Effects of glucose deprivation, chemical hypoxia, and simulated ischemia on Na+ homeostasis in rat spinal cord astrocytes

Journal of Neuroscience

Volumn 18, Issue 10, 1998, Pages 3554-3562

  Rose, Christine R ^a,b,d   Waxman, Stephen G ^a,b   Ransom, Bruce R ^c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d SAARLAND UNIVERSITY   (Germany)

Author keywords

Anoxia; Excitotoxicity; Glia; Hypoglycemia; Kainate; Na+ K+ ATPase; Sodium binding benzofuran isophthalate

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BENZOFURAN DERIVATIVE; CALCIUM ION; GLUCOSE; ISOPHTHALIC ACID; KAINIC ACID; POTASSIUM ION; SODIUM ION;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; ASTROCYTE; CELL PH; CONTROLLED STUDY; GLIA CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM BALANCE; SODIUM CURRENT; SPINAL CORD ISCHEMIA; SPINAL CORD NERVE CELL;

EID: 0032525075     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-10-03554.1998     Document Type: Article

References (64)

1. 2+ exchanger. J Neurosci 16:545-552.
2. + transport. J Neurosci 12:840-853.
3. Auer RN, Siesjö BK (1988) Biological differences between ischemia, hypoglycemia, and epilepsy. Ann Neurol 24:699-707.
4. Billups B, Attwell D (1996) Modulation of non-vesicular glutamate release by pH. Nature 379:171-174.
5. Black JA, Sontheimer H, Waxman SG (1993) Spinal cord astrocytes in vitro; phenotypic diversity and sodium channel immunoreactivity. Glia 7:272-285.
6. Choi DW, Rothman SM (1990) The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci 13:171-182.
7. David JC, Yamada KA, Bagwe MR, Goldberg MP (1996) AMPA receptor activation is rapidly toxic to cortical astrocytes when desensitization is blocked. J Neurosci 16:200-209.
8. Duffy S, MacVicar BA (1996) In vitro ischemia promotes calcium influx and intracellular calcium release in hippocampal astrocytes. J Neurosci 16:71-81.
9. Erecinska M, Silver IA (1994) Ions and energy in mammalian brain. Prog Neurobiol 43:37-71.
10. Friedman JE, Haddad GG (1994) Anoxia induces an increase in intracellular sodium in rat central neurons in vitro. Brain Res 663:329-334.
11. Gemba T, Oshima T, Nimomiya M (1994) Glutamate efflux via the reversal of the sodium-dependent glutamate transporter caused by glycolytic inhibition in rat cultured astrocytes. Neuroscience 63:789-795.
12. Goldberg MP, Choi DW (1993) Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury. J Neurosci 13:3510-3524.
13. Goldman WF, Yarowsky PJ, Juhaszova M, Krueger BK, Blaustein MP (1994) Sodium/calcium exchange in rat cortical astrocytes. J Neurosci 14:5834-5843.
14. Gregory GA, Welsh FA, Yu ACH, Chan PH (1990) Fructose-1,6-bisphosphate reduces ATP loss from hypoxic astrocytes. Brain Res 516:310-312.
15. Hamprecht B, Dringen R (1995) Energy metabolism. In: Neuroglia (Kettenmann H, Ransom BR, eds), pp 473-487. New York: Oxford UP.
16. Hansen AJ (1985) Effect of anoxia on ion distribution in the brain. Physiol Rev 65:101-148.
17. Hori O, Matsumoto M, Maeda Y, Ueda H, Ohtsuki T, Stern DM, Kinoshita T, Ogawa S, Kamuda T (1994) Metabolic and biosynthetic alterations in cultured astrocytes exposed to hypoxia/reoxygenation. J Neurochem 62:1489-1495.
18. Imuizumi T, Kocsis JD, Waxman SG (1997) Anoxic injury in rat spinal cord: pharmacological evidence for multiple steps in Ca-dependent injury of the dorsal columns. J Neurotrauma 14:299-313.
19. Kauppincn RA, Enkvist K, Holopainen I, Akerman KEO (1988) Glucose deprivation depolarizes plasma membrane of cultured astrocytes and collapses transmembrane potassium and glutamate gradients. Neuroscicnce 26:283-284.
20. Kelleher SA, Chan PN, Chan TY, Gregory GA (1993) Modification of hypoxia-induced injury in cultured rat astroeytes by high levels of glucose. Stroke 24:855-863.
21. Kiedrowski L, Brooker G, Costa E, Wroblewski JT (1994) Glutamate impairs neuronal calcium extrusion while reducing sodium gradient. Neuron 12:295-300.
22. Kim-Lee MH, Stokes BT, Yates AJ (1992) Reperfusion paradox: a novel mode of glial cell injury. Glia 5:56-64.
23. Kimelberg HK, Ransom BR (1986) Physiological and pathological aspects of astrocytic swelling. In: Astrocytes (Federoff S, Vernadakis A, eds). pp 129-166. Orlando, FL: Academic.
24. + in primary astrocyte cultures. J Neurosci 9:1141-1149.
25. Koch RA, Barish ME (1994) Perturbation of intracellular calcium and hydrogen ion regulation in cultured mouse hippocampal neurons by reduction of the sodium ion concentration gradient. J Neurosci 14:2585-2593.
26. Kraig RP, Chester M (1990) Astrocytic acidosis in hyperglycemic and complete ischemia. J Cereb Blood Flow Metab 10:104-114.
27. Kraig RP, Lascola CD, Caggiano A (1995) Glial response to brain ischemia. In: Neuroglia (Kettenmann H, Ransom BR, eds), pp 964-976. New York: Oxford UP.
28. Lees GJ (1991) Inhibition of sodium-potassium-ATPase: a potentially ubiquitous mechanism contributing to central nervous system neuropathology. Brain Res Rev 16:283-300.
