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Volumn 101, Issue 2, 1998, Pages 503-510

Transplantable rat glucagonomas cause acute onset of severe anorexia and adipsia despite highly elevated NPY mRNA levels in the hypothalamic arcuate nucleus

Author keywords

Cancer; GLP 1; Glucagon; Hunger regulation; Leptin

Indexed keywords

LEPTIN; MESSENGER RNA; NEUROPEPTIDE Y; PROGLUCAGON;

EID: 0032518563     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI275     Document Type: Article
Times cited : (45)

References (78)
  • 2
    • 0027524724 scopus 로고
    • The dissociation of tumor-induced weight loss from hypoglycemia in a transplantable rat islet tumor results in the segregation of stable α- and β-cell tumor phenotypes
    • Madsen, O.D., C. Karlsen, E. Nielsen, K. Lund, H. Kofod, B. Welinder, J.F. Rehfeld, L.I. Larsson, D.F. Steiner, J.J. Holst, and B.K. Michelsen. 1993. The dissociation of tumor-induced weight loss from hypoglycemia in a transplantable rat islet tumor results in the segregation of stable α-and β-cell tumor phenotypes. Endocrinology. 133:2022-2030.
    • (1993) Endocrinology , vol.133 , pp. 2022-2030
    • Madsen, O.D.1    Karlsen, C.2    Nielsen, E.3    Lund, K.4    Kofod, H.5    Welinder, B.6    Rehfeld, J.F.7    Larsson, L.I.8    Steiner, D.F.9    Holst, J.J.10    Michelsen, B.K.11
  • 4
    • 0028861875 scopus 로고
    • Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis
    • Blume, N., J. Skouv, L.I. Larsson, J.J. Holst, and O.D. Madsen. 1995. Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis. J. Clin. Invest. 96:2227-2235.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2227-2235
    • Blume, N.1    Skouv, J.2    Larsson, L.I.3    Holst, J.J.4    Madsen, O.D.5
  • 5
    • 0019493506 scopus 로고
    • Tumor-induced anorexia in the wistar rat
    • Mordes, J.P., and A.A. Rossini. 1981. Tumor-induced anorexia in the wistar rat. Science. 213:565-567.
    • (1981) Science , vol.213 , pp. 565-567
    • Mordes, J.P.1    Rossini, A.A.2
  • 7
    • 0026708644 scopus 로고
    • Cancer cachexia is transmissible in plasma
    • Illig, K.A., N. Maronian, and J.L. Peacock. 1992. Cancer cachexia is transmissible in plasma. J. Surg. Res. 52:353-358.
    • (1992) J. Surg. Res. , vol.52 , pp. 353-358
    • Illig, K.A.1    Maronian, N.2    Peacock, J.L.3
  • 8
    • 0026775070 scopus 로고
    • Alterations in proglucagon processing and inhibition of proglucagon gene expression in transgenic mice which contain a chimeric proglucagon-SV40 T antigene gene
    • Brubaker, P.L., Y.C. Lee, and D.J. Drucker. 1992. Alterations in proglucagon processing and inhibition of proglucagon gene expression in transgenic mice which contain a chimeric proglucagon-SV40 T antigene gene. J. Biol. Chew. 267:20728-20733.
    • (1992) J. Biol. Chew. , vol.267 , pp. 20728-20733
    • Brubaker, P.L.1    Lee, Y.C.2    Drucker, D.J.3
  • 9
    • 0028057177 scopus 로고
    • Inhibition of pancreatic proglucagon gene expression in mice bearing subcutaneous endocrine tumors
    • Ehrlich, P., D. Tucker, S.L. Asa, P.L. Brubaker, and D.J. Drucker. 1994. Inhibition of pancreatic proglucagon gene expression in mice bearing subcutaneous endocrine tumors. Am. J. Physiol. 30:E662-E671.
    • (1994) Am. J. Physiol , vol.30
    • Ehrlich, P.1    Tucker, D.2    Asa, S.L.3    Brubaker, P.L.4    Drucker, D.J.5
  • 10
    • 2642638281 scopus 로고
    • Glucagon-producing tumors
    • S. Cohen, editor. Churchill Livingstone, New York
    • Holst, J.J. 1985. Glucagon-producing tumors. In Hormone Producing Tumors of the Gastrointestinal Tract. S. Cohen, editor. Churchill Livingstone, New York. 57-84.
