T:T antigen presentation by activated murine CD8+ T cells induces anergy and apoptosis

Journal of Immunology

Volumn 160, Issue 8, 1998, Pages 3655-3665

  Chai, Jian Guo ^a   Bartok, Istvan ^b   Scott, Diane ^b   Dyson, Julian ^b   Lechler, Robert ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b MRC CLINICAL SCIENCES CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD8 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS ANTIGEN; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; CELL INTERACTION; CELL PROLIFERATION; CELL SURVIVAL; CLONAL ANERGY; CONTROLLED STUDY; FEMALE; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; ANTIGENS, CD95; ANTIGENS, DIFFERENTIATION; APOPTOSIS; CD8-POSITIVE T-LYMPHOCYTES; CLONAL ANERGY; CLONE CELLS; FEMALE; H-Y ANTIGEN; IMMUNOCONJUGATES; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED CBA; RECEPTORS, TUMOR NECROSIS FACTOR;

EID: 0032522625     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Johnson, J. G., and M. K. Jenkins. 1994. The role of anergy in peripheral T cell unresponsiveness. Life Sci. 55:1767.
2. Schwartz, R. H. 1996. Models of T cell anergy: is there a common molecular mechanism? J. Exp. Med. 184:1.
3. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signalling costimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
4. Schwartz, R. H. 1992. Costimulation of T lymphocytes: the role of CD28, CTLA-4 and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71: 1065.
5. Linsley, P. S., W. Brady, L. Grosmaire, A. Aruffo, N. K. Damle, and J. A. Ledbetter. 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin-2 mRNA accumulation. J. Exp. Med. 173:721.
6. Freeman, G. J., J. G. Gribben, V. A. Boussiotis, J. W. Ng, V. A. J. Restivo, L. A. Lombard, G. S. Gray, and L. M. Nadler. 1993. Cloning B7-2: a CTLA-4 counter receptor that co-stimulates human T cell proliferation. Science 262: 909.
7. Jenkins, M. K., and R. H. Schwartz. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and vivo. J. Exp. Med. 165:302.
8. Quill, H., and R. H. Schwartz. 1987. Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness. J. Immunol. 138:3704.
9. Jenkins, M. K., C. Chen, G. Jung, D. L. Mueller, and R. H. Schwartz. 1990. Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody. J. Immunol. 144: 16.
10. Gimmi, C. D., G. J. Freeman, J. G. Gribben, G. Gray, and L. M. Nadler. 1993. Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc. Natl. Acad. Sci. USA 90:6586.
11. Boussiotis, V. A., G. J. Freeman, G. Gray, J. Gribben, and L. M. Nadler. 1993. B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance. J. Exp. Med. 178:1753.
12. Van Gool, S. W., M. de Boer, and J. L. Ceuppens. 1994. The combination of anti-B7 monoclonal antibody and cyclosporin A induces alloantigen-specific anergy during a primary mixed lymphocyte reaction. J. Exp. Med. 179:715.
13. Chen, C., and N. Nabavi. 1994. In vitro induction of T cell anergy by blocking B7 and early T cell costimulatory molecule ETC-1/B7-2. Immunity 1:147.
14. Tan, P., C. Anasetti, J. A. Hansen, J. Melrose, M. Brunvand, J. Bradshaw, J. A. Ledbetter, and P. S. Linsley. 1993. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB-1. J. Exp. Med. 177:165.
15. Williams, M. E., C. M. Shea, and A. K. Abbas. 1992. Antigen receptor-mediated anergy in resting T lymphocytes and T cell clones: correlation with lymphokine secretion patterns. J. Immunol. 149:1921.
16. Wolf, H., Y. Muller, S. Saimen, W. Wilmans, and G. Jung. 1994. Induction of anergy in resting human T lymphocytes by immobilized anti-CD3 antibodies. Eur. J. Immunol. 24:1410.
17. Chai, J.-G., and R. Lechler. 1997. Immobilized anti-CD3 mAb induces anergy in murine naive and memory CD4 T cells in vitro. Int. Immunol. 7:935.
18. Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1993. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature 363:156.
