Metalloprotein design

Current Opinion in Biotechnology

Volumn 7, Issue 4, 1996, Pages 437-441

  Hellinga, Homme W ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL; METALLOPROTEIN;

AFFINITY CHROMATOGRAPHY; BIOSENSOR; CHELATION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTEIN STABILITY; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0030220211     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(96)80121-2     Document Type: Article

References (56)

1. Silva JJRFD, Williams RJP. The Biological Chemistry of the Elements. 1991;Clarendon Press, Oxford.
2. Bertini I, Gray HB, Lippard SJ, Valentine JS. Bioinorganic Chemistry. 1994;University Science Books, Sausalito.
3. Kaim W, Schewderski B. Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life. 1994;Wiley, New York.
4. Lippard SJ, Berg JM. Principles of Bioinorganic Chemistry. 1994;University Science Books, Mill Valley.
5. Tainer JA, Roberts VA, Getzoff ED. Protein metal-binding sites. Curr Opin Biotechnol. 3:1992;378-387.
6. Tainer JA, Roberts VA, Getzoff ED. Metal-binding sites in proteins. Curr Opin Biotechnol. 2:1991;582-591.
7. Hellinga HW. Design of metalloproteins. Cleland JL, Craik CS. Protein Engineering: Principles and Practice. 1996;369-398 Wiley-Liss, New York.
8. Regan L. The design of metal-binding sites in proteins. Annu Rev Biophys Biomol Struct. 22:1993;257-281.
9. Regan L. Protein design: novel metal-binding sites. Trends Biochem Sci. 20:1995;280-285.
10. Christianson DW. Structural biology of zinc. Adv Protein Chem. 42:1991;281-355.
11. Malmström BG. Rack-induced bonding in blue-copper proteins. Eur J Biochem. 223:1994;711-718.
12. Barbas CF, Rosenblum JS, Lerner RA. Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries. Proc Natl Acad Sci USA. 90:1993;6385-6389.
13. Todd RJ, Dam MEV, Casimiro D, Haymore BL, Arnold FH. Cu(II)-binding properties of a cytochrome c with a synthetic metal-binding site: His - X3 - His in an alpha-helix. Proteins. 10:1991;156-161.
14. Roberts VA, Iverson BL, Iverson SA, Benkovic SJ, Lerner RA, Getzoff ED, Tainer JA. Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket. Proc Natl Acad Sci USA. 87:1990;6654-6658.
15. Clarke ND, Yuan S-M. Metal search: a computer program that helps design tetrahedral metal-binding sites. Proteins. 23:1995;256-263.
16. Hellinga HW, Richards HW. Construction of new ligand binding sites in proteins of known structure. I. Computer-aided modeling of sites with pre-defined geometry. J Mol Biol. 222:1991;763-785.
17. McPhalen CA, Strynadka NCJ, James NCJ. Calcium-binding sites in proteins: a structural perspective. Adv Protein Chem. 42:1991;77-144.
18. 2+ binding site in human lysozyme to enhance structural stability. Proc Natl Acad Sci USA. 86:1989;6903-6907.
19. 2+-binding site into human lysozyme. Protein Eng. 6:1993;643-649.
20. 2+ binding site. J Biol Chem. 266:1991;20666-20671.
21. Kuroki R, Kawakita S, Nakamura H, Yutani K. Entropic stabilization of a mutant human lysozyme induced by calcium binding. Proc Natl Acad Sci USA. 89:1992;6803-6807.
22. Toma S, Campagnoli S, Margarit I, Gianna R, Grandi G, Bolognesi M, Filippis VD, Fontana A. Grafting of a calcium-binding loop of thermolysin to Bacillus subtilis neutral protease. Biochemistry. 30:1991;97-106.
23. 2+-binding loop into subtilisin BPN'. Biochemistry. 31:1992;7796-7801.
24. Arnold FH, Haymore BL. Engineered metal-binding proteins: purification to protein folding. Science. 252:1991;1796-1798.
25. Suh SS, Haymore BL, Arnold FH. Characterization of His - X3 - His sites in alpha-helices of synthetic metal-binding bovine somatotropin. Protein Eng. 4:1991;301-309.
26. Muheim A, Todd RJ, Casimiro DR, Gray HB, Arnold FH. Ruthenium-mediated protein cross-linking and stabilization. J Am Chem Soc. 115:1993;5312-5313.
27. Müller HN, Skerra A. Grafting of a high-affinity Zn(II)-binding site on the β-barrel of retinol-binding protein results in enhanced folding stability and enables simplified purification. Biochemistry. 33:1994;14126-14135.
28. Hochuli E, Bannwarth W, Döbeli H, Gentz R, Stuber D. Genetic approach to facilitate purification of recombinant proteins with a novel metal chelate adsorbent. Bio-technology. 6:1988;1321-1325.
29. 2+-binding protein. J Am Chem Soc. 112:1990;6710-6712.