    • (1985) Hormone Producing Tumors of the Gastrointestinal Tract , pp. 57-84
    • Holst, J.J.1
  • 12
    • 0027512170 scopus 로고
    • Cancer cachexia
    • Tisdale, M.J. 1993. Cancer cachexia. Anticancer Drugs. 4:115-125.
    • (1993) Anticancer Drugs , vol.4 , pp. 115-125
    • Tisdale, M.J.1
  • 14
    • 0028962849 scopus 로고
    • Purification and characterization of a lipid-mobilizing factor associated with cachexia-inducing tumors in mice and humans
    • McDevitt, T.M., P.T. Todorov, S.A. Beck, S.H. Kahn, and M.J. Tisdale. 1995. Purification and characterization of a lipid-mobilizing factor associated with cachexia-inducing tumors in mice and humans. Cancer Res. 55:1458-1463.
    • (1995) Cancer Res. , vol.55 , pp. 1458-1463
    • McDevitt, T.M.1    Todorov, P.T.2    Beck, S.A.3    Kahn, S.H.4    Tisdale, M.J.5
  • 15
    • 0022873040 scopus 로고
    • Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
    • Stanley, B.G., S.E. Kyrkouli, S. Lampert, and S.F. Leibowitz. 1986. Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides. 7:1189-1192.
    • (1986) Peptides , vol.7 , pp. 1189-1192
    • Stanley, B.G.1    Kyrkouli, S.E.2    Lampert, S.3    Leibowitz, S.F.4
  • 16
    • 0025764241 scopus 로고
    • Insatiable feeding evoked in rats by recurrent perfusion of neuropeptide Y in the hypothalamus
    • Paez, X., and R.D. Myers. 1991. Insatiable feeding evoked in rats by recurrent perfusion of neuropeptide Y in the hypothalamus. Peptides. 12:609-616.
    • (1991) Peptides , vol.12 , pp. 609-616
    • Paez, X.1    Myers, R.D.2
  • 17
    • 0026091168 scopus 로고
    • Hypothermia and feeding induced simultaneously in rats by perfusion of neuropeptide Y in preoptic area
    • Roscoe, A.K., and R.D. Myers. 1991. Hypothermia and feeding induced simultaneously in rats by perfusion of neuropeptide Y in preoptic area. Pharmacol. Biochem. Behav. 39:1003-1009.
    • (1991) Pharmacol. Biochem. Behav. , vol.39 , pp. 1003-1009
    • Roscoe, A.K.1    Myers, R.D.2
  • 18
    • 0021918223 scopus 로고
    • An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenalin in the rat
    • Bai, F.L., M. Yamano, Y. Shiotani, P.C. Emson, A.D. Smith, J.F. Powell, and M. Tohyama. 1985. An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenalin in the rat. Brain Res. 331:172-175.
    • (1985) Brain Res. , vol.331 , pp. 172-175
    • Bai, F.L.1    Yamano, M.2    Shiotani, Y.3    Emson, P.C.4    Smith, A.D.5    Powell, J.F.6    Tohyama, M.7
  • 19
    • 0025721025 scopus 로고
    • Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food
    • Kalra, S.P., M.G. Dube, A. Sahu, C.P. Phelps, and P.S. Kalra. 1991. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl. Acad. Sci. USA. 88:10931-10935.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 10931-10935
    • Kalra, S.P.1    Dube, M.G.2    Sahu, A.3    Phelps, C.P.4    Kalra, P.S.5
  • 20
    • 0028157404 scopus 로고
    • Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucleotides suppresses feeding behavior and insulin secretion
    • Akabayashi, A., C. Wahlestedt, J.T. Alexander, and S.F. Leibowitz. 1994. Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucleotides suppresses feeding behavior and insulin secretion. Brain Res. 21:55-61.
    • (1994) Brain Res. , vol.21 , pp. 55-61
    • Akabayashi, A.1    Wahlestedt, C.2    Alexander, J.T.3    Leibowitz, S.F.4
  • 21
    • 0025046607 scopus 로고
    • Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status
    • Beck, B., U.M. Jhanwar, A. Burlet, C.M. Chapleur, S.F. Leibowitz, and C. Burlet. 1990. Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status. Brain Res. 528:245-249.
