. (1989) Interaction of proteins located at a distance along DNA: mechanism of target immunity in the Mu DNA strand-transfer reaction. Cell, 57, 41-47.
3. Adzuma, K. and Mizuuchi, K. (1991) Steady-state kinetic analysis of ATP hydrolysis by the B protein of bacteriophage Mu. J. Biol. Chem., 266, 6159-6167.
4. Andrake, M.B. and Skalka, A.M. (1996) Retroviral integrase, putting the pieces together. J. Biol. Chem., 271, 19633-19636.
5. Baker, T.A. and Mizuuchi, K. (1992) DNA-promoted assembly of the active tetramer of the Mu transposase. Genes Dev., 6, 2221-2232.
6. Baker, T.A., Mizuuchi, M. and Mizuuchi, K. (1991) MuB protein allosterically activates strand transfer by the transposase of phage Mu. Cell, 74, 723-733.
7. Baker, T.A., Mizuuchi, M., Savilahti, H. and Mizuuchi, K. (1993) Division of labor among monomers within the Mu transposase tetramer. Cell, 74, 723-733.
8. Baker, T.A., Krementsova, E. and Luo, L. (1994) Complete transposition requires four active monomers in the Mu transposase tetramer. Genes Dev., 8, 2416-2428.
9. Bourne, H.R., Sanders, D.A. and McCormick, F. (1991) The GTPase superfamily: conserved structure and molecular mechanism. Nature, 349, 117-127.
10. Blum, S., Schmid, S., Pause, A., Buser, P., Linder, P., Sonenberg, N. and Trachsel, H. (1992) ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA, 89, 7664-7668.
11. Cormack, B. (1997) Directed mutagenesis using the polymerase chain reaction. In Ausubel, F.A., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A. and Struhl, K. (eds). Current Protocols in Molecular Biology. John Wiley and Sons, New York, Vol. 1, pp. 8.5.1-8.5.10.
12. Craig, N.L. (1995) Unity in transposition reactions. Science, 270, 253-254.
13. Craig, N.L. (1996) V(D)J recombination and transposition: closer than expected. Science, 271, 1512.
14. Craig, N.L. (1997) Target site selection in transposition. Annu. Rev. Biochem., 66, 437-474.
15. Craigie, R. and Mizuuchi, K. (1985) Cloning of the A gene of bacteriophage Mu and purification of its product, the Mu transposase. J. Biol. Chem., 260, 1832-1835.
16. Craigie, R. and Mizuuchi, K. (1987) Transposition of Mu DNA: joining of Mu to target DNA can be uncoupled from cleavage at the ends of Mu. Cell, 51, 493-501.
17. Craigie, R., Arndt-Jovin, D.J. and Mizuuchi, K. (1985) A defined system for the DNA strand-transfer reaction at the initiation of bacteriophage Mu transposition: protein and DNA substrate requirements. Proc. Natl Acad. Sci. USA, 82, 7570-7574.
18. Darzins, A., Kent, N.E., Buckwalter, M.S. and Casadaban, M.J. (1988) Bacteriophage Mu sites required for transposition immunity. Proc. Natl Acad. Sci. USA, 85, 6826-6830.
19. Gradia, S., Acharya, S. and Fishel, R. (1997) The human mismatch recognition complex hMSH2-hMSH6 as a novel molecular switch. Cell, 91, 995-1005.
20. Jurnak, F. (1985) Structure of the GDP domain of EF-Tu and location of the amino acids homologous to ras oncogene proteins. Science, 230, 32-36.
21. Klemm, R.D., Austin, R.J. and Bell, S.P. (1997) Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex. Cell, 88, 493-502.
22. Kruklitis, R., Welty, D.J. and Nakai, H. (1996) ClpX protein of Escherichia coli activates bacteriophage Mu transposase in the strand transfer complex for initiation of Mu DNA synthesis. EMBO J., 15, 935-944.
23. Kunkel, T.A. (1985) Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl Acad. Sci. USA, 82, 488-492.
24. la Cour, T.F.M., Nyborg, J., Thirup, S. and Clark, B.F.C. (1985) Structural details of the binding of guanosine diphosphate to elongation factor Tu from E.coli as studied by X-ray crystallography. EMBO J., 4, 2385-2388.
25. Laurent, B.C., Treich, I. and Carlson, M. (1993) The yeast SNF2/SWI2 protein has DNA-stimulated ATPase activity required for transcriptional activation. Genes Dev., 7, 583-591.
26. Lavoie, B.D., Chan, B.S., Allison, R.G. and Chaconas, G. (1991) Structural aspects of a higher-order nucleoprotein complex: induction of an altered DNA structure at the Mu-host junction of the Mu Type 1 transpososome. EMBO J., 10, 3051-3059.
27. Leung, P.C. and Harshey, R.M. (1991) Two mutations of phage Mu transposase that affect strand transfer or interactions with B protein. J. Mol. Biol., 219, 189-199.
28. Levchenko, I., Luo, L. and Baker, T.A. (1995) Disassembly of the Mu transposase tetramer by the ClpX chaperone. Genes Dev., 9, 2399-2408.
29. Levchenko, I., Yamauchi, M. and Baker, T.A. (1997) ClpX and MuB interact with overlapping regions of Mu transposase: implications for control of the transposition pathway. Genes Dev., 11, 1561-1572.
