Nicotinic agonists competitively antagonize serotonin at mouse 5-HT3 receptors expressed in Xenopus oocytes

Neuroscience Letters

Volumn 247, Issue 2-3, 1998, Pages 107-110

  Gurley, David A ^a   Lanthorn, Thomas H ^a  

^a Astra Arcus USA   (United States)

Author keywords

5 HT3 receptors; Nicotinic receptors; Receptor superfamilies; Xenopus oocytes

Indexed keywords

1,1 DIMETHYL 4 PHENYLPIPERAZINIUM; 3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; ACETYLCHOLINE; ANATOXIN A; CHOLINE; EPIBATIDINE; NICOTINE; NICOTINIC AGENT; SEROTONIN; SEROTONIN 3 RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG COMPETITION; DRUG POTENCY; DRUG RECEPTOR BINDING; MOUSE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS LAEVIS;

ACETYLCHOLINE; ANIMALS; BACTERIAL TOXINS; BENZYLIDENE COMPOUNDS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; BINDING, COMPETITIVE; CHOLINE; DIMETHYLPHENYLPIPERAZINIUM IODIDE; DNA, COMPLEMENTARY; FEMALE; MARINE TOXINS; MICE; MICROCYSTINS; MULTIGENE FAMILY; NICOTINE; NICOTINIC AGONISTS; OOCYTES; PATCH-CLAMP TECHNIQUES; PYRIDINES; RECEPTORS, NICOTINIC; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; RECOMBINANT FUSION PROTEINS; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 0032524624     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00306-1     Document Type: Article

References (24)

1. Akasu T., Tokimasa T. Modulation of the sensitivity of nicotinic receptors in autonomic ganglia. Experientia. 57(Suppl.):1989;190-196.
2. Amar M., Thomas P., Johnson C., Lunt G.G., Wonnacott S. Agonist pharmacology of the neuronal α7 nicotinic receptor expressed in Xenopus oocytes. FEBS Lett. 327:1993;284-288.
3. Boess F.G., Steward L.J., Steele J.A., Liu D., Reid J., Glencorse T.A., Martin I.L. Analysis of the ligand binding site of the 5-HT3 receptor using site directed mutagenesis: importance of glutamate 106. Neuropharmacology. 36:1997;637-647.
4. Briggs C.A., McKenna D.G., Piattoni-Kaplan M. Human α7 nicotinic acetylcholine receptor responses to novel ligands. Neuropharmacology. 34:1995;583-590.
5. Changeux J.-P., Galzi J.-L., Devilliers-Thiery A., Bertrand D. The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis. Q. Rev. Biophys. 25:1992;395-432.
6. Cohen J.B., Sharp S.D., Liu W.S. Structure of the agonist-binding site of the nicotinic acetylcholine receptor. J. Biol. Chem. 266:1991;23354-23364.
7. Corringer P.-J., Galzi J.-L., Eisele J.-L., Bertrand S., Changeux J.-P., Bertrand D. Identification of a new component of the agonist binding site of the nicotinic ACh α7 homooligomer receptor. J. Biol. Chem. 270:1995;11749-11752.
8. Cross K.M.L., Foreman R.C., Chad J.E. Enhancement by 5-hydroxytryptamine and analogues of desensitization of neuronal and muscle nicotinic receptors expressed in Xenopus oocytes. Br. J. Pharmacol. 114:1995;1636-1640.
9. 125I-α-bungarotoxin receptor subtypes. Mol. Pharmacol. 47:1995;164-171.
10. Eisele J.-L., Bertrand S., Galzi J.-L., Devillers-Thiery A., Changeux J.-P., Bertrand D. Chimeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities. Nature. 366:1993;479-483.
11. Karlin A., Akabas M.H. Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins. Neuron. 15:1995;1231-1244.
12. 3 receptor, a serotonin-gated ion channel. Science. 154:1991;432-437.
13. Palma E., Mileo A.M., Eusebi F., Miledi R. Threonine-for leucine mutation within domain M2 of the neuronal α7 nicotinic receptor converts 5-hydroxytryptamine from antagonist to agonist. Proc. Natl. Acad. Sci. USA. 93:1996;11231-11235.
14. Palma E., Maggi L., Eusebi F., Miledi R. Neuronal nicotinic threonine-for leucine 247 α7 mutant receptors show different gating kinetics when activated by acetylcholine or by the noncompetitive agonist 5-hydroxytryptamine. Proc. Natl. Acad. Sci. USA. 94:1997;9915-9919.
15. Papke R.L., Bencherif M., Lippiello P. An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha-7 subtype. Neurosci. Lett. 213:1996;201-204.
16. Peng X., Katz M., Gerzanich V., Anand R., Lindstrom J. Human α7 acetylcholine receptor: cloning of the α7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional α7 homomers expressed in Xenopus oocytes. Mol. Pharmacol. 45:1994;546-554.
17. Séguéla P., Wadiche J., Dineley-Miller K., Dani J.A., Patrick J.W. Molecular cloning, functional properties, and distribution of rat brain α7: a nicotinic cation channel highly permeable to calcium. J. Neurosci. 13:1993;596-604.
18. Sepulveda M.-I., Baker J., Lummis S.C.R. Chlorpromazine and QX-222 block 5HT3 receptors in N1E-115 neuroblastoma cells. Neuropharmacology. 33:1994;493-499.
19. Werner P., Kawashima E., Reid J., Hussy N., Lundstrom K., Buell G., Humbert Y., Jones K.A. Organization of the mouse 5-HT3 receptor gene and functional expression of two splice variants. Mol. Brain Res. 26:1994;233-241.
20. 3 receptors mediate rapid responses in cultured hippocampus and a clonal cell line. Neuron. 1:1988;615-621.
21. Yakel J.L., Lagrutta A., Adelman J.P., North R.A. Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes. Proc. Natl. Acad. Sci. USA. 90:1993;5030-5033.
22. 3 receptor channels in dissociated rat superior cervical ganglion neurons. J. Physiol. 448:1992;237-256.
23. Yu D., Zhang L., Eisele J.L., Bertrand D., Changeux J.P., Weight F.F. Ethanol inhibition of nicotinic acetylcholine type alpha 7 receptors involves the amino-terminal domain of the receptor. Mol. Pharmacol. 50:1996;1010-1016.
24. 3 receptors expressed in Xenopus oocytes. Br. J. Pharmacol. 120:1997;353-355.