19. Jenkins, M. K. 1992. The role of cell division in the induction of clone anergy. Immunol. Today 13:69.
20. Lenschow, D. J., Y. Zeng, J. R. Thistlethwait, A. Montag, W. Bardy, M. G. Gibson, P. S. Linsley, and J. A. Bluestone. 1992. Long-term, survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig. Science 257:789.
21. Linsley, P. S., P. M. Wallace, J. Johnson, M. G. Gibson, J. L. Greene, J. A. Ledbetter, C. Singh, and M. A. Tepper. 1992. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science 257:792.
22. Lin, H., S. F. Bolling, P. S. Linsley, R. Q. Wei, D. Gordon, C. B. Thompson, and L. A. Turka. 1993. Long-term acceptance of major histocompatibility complex mismatched cardiac allograft induced by CTLA4Ig plus donor-specific transfusion. J. Exp. Med. 178:1801.
23. Cobbold, S. P., E. Adams, S. E. Marshall, J. D. Davies, and H. Waldmann. 1996. Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8. Immunol. Rev. 149:5.
24. Lamb, J. R., B. J. Skidore, N. Green, J. M. Chiller, and M. Feldmann. 1983. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J. Exp. Med. 157:1434.
25. Lamb, J. R., and M. Feldmann. 1984. Essential requirement for major histocompatibility complex in recognition in T cell tolerance induction. Nature 308:72.
26. Sidhu, S., S. Deacock, V. Bal, J. R. Batchelor, G. Lombardi, and R. L. Lechler. 1992. Human T cells cannot act as autonomous antigen-presenting cells, but induce tolerance in antigen-specific and alloreactive responder cells. J. Exp. Med. 176:875.
27. Lombardi, G., R. Hargreaves, S. Sidhu, N. Imami, L. Lightstone, S. Fuller-Espie, M. Ritter, P. Robinson, A. Tarnock, and R. I. Lechler. 1996. Antigen-presentation by T cells inhibits IL-2 production and induces IL-4 release due to altered cognate signals. J. Immunol. 156:2769.
28. Douek, D. C., K. T. T. Corley, T. Zal, A. Mellor, P. J. Dyson, and D. M. Altmann. 1996. Negative selection by endogenous antigen and superantigen occurs at multiple thymic sites. Int. Immunol. 8:1413.
29. Simpson, E., and K. Tomonari. 1989. Mapping minor H genes. Immunology 2(Suppl.):42.
30. Scott, D. M., I. E. Ehrmann, P. S. Ellis, C. E. Bishop, A. I. Agulnik, E. Simpson, and M. J. Mitchell. 1995. Identification of a mouse male-specific antigen, H-Y. Nature 376:695.
31. Antoniou, A. N., J. Elliott, E. Rosmarakis, and P. J. Dyson. 1998. H-2 Ab diabetogeneic residue 57 asp/non-asp dimorphism influences T cell recognition and selection. Immunogenetics. 47:218.
32. Cobbold, S. P., A. Jayasuriya, A. Nash, T. D. Propero, and H. Waldmann. 1984. Therapy with monoclonal antibodies by elimination of T-cell subset in vivo. Nature 312:548.
33. Lane, P., W. Gerhard, S. Hubele, A. Lanzavecchia, and F. McConnell. 1993. Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA-4 and human γ1. Immunology 80:56.
34. Gross, J. A., E. Callas, and J. P. Allison. 1992. Identification and distribution of the costimulatory receptor CD28 in the mouse. J. Immunol. 149:380.
35. Walunas, T. L., D. L. Lenschow, C. Y. Bakker, P. S. Linsley, G. J. Freeman, J. M. Green, and J. A. Bluestone. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1:405.
36. Goodman, T., and L. Lefrancois. 1989. Intraepithelial lymphocytes: anatomical site, not T cell receptor form, dictates phenotype and function. J. Exp. Med. 170:1569.
37. Inaba, K., M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, and M. Steinman. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176:1693.
38. Nicoletti, I., G. Migliorati, M. C. Pagliacci, F. Grignani, and C. Riccardi. 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139:271.
39. Sansom, D. M., and N. D. Hall. 1993. B7/BB1, the ligand for CD28, is expressed on repeatedly activated Human T cells in vitro. Eur. J. Immunol. 23:295.
40. Prabhu Das, M. R., S. S. Zamvil, F. Borriello, H. L. Weiner, A. H. Sharpe, and V. K. Kuchroo. 1995. Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation. Eur. J. Immunol. 25:207.
