Neurological disturbances, premature lethality, and central myelination deficiency in transgenic mice overexpressing the homeo domain transcription factor Oct-6

Journal of Clinical Investigation

Volumn 101, Issue 6, 1998, Pages 1292-1299

  Jensen, Niels A ^a   Pedersen, Karen M ^a   Cells, Julio E ^a   West, Mark J ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Hypomyelination; Myelin basic protein; SCIP; Tst 1

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 6; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FATALITY; MOUSE; MYELIN DEFICIENCY; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; SEIZURE; TRANSGENIC MOUSE; TREMOR;

EID: 0032520907     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1807     Document Type: Article

References (58)

1. Raine, C.S. 1984. Morphology of myelin and myelination. In Myelin. P. Morell, editor. Plenum Publishing Corporation, New York. 1-50.
2. Pfeiffer, S.E., A.E. Warrington, and R. Bansal. 1993. The oligodendrocyte and its many cellular processes. Trends Cell Biol. 3:191-197.
3. Morell, P., R.H. Quarks, and W.T. Norton. 1994. Myelin formation, structure, and biochemistry. In Basic Neurochemistry: Molecular, Cellular, and Medical Aspects. G.J. Siegel, B.W. Agranoff, R.W. Albers, and P.B. Molinoff, editors. Raven Press, Ltd., New York. 117-143.
4. Campagnoni, A.T. 1995. Molecular biology of myelination. In Neuroglia. H. Kettenman and B.R. Ransom, editors. Oxford University Press. New York. 555-570.
5. Rosenbluth, J. 1995. Glial membranes and axoglial junctions. In Neuroglia. H. Kettenman and B.R. Ransom, editors. Oxford University Press. New York. 613-633.
6. Szuchet, S. 1995. The morphology and ultrastructure of oligodendrocytes and their functional implications. In Neuroglia. H. Kettenman and B.R. Ransom, editors. Oxford University Press, New York. 23-43.
7. Remahl, S., and C. Hildebrand. 1990. Relation between axons and oligodendroglial cells during initial myelination. J. Neurocytol. 19:313-328.
8. Butt, A.M., and B.R. Ransom. 1993. Morphology of astrocytes and oligodendrocytes during development in the intact rat optic nerve. J. Comp. Neurol. 338:141-158.
9. Bunge, R.P., and C. Fernandez-Valle. 1995. Basic biology of the Schwann cell. In Neuroglia. H. Kettenman and B.R. Ransom, editors. Oxford University Press, New York. 44-57.
10. Mirsky, R., and K.R. Jessen. 1996. Schwann cell development, differentiation and myelination. Curr. Opin. Neurobiol. 6:89-96.
11. Ruvkun, G., and M. Finney. 1991. Regulation of transcription and cell identity by POU domain proteins. Cell. 64:475-478.
12. Rosenfeld, M.G. 1991. POU-domain transcription factors: Pou-er-ful developmental regulators. Genes. Dev. 5:897-907.
13. Schöler, H.R. 1991. Octamania: the POU factors in murine development. Trends Genet. 7:323-329.
14. Herr, W., and M.A. Cleary. 1995. The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain. Genes Dev. 9:1679-1693.
15. Monuki, E.S., G. Weinmaster, R. Kuhn, and G. Lemke. 1989. SCIP: a glial POU domain gene regulated by cyclic AMP. Neuron. 3:783-793.
16. Suzuki, N., H. Rohdewohld, T. Neuman, P. Gruss, and H.R. Schöler. 1990. Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain. EMBO (Eur. mol. Biol. Organ) J. 9:3723-3732.
17. He, X., R. Gerrero, D.M. Simmons, R.E. Park, C.J. Lin, L.W. Swanson, and M.G. Rosenfeld. 1991. Tst-1, a member of the POU domain gene family, hinds the promoter of the gene encoding the cell surface adhesion molecule Po. Mol. Cell. Biol. 11:1739-1744.
18. Hara, Y., A.C. Rovescalli, Y. Kim, and M. Nirenberg. 1992. Structure and evolution of four domain genes expressed in mouse brain. Proc. Natl. Acad. Sci. USA. 89:3280-3284.
19. He, X., M.N. Treacy, D.M. Simmons, H.A. Ingraham, L.W. Swanson, and M.G. Rosenfeld. 1989. Expression of a large family of POU-domain regulatory genes in mammalian brain development. Nature. 340:501-506.