30. Handel TM, Williams SA, DeGrado WF. Metal ion-dependent modulation of the dynamics of a designed protein. Science. 261:1993;879-885.
31. Regan L, Clarke ND. A tetrahedral zinc(II)-binding site introduced into a designed protein. Biochemistry. 29:1990;10878-10883.
32. Higaki JN, Haymore BL, Chen S, Fletterick RJ, Craik CS. Regulation of serine protease activity by an engineered metal switch. Biochemistry. 29:1990;8582-8586.
33. McGrath ME, Haymore BL, Summers NL, Craik CS, Fletterick RJ. Structure of an engineered, metal-actuated switch in trypsin. Biochemistry. 32:1993;1914-1919.
34. Willett WS, Gillmor SA, Perona JJ, Fletterick RJ, Craik CS. Engineered metal regulation of trypsin specificity. of outstanding interest Biochemistry. 34:1995;2172-2180 A shared coordination sphere was created between trypsin and a peptide substrate. This paper demonstrates how clever exploitation of coordination geometry can be utilized to introduce novel control mechanisms.
35. Browner MF, Hackos D, Fletterick RJ. Identification of the molecular trigger for allosteric activation in glycogen phosphorylase. Nat Struct Biol. 1:1994;327-333.
36. Czarnik AW. Desperately seeking sensors. Chem Biol. 2:1995;423-428.
37. Tsien RY. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structure. Biochemistry. 19:1980;2396-2404.
38. 2+. J Am Chem Soc. 116:1994;415-416.
39. Thompson RB, Jones ER. Enzyme-based fiber optic zinc sensor. Anal Chem. 65:1993;730-734.
40. Ippolito JA, Baird TT, McGee SA, Christianson DW, Fierke CA. Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity. Proc Natl Acad Sci USA. 92:1995;5017-5021.
41. Huang C, Lesburg CA, Kiefer LL, Fierke CA, Christianson DW. Reversal of hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry. 35:1996;3439-3446.
42. Bryson JW, Betz SF, Lu HS, Suich DJ, Zhou HX, O'Neil KT, DeGrado WF. Protein design: a hierarchic approach. Science. 270:1995;935-941.
43. Ibers JA, Holm RH. Modeling of coordination sites in metallobiomolecules. Science. 209:1980;223-235.
44. Berg JM, Shi Y. The galvanization of biology: a growing appreciation for the roles of zinc. Science. 271:1996;1081-1085.
45. 2 site. of special interest Biochemistry. 34:1995;10094-10100 A careful combined mutagenesis and spectroscopic study to prove that the actual coordination geometry matched the original design.
46. 3Cys site in the B1 domain of protein G. This design is the first phase in a carefully crafted design plan to construct catalytic centers.
47. Kitajima N. Synthetic approach to the structure and function of copper proteins. Adv Inorg Chem. 39:1992;1-77.
48. Hellinga HW, Caradonna JP, Richards FM. Construction of new ligand binding sites in proteins of known structure. II. Grafting of a buried transition metal binding site into Escherichia coli thioredoxin. J Mol Biol. 222:1991;787-803.
49. Toma CT, Lear JD, Nelson MJ, Dutton PL, Robertson DE, DeGrado WF. Design of a heme-binding four-helix bundle. J Am Chem Soc. 116:1994;856-865.
50. Robertson DE, Farid RS, Moser CC, Urbauer JL, Mulholland SE, Pidikiti JD, Lear JD, Wand AJ, DeGrado WF, Dutton PL. Design and synthesis of multi-haem proteins. Nature. 368:1994;425-431.
51. Roberts VA, Getzoff ED. Metalloantibody design. of special interest FASEB J. 9:1995;94-100 A thorough exposition of the principles employed to construct open coordination sites in antibody frameworks with the eventual aim of constructing a catalytic center.
52. Crowder MW, Stewart JD, Roberts VA, Bender CJ, Tevelrakh E, Peisach J, Getzoff ED, Gaffney BJ, Benkovic SJ. Spectroscopic studies on the designed metal-binding sites of the 43C9 single chain antibody. J Am Chem Soc. 117:1995;5627-5634.
53. Iverson BL, Lerner RA. Sequence-specific peptide cleavage catalyzed by an antibody. Science. 243:1989;1184-1188.
54. Iverson BL, Iverson SA, Roberts VA, Getzoff ED, Tainer JA, Benkovic SJ, Lerner RA. Metalloantibodies. Science. 249:1990;659-662.
55. Wade WS, Ashley JA, Jahangiri GK, McElhaney G, Janda KD, Lerner RA. A highly specific metal-activated catalytic antibody. J Am Chem Soc. 115:1993;4906-4907.
56. Wade WS, Koh JS, Han N, Hoekstra DM, Lerner RA. Engineering metal coordination sites into the antibody light chain. J Am Chem Soc. 115:1993;4449-4456.