41. Azuma, M., H. Yssel, J. H. Phillips, H. Spits, and L. L. Lanier. 1992. Functional expression of B7/BB1 on activated T lymphocytes. J. Exp. Med. 177:845.
42. Miller, R. G. 1986. The veto phenomenon and T-cell regulation. Immunol. Today 7:112.
43. Fink, P. J., R. P. Shimonkevitz, and M. J. Bevan. 1988. Veto cells. Annu. Rev. Immunol. 6:115.
44. + cells whose class I MHC can bind the peptide. J. Immunol. 152:1103.
45. Ju, S.-T., D. J. Panka, H. Cul, R. Ettinger, M. El-Khatib, D. H. Sherr, B. Z. Stanger, and A. Marshak-Rothstein. 1995. Fas (CD95)/Fas L interactions required for programmed cell death after T-cell activation. Nature 373: 444.
46. Zhang, L., G. Fisher, R. E. Miller, J. Peschon, D. H. Lynch, and M. J. Lenardo. 1995. Induction of apoptosis in mature T cells by tumor necrosis factor. Nature 377:348.
47. Sambhara, S. R., and R. G. Miller. 1991. Programmed cell death of T cells signaled by the T cell receptor and a3 domain of class I MHC. Science 252:1424.
48. lck tyrosine kinases, leads to an alternative phenotype of TcR/CD3 -chain, and induces apoptosis. J. Immunol. 158: 3189.
49. Linsley, P. S. 1995. Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation? J. Exp. Med. 182:289.
50. Lenschow, D. L., T. L. Walunas, and J. A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233.
51. Chamber, C. A., and J. P. Allison. 1997. Costimulation in T cell response. Curr. Opin. Immunol. 9:396.
52. Krummel, M. F., and J. P. Allison. 1995. CD28 and CTLA-4 deliver opposing signals which regulate the response of T cells to stimulation. J. Exp. Med. 182:459.
53. June, C. H., J. A. Bluestone, L. M. Nadler, and C. B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today 15:321.
54. Marengere, L. E. M., P. Waterhouse, G. S. Duncan, H.-W., Mittrucker, G.-S. Feng, and T. W. Mak. 1996. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272:1170.
55. Gribben, J. G., G. J. Freeman, V. A. Boussiotis, P. Rennert, C. L. Jellis, E. Greenfield, M. Barber, V. A. Restivo, Jr., X. Ke, G. S. Gray, and L. M. Nadler. 1995. CTLA-4 mediates antigen-specific apoptosis of human T cells. Proc. Natl. Acad. Sci. USA 92:811.
56. Perez, V. L., L. V. Parijs, A. Biuckians, X. X. Zheng, T. B. Storm, and A. K. Abbas. 1997. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6:411.
57. Linsley, P. S., J. L. Greene, W. Brady, J. Bajorath, J. A. Ledbetter, and R. Peach. 1994. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1:793.
58. Van der Merwe, P. A., D. L. Bodian, S. Daenke, P. Linsley, and S. J. Davis. 1997. CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J. Exp. Med. 185:393.
59. Moss, D. J., S. R. Burrows, G. D. Baxter, and M. F. Lavin. 1991. T cell-T cell killing is induced by specific epitopes: evidence for an apoptotic mechanism. J. Exp. Med. 173:681.
60. + cytotoxic T lymphocytes is due to fratricide. J. Immunol. 151:658.
61. + cytolytic T lymphocytes. Proc. Natl. Acad. Sci. USA 87:9015.
62. Pemberton, R. M., D. C. Wraith, and B. A. Askonas. 1990. Influenza peptide-induced self-lysis and down-regulation of cloned cytotoxic T cells. Immunology 70:223.
63. + cytotoxic T lymphocytes by free antigenic peptide:a self-veto mechanism? J. Exp. Med. 183:879.
64. Matzinger, P. 1991. The JAM test: a simple assay for DNA fragmentation and cell death. J. Immunol. Methods 145:185.
65. Tanchot, C., F. A. Lemonnier, B. Perarnau, A. A. Freitas, and B. Rocha. 1997. Differential requirement for survival and proliferation of CD8 naive and memory T cells. Science 276:2057.