20. Spaniol, P., C. Bornmann, G. Hauplmann, and T. Gerster. 1996. Class III POU genes of zebrafish are predominantly expressed in the central nervous system. Nucleic Acids Res. 24:4874-4881.
21. Rohdewohld, H., and P. Gruss. 1992. The gene for the POU domain transcription factor Oct-6 maps to the distal end of mouse chromosome 4. Mnmm. Genome. 3:119-121.
22. Avraham, K.B., B.C. Cho, D. Gilbert, H. Fuji, K. Okamoto, T. Shimazaki, T. Ito, H. Shoji, Y. Wakamatzu, H. Kondoh, et al. 1993. Murine chromosomal location of four class III POU transcription factors. Genomics. 18: 131-133.
23. Meijer, D., A. Graus, R. Kraay, A. Langeveld, M.P. Mulder, and G. Grosveld. 1990. The octamer binding factor Oct-6: cDNA cloning and expression in early embryonic cells. Nucleic Acids Res. 9:2241-2247.
24. Abdel-Raliman, B., M. Fiddler, D. Rappolee, and E. Pergament. 1995. Expression of transcription regulating genes in human preimplantation embryos. Hum. Reprod. 10:2787-2792.
25. Zwart, R., L. Broos, G. Grosveld, and D. Meijer. 1996. The restricted expression pattern of the POU factor Oct-6 during early development of the mouse nervous system. Mech. Dev. 54:185-194.
26. Frantz, G.D., A.P. Bohner, R.M. Akers, and S.K. McConnell. 1994. Regulation of the POU domain gene SCIP during cerebral cortical development. J. Neurosci. 14:472-485.
27. Alvarez-Bolado, G., M.G. Rosenfeld, and L.W. Swanson. 1995. Model of forebrain regionalization based on spatiotemporal patterns of POU-III homeobox gene expression, birthdates, and morphological features. J. Comp. Neurol. 355:237-295.
28. Collarini, E.J., R. Kuhn, C.J. Marshall, E.S. Monuki, G. Lemke, and W.D. Richardson. 1992. Down-regulation of the POU transcription factor SCIP is an early event in oligodendrocyte differentiation in vitro. Development. 116: 193-200.
29. Faus, I., H.-J. Hsu, and E. Fuchs. 1994. Oct-6: A regulator of keratinocyte gene expression in stratified squamous epithelia. Mol. Cell. Biol. 14: 3263-3275.
30. Meijer, D., A. Graus, and G. Grosveld. 1992. Mapping the transactivalion domain of the Oct-6 POU transcription factor. Nucleic Acids Res. 20:2241-2247.
31. Monuki, E.S., R. Kuhn, and G. Lemke. 1993. Repression of the myelin Po gene by the POU transcription factor SCIP. Mech. Dev. 42:15-32.
32. Renner, K., H. Leger, and M. Wegner. 1994. The POU-domain protein Tst-1 and papovaviral T-antigen function synergistically to stimulate glia-specific gene expression of JC virus. Proc. Natl. Acad. Sci. USA. 91:6433-6437.
33. Leger, H., E. Sock, K. Renner, F. Grummt, and M. Wegner. 1995. Functional interaction between the POU domain protein Tst-1/oct-6 and the high-mobility-group protein HMG-I/Y. Mol. Cell Biol. 15:3738-3747.
34. Wegner, M., D.W. Drolet, and M.G. Rosenfeld. 1993. POU-domain proteins: structure and function of developmental regulators. Curr. Opin. Cell Biol. 5:488-498.
35. Scherer, S.S., D.-Y. Wang, R. Kuhn, G. Lemke, L. Wrabetz, and J. Kamholz. 1994. Axons regulate Schwann cell expression of the POU transcription factor SCIP. J. Neurosci. 14:1930-1942.
36. Blanchard, A.D., A. Sinanan, E. Parmantier, R. Zwart, L. Broos, D. Meijer, C. Meier, K.R. Jessen, and R. Mirsky. 1996. Oct-6 (SCIP/Tst-1) is expressed in Schwann cell precursors, embryonic Schwann cells, and postnatal myelinating Schwann cells: comparison with Oct-1, Krox-20, and Pax-3. J. Neurosci. Res. 46:630-640.
37. Bermingham, J.R., S.S. Scherer, S. O'Connell, E. Arroyo, K.A. Kalla. F.L. Powell, and M.G. Rosenfeld. 1996. Tst-1/Oct-6/SCIP regulates a unique step in peripheral myelination and is required for normal respiration. Genes Dev. 10:1751-1762.
38. Jaegle, M., W. Mandemakers, L. Broos, R. Zwart, A. Karis, P. Visser, F. Grosveld, and D. Meijer. 1996. The POU factor Oct-6 and Schwann cell differentiation. Science. 273:507-510.
39. Bögler, O., A. Entwistle, R. Kuhn, E. Monuki, G. Lemke, and M. Noble. 1993. Single cell analysis of the expression of a nuclear protein. SCIP. by fluorescent immunohistochemistry visualized with confocal microscopy. Histochem. J. 25:746-761.
