Mapping the active site of factor Xa by selective inhibitors: An NMR and MD study

Proteins: Structure, Function and Genetics

Volumn 30, Issue 3, 1998, Pages 264-274

  Fraternali, F ^a,d   Do, Q T ^a   Doan, B T ^a,e   Atkinson, R A ^a,f   Palmas, P ^a,g   Sklenar, V ^a   Safar, P ^c,h   Wildgoose, P ^b   Strop, P ^c   Saudek, V ^a  

^a SANOFI   (France)

^b DG Cardiovascular Diseases   (Germany)

^c Selectide Corporation   (United States)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^e SORBONNE UNIVERSITÉ   (France)

^f UNIVERSITÉ DE STRASBOURG   (France)

^g DIF   (France)

^h MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Active site inhibitors; Blood coagulation; Factor Xa; Serine proteinases; Transferred NOE

Indexed keywords

BLOOD CLOTTING FACTOR 10A;

ARTICLE; CATALYSIS; ENERGY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BINDING SITES; ENZYME INHIBITORS; FACTOR XA; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT;

EID: 0032519515     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(19980215)30:3<264::AID-PROT6>3.0.CO;2-K     Document Type: Article

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