    • (1990) Brain Res. , vol.528 , pp. 245-249
    • Beck, B.1    Jhanwar, U.M.2    Burlet, A.3    Chapleur, C.M.4    Leibowitz, S.F.5    Burlet, C.6
  • 22
    • 0025072899 scopus 로고
    • Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation
    • Sanacora, G., M. Kershaw, J.A. Finkelstein, and J.D. While. 1990. Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology. 127:730-737.
    • (1990) Endocrinology , vol.127 , pp. 730-737
    • Sanacora, G.1    Kershaw, M.2    Finkelstein, J.A.3    While, J.D.4
  • 23
    • 0028244966 scopus 로고
    • Role of hypothalamic neuropeptide Y gene expression in body weight regulation
    • Davies, L., and J.L. Marks. 1994. Role of hypothalamic neuropeptide Y gene expression in body weight regulation. Am. J. Physiol. 266:R1687-R1691.
    • (1994) Am. J. Physiol. , vol.266
    • Davies, L.1    Marks, J.L.2
  • 24
    • 0027074985 scopus 로고
    • Hypothalamic neuropeptide expression after food restriction in Zucker rats: Evidence of persistent neuropeptide Y gene activation
    • Pesonen, U., R. Huupponen, J. Rouru, and M. Koulu. 1992. Hypothalamic neuropeptide expression after food restriction in Zucker rats: evidence of persistent neuropeptide Y gene activation. Mol. Brain Res. 16:255-260.
    • (1992) Mol. Brain Res. , vol.16 , pp. 255-260
    • Pesonen, U.1    Huupponen, R.2    Rouru, J.3    Koulu, M.4
  • 25
    • 0025804616 scopus 로고
    • Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats
    • Schwartz, M.W., J.L. Marks, A.J. Sipols, D.G. Baskin, S.C. Woods, S.E. Kahn, and D. Porte. 1991. Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats. Endocrinology. 128:2645-2647.
    • (1991) Endocrinology , vol.128 , pp. 2645-2647
    • Schwartz, M.W.1    Marks, J.L.2    Sipols, A.J.3    Baskin, D.G.4    Woods, S.C.5    Kahn, S.E.6    Porte, D.7
  • 26
    • 0027285319 scopus 로고
    • Elevated neuropeptide Y in the arcuate nucleus of young obese Zucker rats may contribute to the development of their overeating
    • Beck, B., A. Burlet, R. Bazin, J. Nicolas, and C. Burlet. 1993. Elevated neuropeptide Y in the arcuate nucleus of young obese Zucker rats may contribute to the development of their overeating. J. Nutr. 123:1168-1172.
    • (1993) J. Nutr. , vol.123 , pp. 1168-1172
    • Beck, B.1    Burlet, A.2    Bazin, R.3    Nicolas, J.4    Burlet, C.5
  • 27
    • 0024516638 scopus 로고
    • Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozotocin-induced diabetic rats
    • Williams, G., J.S. Gill, Y.C. Lee, H.M. Cardoso, B.E. Okpere, and S.R. Bloom. 1989. Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozotocin-induced diabetic rats. Diabetes. 38:321-327.
    • (1989) Diabetes , vol.38 , pp. 321-327
    • Williams, G.1    Gill, J.S.2    Lee, Y.C.3    Cardoso, H.M.4    Okpere, B.E.5    Bloom, S.R.6
  • 28
    • 0025062613 scopus 로고
    • Increased hypothalamic content of preproneuropeptide-Y messenger ribonucleic acid in streptozotocin-diabetic rats
    • White, J.D., D. Olchovsky, M. Kershaw, and M. Berelowitz. 1990. Increased hypothalamic content of preproneuropeptide-Y messenger ribonucleic acid in streptozotocin-diabetic rats. Endocrinology. 126:765-772.
    • (1990) Endocrinology , vol.126 , pp. 765-772
    • White, J.D.1    Olchovsky, D.2    Kershaw, M.3    Berelowitz, M.4
  • 29
    • 0026010988 scopus 로고
    • Increased neuropeptide Y content in the arcuato-paraventricular hypothalamic neuronal system in both insulin-dependent and non-insulin-dependent diabetic rats
    • Abe, M., S. Masasyuki, H. Ikeda, and T. Shimazu. 1991. Increased neuropeptide Y content in the arcuato-paraventricular hypothalamic neuronal system in both insulin-dependent and non-insulin-dependent diabetic rats. Brain Res. 539:223-227.