30. Lim, W.A., Sauer, R.T. and Lander, A.D. (1991) Analysis of DNA-protein interactions by affinity coelectrophoresis. Mehtods Enzymol., 208, 196-210.
31. Maxwell, A., Craigie, R. and Mizuuchi, K. (1987) B protein of bacteriophage Mu is an ATPase that preferentially stimulates intermolecular DNA strand transfer. Proc. Natl Acad. Sci. USA, 84, 699-703.
32. Miller, J.L., Anderson, S.K., Fujita, D.J., Chaconas, G., Baldwin, D.L. and Harshey, R.M. (1984) The nucleotide sequence of the B gene of bacteriophage Mu. Nucleic Acids Res., 12, 8627-8638.
33. Millner, A. and Chaconas, G. (1998) Disruption of target DNA binding in Mu DNA transposition by alteration of position 99 in the Mu B protein. J. Mol. Biol., 275, 233-243.
34. Mizuuchi, K. (1992a) Polynucleotide transfer reactions in transpositional DNA recombination. J. Biol. Chem., 267, 21273-21276.
35. Mizuuchi, K. (1992b) Transpositional recombination: mechanistic insights from studies of Mu and other elements. Annu. Rev. Biochem., 61, 1011-1051.
36. Mizuuchi, M. and Mizuuchi, K. (1993) Target site selection in transposition of phage Mu. Cold Spring Harbor Symp. Quant. Biol., 58, 515-523.
37. Mizuuchi, M., Baker, T.A. and Mizuuchi, K. (1992) Assembly of the active form of the transposase-Mu DNA complex: a critical control point in Mu transposition. Cell, 70, 303-311.
38. Mizuuchi, M., Baker, T.A. and Mizuuchi, K. (1995) Assembly of phage Mu transpososomes: cooperative transitions assisted by protein and DNA scaffolds. Cell, 83, 375-385.
39. Müller, C.W. and Schulz, G.E. (1992) Structure of the complex between adenylate kinase from Escherichia coli and the inhibitor Ap5A refined at 1.9 Å resolution. J. Mol. Biol., 224, 159-177.
40. Naigamwalla, D.Z. and Chaconas, G. (1997) A new set of Mu DNA transposition intermediates: alternate pathways of target capture preceding strand transfer. EMBO J., 16, 5227-5234.
41. Nakai, H. and Kruklitis, R. (1995) Disassembly of the bacteriophage Mu transposase for the initiation of Mu DNA replication. J. Biol. Chem., 270, 19591-19598.
42. Pai, E.F., Krengel, U., Petsko, G.A., Goody, R.S., Kabsch, W. and Wittinghofer, A. (1990) Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 Å resolution: implications for the mechanism of GTP hydrolysis. EMBO J., 9, 2351-2359.
43. Pause, A. and Sonenberg, N. (1992) Mutational analysis of a DEAD box RNA helicase: the mammalian translation factor eIF-4A. EMBO J., 11, 2643-2654.
44. Pérez-Martín, J. and Lorenzo, V.D. (1996) ATP binding to the s54-dependent activator Xy1R triggers a protein multimerization cycle catalyzed by UAS DNA. Cell, 86, 331-339.
45. Reyes, O., Beyou, A., Mignotte-Vieux, C. and Richaud, F. (1987) Mini-Mu transduction: cis-inhibition of the insertion of Mud transposons. Plasmid, 18, 183-192.
46. Savilahti, H., Rice, P.A. and Mizuuchi, K. (1995) The phage Mu transpososome core: DNA requirements for assembly and function. EMBO J., 14, 4893-4903.
47. Story, R.M. and Steitz, T.A. (1992) Structure of the recA protein-ADP complex. Nature, 355, 374-376.
48. Surette, M.G. and Chaconas, G. (1991) Stimulation of the Mu DNA strand cleavage and intramolecular strand transfer reactions by the Mu B protein is independent of stable binding of the Mu B protein to DNA. J. Biol. Chem., 266, 17306-17313.
49. Surette, M.G., Bush, S.M. and Chaconas, G. (1987) Transpososomes: stable protein-DNA complexes involved in the in vitro transposition of bacteriophage Mu DNA. Cell, 49, 253-262.
50. Surette, M.G., Harkness, T. and Chaconas, G. (1991) Stimulation of the Mu A protein-mediated strand cleavage reaction by the Mu B protein and the requirement of DNA nicking for stable type I transpososome formation. J. Biol. Chem., 266, 3118-3124.
51. Teplow, D.B. and Harshey, R.M. (1988) Structure-function relationships in the transposition protein B of bacteriophage Mu. J. Biol. Chem., 263, 10851-10857.
52. van Gent, D.C., Mizuuchi, K. and Gellert, M. (1996) Similarities between initiation of V(D)J recombination and retroviral integration. Science 271, 1592-1594.
53. Walker, J.E., Saraste, M., Runswick, M.J. and Gay, N.J. (1982) Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J., 1, 945-951.
54. Watson, M.A. and Chaconas, G. (1996) Three-site synapsis during Mu DNA transposition: a critical intermediate preceding engagement of the active site. Cell, 85, 435-445.
55. Welty, D.J., Jones, J.M. and Nakai, H. (1997) Communication of ClpXP protease hypersensitivity to bacteriophage Mu repressor isoforms. J. Mol. Biol., 272, 31-41.