Understanding mammary gland development through the imbalanced expression of growth regulators

Developmental Dynamics

Volumn 206, Issue 2, 1996, Pages 159-168

  Robinson, Gertraud W ^a   Smith, Gilbert H ^b   Gallahan, Daniel ^b   Zimmer, Andreas ^c   Furth, Priscilla A ^d   Hennighausen, Lothar ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Alveolar differentiation; Mammary development; Transgenes

Indexed keywords

ACID PROTEIN; CELL PROTEIN; MILK PROTEIN; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VIRUS T ANTIGEN; WHEY ACID PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST DEVELOPMENT; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GROWTH REGULATION; LACTATION DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIMIAN VIRUS 40; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; CELL DIFFERENTIATION; FEMALE; GENE EXPRESSION REGULATION; GROWTH SUBSTANCES; LACTATION; MAMMARY GLANDS, ANIMAL; MICE; MICE, TRANSGENIC; MILK PROTEINS; PREGNANCY; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH; RETINOBLASTOMA PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TRANSGENES; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MUS MUSCULUS; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40;

EID: 0029953661     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0177(199606)206:2<159::AID-AJA5>3.0.CO;2-H     Document Type: Article

References (32)

1. Andres, A.-C., Schonenberger, C.-A., Groner, B., Hennighausen, L., LeMeur, M., and Gerlinger, P. (1987) Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice. Proc. Natl. Sci. U.S.A. 84:1299-1303.
2. Burdon, T., Wall, R.J., Shamay, A., Smith, G.H., and Hennighausen, L. (1991a) Over-expression of an endogenous milk protein gene in transgenic mice is associated with impaired mammary alveolar development and a milchlos phenotype. Mech. Dev. 36:67-74.
3. Burdon, T., Sankaran, L., Wall, R.J., Spencer, M., and Hennighausen, L. (1991b) Expression of a whey acidic protein transgene during mammary development: evidence for different mechanisms of regulation during pregnancy and lactation. J. Biol. Chem. 266:6909-6914.
4. Chomczynski, P., and Sacchi, N. (1987) Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
5. Conlon, R.A., Reaume, A.G., and Rossant, J. (1995) Notch1 is required for the coordinate segmentation of somites. Development 121:1533-1545.
6. Datto, M.B., Li, Y., Panus, J.F., Howe, D.J., Xiong, Y., and Wang, X.-F. (1995) Transforming growth factor β induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. U.S.A. 92:5545-5549.
7. Franch, H.A., Shay, J.W., Alpern, R.J., and Preisig, P.A. (1995) Involvement of pRB family in TGFβ-dependent epithelial cell hypertrophy. J. Cell Biol. 129:245-254.
8. Hennighausen, L., McKnight, R.A., Burdon, T., Baik, M., Wall, R.J., and Smith, G.H. (1994) Whey acidic protein extrinsically expressed from the mouse mammary tumor virus long terminal repeat results in hyperplasia of the coagulation gland epithelium and impaired mammary development. Cell Growth Differ. 5:607-613.
9. Jhappan, C., Stahle, C., Fausto, R.N., Smith, G.H., and Merlino, G.T. (1990) TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell 61:1137-1146.
10. Jhappan, C., Gallahan, D., Stahle, C., Chu, E., Smith, G.H., Merlino, G., and Callahan, R. (1992) Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev. 6:345-355.
11. Jhappan, C., Geiser, A.G., Kordon, E.C., Bagheri, D., Hennighausen, L., Roberts, A.B., Smith, G.H., and Merlino, G. (1993) Targeting expression of a transforming growth factor β1 transgene to the pregnant mammary gland inhibits alveolar development and lactation. EMBO J. 12:1835-1845.
12. Koff, A., Ohtsuki, M., Polyak, K., Roberts, J.M., and Massague, J. (1993) Negative regulation of G1 in mammalian cells: Inhibition of cyclin E-dependent kinase by TGF-β. Science 260:536-539.
13. Kordon, E.C., McKnight, R.A., Jhappan, C., Hennighausen, L., Merlino, G., and Smith G.H. (1995) Ectopic TGFβ1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population. Dev. Biol. 167:47-61.