40. Jensen, N.A., G.M. Smith, H.D. Shine, J.S. Garvey, and L. Hood. 1993. Distinct hypomyelinated phenotypes in MBP-SV40 large T transgenic mice. J. Neurosci. Res. 34:257-264.
41. Chirgwin, J.M., A.E. Przybyla, R.J. MacDonald, and W.J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:5294-5299.
42. Gavrieli, Y., Y. Sherman, and S.A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493-501.
43. Celis, J.E., J.B. Lauridsen, and B. Basse. 1997. Determination of antibody specificity by Western blotting and immunoprecipitation. In Cell Biology: A Laboratory Handbook (Vol. 2). J.E. Celis. N.P. Carter, T. Hunter, D.M. Shotton, K. Simons, and J.V. Small, edilors. Academic Press, Inc., San Diego. 429-437.
44. Celis, J.E., G. Ratz, B. Basse, J.B. Lauridsen, A. Celis, N.A. Jensen, and P. Gromov. 1997. High-resolution two-dimensional gel electrophoresis of proteins: isoelectric focusing (IEF) and nonequilibrium pH gradient electrophoresis (NEPHGE). Applications to the analysis of cultured cells and mouse knockouts. In Cell Biology: A Laboratory Handbook (Vol. 4). J.E. Celis, N.P. Carter, T. Hunter, D.M. Shotton, K. Simons, and J.V. Small, editors. Academic Press, Inc., San Diego. 375-385.
45. Monuki, E.S., R. Kuhn, G. Weinmaster, B.D. Trapp, and G. Lemke. 1990. Expression and activity of the transcription factor SCIP. Science. 249: 300-1303.
46. Weinstein, D.E., P.C. Burrola, and G. Lemke. 1995. Premature Schwann cell differentiation and hypermyelination in mice expressing a targeted antagonist of the POU transcription factor SCIP. Mol. Cell. Neurosci. 6: 212-229.
47. Jensen, N.A., K.M. Pedersen, J.E. Celis, and M.J. West. 1998. Failure of central nervous system myelination in MBP/c-myc transgenic mice: Evidence for c-myc cytotoxicity. Oneogene. In Press.
48. Waxman, S.G., and J.A. Black. 1995. Axoglial interactions at the cellular and molecular levels in central nervous system myelinated fibers. In Neuroglia. H. Kettenman and B.R. Ransom, editors. Oxford University Press, New York. 587-610.
49. Bradel, E.J., and F.P. Price. 1983. Cultured neonatal ral oligodcndrocytes elaborate myelin membrane in the absence of neurons. J. Neurosci. Res. 9: 381-392.
50. Rome, L.H., P.N. Bullock, F. Chiappelli, M. Cardwell, A.M. Adinoff, and D. Swanson. 1986. Synthesis of a myelin-like membrane by oligodendrocytes in culture. J. Neuroma. Res. 15:49-65.
51. Knapp, P.E., W.P. Bartlett, and R.P. Skoff. 1987. Cultured oligodendrocytes mimic in vivo phenotypic characteristics: cell shape, expression of myelin antigens, and membrane production. Dev. Biol. 120:356-365.
52. Notterpek, L.M., and L.H. Rome. 1994. Functional evidence for the role of axolemma in CNS myelination. Neuron. 13:473-485.
53. Gow, A., V.L. Friedrich, and R.A. Lazzarini. 1992. Myelin basic protein gene contains separate enhancers for oligodendrocyte and Schwann cell expression. J. Cell Biol. 119:605-616.
54. Raff, M.C., B.A. Barres, J.F. Burne, S.H. Coles, Y. Ishizaki, and M.D. Jacobson. 1993. Programmed cell death and the control of cell survival: lessons from the nervous system. Science. 262:695-700.
55. Barres, B.A., and M. Raff. 1996. Axonal control of oligodendrocyte development. In Glial Cell Development. K.R. Jessen and W.D. Richardson, editors. BIOS Scientific Publishers Limited, Oxford, United Kingdom. 71-83.
56. Wegner, M., D.W. Drolet, and M.G. Rosenfeld. 1993. Regulation of JC virus by the POU-domain transcription factor Tst-1: implications for progressive mullifocal leukoencephalopathy. Proc. Nutl. Acad. Sci. USA. 90:4743-4747.
57. Renner, K., E. Sock, J.K. Gerber, and M. Wegner. 1996. T antigen of human papovavirus JC stimulates transcription of the POU domain factor Tst-1/Oct-6/SCIP. DNA Cell Biol. 15:1057-1062.
58. Kamholz, J.A. 1996. Regulation of myelin development. Mult. Scler. 2: 236-240.