29. Lehning EJ, Doshi R, Stys PK, LoPachin RM (1995) Mechanisms of injury-induced calcium entry into peripheral nerve myelinaled axons: in vitro anoxia and ouabain exposure. Brain Res 694:158-166.
30. Lehning EJ, Doshi R, Isaksson N, Stys PK, LoPachin RM (1996) Mechanisms of injury-induced calcium entry into peripheral nerve myelinated axons: role of reverse sodium-calcium exchange. J Neurochem 66:493-500.
31. + uptake require glycolysis. Fed Proc 42:2875-2880.
32. Longuemare MC, Hill MP, Swanson RA (1994) Glycolysis can prevent non-synaptic excitatory amino acid release during hypoxia. NeuroReport 5:1789-1792.
33. LoPachin RM, Stys PK (1995) Elemental composition and water content of rat optic nerve myelinated axons and glial cells: effects of in vitro anoxia and reoxygenation. J Neurosci 15:6735-6746.
34. Lucas JH, Emery DG, Rosenberg LJ (1997) Physical injury of neurons: important roles for sodium and chloride ions. The Neuroscientist 3:89-101.
35. Lynch III JJ, Yu SP, Canzoniero LM, Sensi SL, Choi DW (1995) Sodium channel blockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists. J Pharmacol Exp Ther 273:554-560.
36. +] in rat astrocytes. Glia 16:7-15.
37. Pauwels PJ, Opperdoes FR, Trouet A (1985) Effects of antimycin, glucose deprivation, and serum on cultures of neurons, astrocytes, and neuroblastoma cells. J Neurochem 44:143-148.
38. Raffin CN, Sick TJ, Rosenthal M (1988) Inhibition of glycolysis alters potassium ion transport and mitochondrial redox activity in rat brain. J Cereb Blood Flow Metab 8:857-865.
39. Ransom BR (1991) Vertebrate glial classification, lineage, and heterogeneity. In: Glial-neuronal interactions (Abott NJ, ed), pp 19-26. New York: Ann NY Acad Sci.
40. Ransom BR, Fern R (1996) Anoxic-ischemic glial cells injury: mechanisms and consequences. In: Tissue oxygen deprivation (Haddad GG, Lister G, eds), pp 617-652. New York: Dekker.
41. + and pH in mammalian central white matter. J Cereb Blood Flow Metab 12:593-602.
42. + homeostasis in cultured rat hippocampal astrocytes. J Physiol (Lond) 491:291-305.
43. + changes induced by glutamate, kainate, and D-aspartate in rat hippocampal astrocytes. J Neurosci 16:5393-5404.
44. + channels in spinal cord astrocytes. J Neurophysiol 87:3249-3258.
45. Rosenberg PA (1991) Accumulation of extracellular glutamate and neuronal death in astrocyte-poor cultures exposed to glutamine. Glia 4:91-100.
46. Shimada N, Graf R, Rosner G, Heiss WD (1993) Ischemia-induced accumulation of extracellular amino acids in cerebral cortex, while matter, and cerebrospinal fluid. J Neurochem 60:66-71.
47. Siesjö BK (1985) Membrane events leading to glial swelling and brain edema. In: Brain edema (Inaba Y, ed), pp 200-209. Berlin: Springer.
48. + AT-Pase in mammalian astrocytes. Glia 21:35-45.
49. Silver IA, Deas J, Erecinska M (1997) Ion homeostasis in brain cells: differences in intraccllular ion responses to energy limitation between cultured neurons and glial cells. Neuroscience 78:589-601.
50. 14C] deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28:897-916.
51. Sontheimer H, Black JA, Ransom BR, Waxman SG (1992) Ion channels in spinal cord astrocytes in vitro. I. Transient expression of high levels of Na+ and K+ channels. J Neurophysiol 68:985-1000.
52. 2+ exchanger. J Neurosci 12:430-439.
53. Swanson RA (1992) Astrocyte glutamate uptake during chemical hypoxia in vitro. Neurosci Lett 147:143-146.
54. Swanson RA, Choi DW (1993) Glial glycogen stores affect neuronal survival during glucose deprivation in vitro. J Cereb Blood Flow Metab 13:162-169.
55. Sykova E, Svoboda J, Polak J, Chvatal A (1994) Extracellular volume fraction and diffusion characteristics during progressive ischemia and terminal anoxia in the spinal cord of the rat. J Cereb Blood Flow Metab 14:301-311.
56. Tator CH, Fehlings MG (1991) Review of the secondary theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 75:15-26.
57. Tsacopoulos M, Magistretti PJ (1996) Metabolic coupling between glia and neurons. J Neurosci 16:877-885.
58. Vibulsreth S, Hefti F, Ginsberg MD, Dietrich WD, Busto R (1987) Astrocytes protect cultured neurons from degeneration induced by anoxia. Brain Res 422:330-311.
59. Walz W, Hertz L (1982) Ouabain-sensitive and ouabain-resistant uptake of potassium into astrocytes and neurons in primary culture. J Neurochem 39:70-77.
60. Walz W, Hertz L (1983) Intracellular ion changes of astrocytes in response to extracellular potassium. J Neurosci Res 10:411-423.
61. Walz W, Mukerji S (1988) Lactate production and release in cultured astrocytes. Neurosci Lett 86:296-300.
62. Walz W, Klimaszewski A, Paterson IA (1993) Glial swelling in ischemia: a hypothesis. Dev Neurosci 15:216-225.
63. 2+-mediated injury in CNS white matter. Trends Neurosci 14:461-468.
64. Wiesinger B, Hamprecht B, Dringen R (1997) Metabolic pathways for glucose in astrocytes. Glia 21:22-34.