    • (1991) Brain Res. , vol.539 , pp. 223-227
    • Abe, M.1    Masasyuki, S.2    Ikeda, H.3    Shimazu, T.4
  • 30
    • 0026490478 scopus 로고
    • Neuropeptide Y release from the paraventricular nucleus increases in association with hyperphagia in streptozotocin-induced diabetic rats
    • Sahu, A., C.A. Sninsky, C.P. Phelps, M.G. Dube, P.S. Kalra, and S.P. Kalra. 1992. Neuropeptide Y release from the paraventricular nucleus increases in association with hyperphagia in streptozotocin-induced diabetic rats. Endocrinology. 131:2979-2985.
    • (1992) Endocrinology , vol.131 , pp. 2979-2985
    • Sahu, A.1    Sninsky, C.A.2    Phelps, C.P.3    Dube, M.G.4    Kalra, P.S.5    Kalra, S.P.6
  • 31
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y., R. Proenca, M. Maffai, M. Barone, L. Leopold, and J.M. Friedman. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:425-432.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffai, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 32
    • 0027319108 scopus 로고
    • Increased neuropeptide Y messenger RNA and decreased neurotensin messenger RNA in the hypothalamus of the obese (ob/ ob) mouse
    • Wilding, J.P.H., S.G. Gilbey, C.J. Baileym R.A. Batt, G. Williams, M.A. Ghatei, and S.R. Bloom. 1993. Increased neuropeptide Y messenger RNA and decreased neurotensin messenger RNA in the hypothalamus of the obese (ob/ ob) mouse. Endocrinology. 132:1939-1944.
    • (1993) Endocrinology , vol.132 , pp. 1939-1944
    • Wilding, J.P.H.1    Gilbey, S.G.2    Baileym, C.J.3    Batt, R.A.4    Williams, G.5    Ghatei, M.A.6    Bloom, S.R.7
  • 35
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural network
    • Campfield, A.L., F.J. Smith, Y. Guisez, R. Devos, and P. Burn. 1995. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural network. Science. 269:546-549.
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, A.L.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 38
    • 0020456354 scopus 로고
    • Evidence that peak II GLI or enteroglucagon is identical to the C-terminal sequence (residues 33-69) of glicentin
    • Holst, J.J. 1983. Evidence that peak II GLI or enteroglucagon is identical to the C-terminal sequence (residues 33-69) of glicentin. Biochem. J. 207: 381-388.
    • (1983) Biochem. J. , vol.207 , pp. 381-388
    • Holst, J.J.1
  • 39
    • 0026027919 scopus 로고
    • Proglucagon products in plasma of non-insulin-dependent diabetics and nondiabetic controls in the fasting state and following oral glucose and intravenous arginine
    • Orskov, C., J. Jeppesen, S. Madsbad, and J.J. Holst. 1991. Proglucagon products in plasma of non-insulin-dependent diabetics and nondiabetic controls in the fasting state and following oral glucose and intravenous arginine. J. Clin. Invest. 87:415-123.
    • (1991) J. Clin. Invest. , vol.87 , pp. 415-1123
    • Orskov, C.1    Jeppesen, J.2    Madsbad, S.3    Holst, J.J.4
  • 40
    • 0022976649 scopus 로고
    • Cloned cell lines from a transplantable insulinoma are heterogeneous and express cholecystokinin in addition to islet hormones
    • Madsen, O.D., L.I. Larsson, J.F. Rehfeld, T. Schwartz, A. Lernmark, A. Labrecque, and D.F. Steiner. 1986. Cloned cell lines from a transplantable insulinoma are heterogeneous and express cholecystokinin in addition to islet hormones. J. Cell Biol. 103:2025-2034.
    • (1986) J. Cell Biol. , vol.103 , pp. 2025-2034
    • Madsen, O.D.1    Larsson, L.I.2    Rehfeld, J.F.3    Schwartz, T.4    Lernmark, A.5    Labrecque, A.6    Steiner, D.F.7
  • 41
    • 0027404877 scopus 로고
    • Neuropeptide Y mRNA and immunoreactivity in hypothalamic neuroendocrine neurons: Effects of adrenalectomy and chronic osmotic stimulation
    • Larsen, P.J., J.D. Mikkelsen, D.S. Jessop, S.L. Lightman, and H.S. Chowdrey. 1993. Neuropeptide Y mRNA and immunoreactivity in hypothalamic neuroendocrine neurons: effects of adrenalectomy and chronic osmotic stimulation. J. Neurosci. 13:1138-1147.