14. Laiho, M., DeCaprio, J.A., Ludlow, J.W., Livingston, D.M., and Massague, J. (1990) Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation. Cell 62:175-185.
15. Li, M.L., Hu, J.D., Heermeier, K., Hennighausen, L., and Furth P.A. (1996) Expression of a viral oncoprotein during mammary-gland development alters cell fate and function: Induction of p53-independent apoptosis is followed by impaired milk protein-production in surviving cells. Cell Growth Differ. 7:3-11.
16. Lin, C.Q., Dempsey, P.J., Coffey, R.J., and Bissell, M.J. (1995) Extracellular matrix regulates whey acidic protein gene expression by suppression of TGF-α in mouse mammary epithelial cells: Studies in culture and in transgenic mice. J. Cell Biol. 129:1115-1126.
17. Matsui, Y., Halter, S.A., Holt, J.T., Hogan, B.L.M., and Coffey, R.J. (1990) Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice. Cell 61:1147-1155.
18. Pierce, D.F., Jr., Johnson, M.D., Matsui, Y., Robinson, S.D., Gold, L.I., Purchio, A.F., Daniel, C.W., Hogan, B.L.M., and Moses, H.L. (1993) Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-β1. Genes Dev. 7:2308-2317.
19. Pittius, C.W., Sankaran, S., Topper, Y., and Hennighausen, L. (1988) Comparison of the regulation of the whey acidic protein gene to a hybrid gene containing the whey acidic protein gene promoter in transgenic mice. Mol. Endocrinol. 2:1027-1032.
20. Robbins, J., Blondel, B.J., Gallahan, D., and Callahan, R. (1992) Mouse mammary tumor gene INT3: a member of the Notch gene family transforms mammary epithelial cells. J. Virol. 66:2594-2599.
21. Robinson, S.D., Silberstein, G.B., Roberts, A.B., Flanders, K.C., and Daniel, C.W. (1991) Regulated expression and growth inhibitory effects of transforming growth factor β isoforms in mouse mammary gland development. Development 113:867-878.
22. Robinson, G.W., McKnight, R.A., Smith, G.H., and Hennighausen, L. (1995) Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation. Development 121:2079-2090.
23. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) "Molecular Cloning. A Laboratory Handbook." Cold Spring Harbor, NY: Cold Spring Harbor Press.
24. Sandgren, E.P., Luetteke, N.C., Palmiter, R.D., Brinster, R.L., and Lee, D.C. (1990) Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell 61:1121-1135.
25. Sandgren, E., Schroeder, J.A., Qui, T.H., Palmiter, R.D., Brinster, R.L., and Lee, D.C. (1995) Inhibition of mammary gland involution is associated with TGFα- but not c-nyc-induced tumorigenesis in transgenic mice. Cancer Res. 55:3915-3927.
26. Schoenenberger, C.-A., Zuk, A., Groner, B., Jones, W., Andres, A.-C. (1990) Induction of the endogenous whey acidic protein (WAP) gene and a WAP-myc hybrid gene in primary murine mammary organoids. Dev. Biol. 139:327-337.
27. Silberstein, G.B., Flanders, K.C., Roberts, A.B., and Daniel, C.W. (1992) Regulation of mammary morphogenesis: evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-β1. Dev. Biol. 152:354-362.
28. Simpson, P. (1995). The Notch connection. Nature 375:736-737.
29. Smith, G.H., Gallahan, D., Diella, F., Jhappan, C., Merlino, G., and Callahan, R. (1995a) Constitutive expression of a truncated 1NT3 gene in mouse mammary epithelium impairs differentiation and functional development. Cell Growth Differ. 6:563-577.
30. Smith, G.D., Sharp, R., Kordon, E.C., Jhappan, C., and Merlino, G. (1995b) Transforming growth factora promotes mammary tumorigenesis through selective survival and growth of secretory epithelial cells. Am. J. Pathol. 147:1081-1096.
31. Snedeker, S.M., Brown, C.F., and DiAugustine, R.P. (1991) Expression and functional properties of transforming growth factor α and epidermal growth factor during mouse mammary gland ductal morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 88:276-280.
32. Tzeng, Y.-J., Guhl, E., Graessmann, M., and Graessmann, A. (1993) Breast cancer formation in transgenic animals induced by the whey acidic protein SV40 T antigen (WAP-SV-T) hybrid gene. Oncogene 8:1965-1971.