    • (1993) J. Neurosci. , vol.13 , pp. 1138-1147
    • Larsen, P.J.1    Mikkelsen, J.D.2    Jessop, D.S.3    Lightman, S.L.4    Chowdrey, H.S.5
  • 42
    • 0022972956 scopus 로고
    • Characterization, sequence, and expression of the cloned human neuropeptide Y gene
    • Minth, C.D., P.C. Andrews, and J.E. Dixon. 1986. Characterization, sequence, and expression of the cloned human neuropeptide Y gene. J. Biol. Chem. 261:11974-11979.
    • (1986) J. Biol. Chem. , vol.261 , pp. 11974-11979
    • Minth, C.D.1    Andrews, P.C.2    Dixon, J.E.3
  • 43
  • 44
    • 0029033031 scopus 로고
    • Cloning of rat obese cDNA and its expression in obese rats
    • Murakami, T., and K. Shima. 1995. Cloning of rat obese cDNA and its expression in obese rats. Biochem. Biophys. Res. Commun. 209:944-952.
    • (1995) Biochem. Biophys. Res. Commun. , vol.209 , pp. 944-952
    • Murakami, T.1    Shima, K.2
  • 46
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese with diabetes and normal mice
    • Coleman, D.L. 1973. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia. 9:294-298.
    • (1973) Diabetologia , vol.9 , pp. 294-298
    • Coleman, D.L.1
  • 47
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the ob (leptin) receptor
    • Chua, S.C., W.K. Chung, X.S. Wupeng, Y.Y. Zhang, S.M. Liu, L. Tartaglia, and R.L. Leibel. 1996. Phenotypes of mouse diabetes and rat fatty due to mutations in the ob (leptin) receptor. Science. 271:994-996.
    • (1996) Science , vol.271 , pp. 994-996
    • Chua, S.C.1    Chung, W.K.2    Wupeng, X.S.3    Zhang, Y.Y.4    Liu, S.M.5    Tartaglia, L.6    Leibel, R.L.7
  • 49
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
    • Chen, H., O. Charlat, L.A. Tartaglia, E.A. Woolf, X. Weng, S.J. Ellis, N.D. Lakey, J. Culpepper, K.J. Moore, R.E. Breitbart, et al. 1996. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell. 84:491-495.
    • (1996) Cell , vol.84 , pp. 491-495
    • Chen, H.1    Charlat, O.2    Tartaglia, L.A.3    Woolf, E.A.4    Weng, X.5    Ellis, S.J.6    Lakey, N.D.7    Culpepper, J.8    Moore, K.J.9    Breitbart, R.E.10
  • 50
    • 0025148434 scopus 로고
    • Pancreatic glucagon signals postprandial satiety
    • Geary, N. 1990. Pancreatic glucagon signals postprandial satiety. Nurosci. Biobehav. Rev. 14:323-338.
    • (1990) Nurosci. Biobehav. Rev. , vol.14 , pp. 323-338
    • Geary, N.1
  • 51
    • 0027530401 scopus 로고
    • Glucagon acts in the liver to control spontaneous meal size in rats
    • Geary, N., J.L. Sauter, and U. Noh. 1993. Glucagon acts in the liver to control spontaneous meal size in rats. Am. J. Physiol. 264.-R116-R122.
    • (1993) Am. J. Physiol. , vol.264
    • Geary, N.1    Sauter, J.L.2    Noh, U.3
  • 52
    • 0025813562 scopus 로고
    • Hepatic portal infusions of glucagon antibodies increases spontaneous meal size in rats
    • Sauter, J.L., U. Noh, and N. Geary. 1991. Hepatic portal infusions of glucagon antibodies increases spontaneous meal size in rats. Am. J. Physiol. 261:R162-R165.
    • (1991) Am. J. Physiol. , vol.261
    • Sauter, J.L.1    Noh, U.2    Geary, N.3
  • 57
    • 0029903111 scopus 로고    scopus 로고
    • Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I
    • Orskov, C., S.S. Poulsen, M. Moller, and J.J. Holst. 1996. Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I. Diabetes. 45:832-835.
    • (1996) Diabetes , vol.45 , pp. 832-835
    • Orskov, C.1    Poulsen, S.S.2    Moller, M.3    Holst, J.J.4
  • 58
    • 0029118049 scopus 로고
    • Degradation of glucose-dependent insulinotropic polypeptide (GIP) and truncated glucagon-like peptide1I (tGLP-1) in vitro and in vivo by dipeptidyl peptidase IV
    • Kieffer, T.J., C.H.S. McIntosh, and R.A. Pederson. 1995. Degradation of glucose-dependent insulinotropic polypeptide (GIP) and truncated glucagon-like peptide1I (tGLP-1) in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology, 136:3585-3596.
    • (1995) Endocrinology , vol.136 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.S.2    Pederson, R.A.3
  • 59
    • 2642608975 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes satiety and suppresses energy intake in humans
    • Flint, A., A. Raben, J.J. Holst, and A. Astrup. 1997. Glucagon-like peptide-1 promotes satiety and suppresses energy intake in humans. Int. J. Obes. 21(Suppl. 2):28.
    • (1997) Int. J. Obes. , vol.21 , Issue.2 SUPPL. , pp. 28
    • Flint, A.1    Raben, A.2    Holst, J.J.3    Astrup, A.4
  • 61
    • 0030886382 scopus 로고    scopus 로고
    • Plasma-concentration of total leptin and human lung-cancer-associated cachexia
    • Simon, J.P., A.M. Schols, L.A. Campfield, E.F. Wouters, and W.H. Saris. 1997. Plasma-concentration of total leptin and human lung-cancer-associated cachexia. Clin. Sci. 93:273-277.
    • (1997) Clin. Sci. , vol.93 , pp. 273-277
    • Simon, J.P.1    Schols, A.M.2    Campfield, L.A.3    Wouters, E.F.4    Saris, W.H.5
  • 62
    • 0023391387 scopus 로고
    • Neuropeptide regulation of appetite and weight
    • Morley, J.E. 1987. Neuropeptide regulation of appetite and weight. Endocr. Rev. 8:256-287.
    • (1987) Endocr. Rev. , vol.8 , pp. 256-287
    • Morley, J.E.1
  • 63
    • 0027453750 scopus 로고
    • Neuropeptide Y: A central regulator of energy homeostasis
    • White, J.D. 1993. Neuropeptide Y: a central regulator of energy homeostasis. Regul. Pept. 49:93-107.
    • (1993) Regul. Pept. , vol.49 , pp. 93-107
    • White, J.D.1
  • 64
    • 0028228615 scopus 로고
    • Neuropeptide Y and energy balance: One way ahead for the treatment of obesity?
    • Dryden, S., H. Frankish, Q. Wang, and G. Williams. 1994. Neuropeptide Y and energy balance: one way ahead for the treatment of obesity? Eur. J. Clin. Invest. 24:293-308.
    • (1994) Eur. J. Clin. Invest. , vol.24 , pp. 293-308
    • Dryden, S.1    Frankish, H.2    Wang, Q.3    Williams, G.4
  • 65
    • 0029035260 scopus 로고
    • Neuropeptide Y. The hypothalamus, and diabetes: Insights into the central control of metabolism
    • Frankish, H.M., S. Dryden, D. Hopkins, Q. Wang, and G. Williams. 1995. Neuropeptide Y. the hypothalamus, and diabetes: insights into the central control of metabolism. Peptides. 16:757-771.
    • (1995) Peptides , vol.16 , pp. 757-771
    • Frankish, H.M.1    Dryden, S.2    Hopkins, D.3    Wang, Q.4    Williams, G.5
  • 66
    • 0001157297 scopus 로고    scopus 로고
    • Central effects of neuropeptide Y with emphasis on its role in obesity and diabetes
    • L. Grundemar and S.R. Bloom. editors. Academic Press. San Diego
    • Turton, M.P., D. O'Shea, and S.R. Bloom. 1997. Central effects of neuropeptide Y with emphasis on its role in obesity and diabetes. In Neuropeptide Y and Drug Development. L. Grundemar and S.R. Bloom. editors. Academic Press. San Diego. 15-39.
    • (1997) Neuropeptide Y and Drug Development , pp. 15-39
    • Turton, M.P.1    O'Shea, D.2    Bloom, S.R.3
  • 67
    • 85050956429 scopus 로고
    • Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats
    • Vettor, R., N. Zarjevski, I. Cusin, F. Rohner-Jeanrenaud, and B. Jeanrenaud. 1994. Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats. Diabetologia. 37: 1202-1208.
    • (1994) Diabetologia , vol.37 , pp. 1202-1208
    • Vettor, R.1    Zarjevski, N.2    Cusin, I.3    Rohner-Jeanrenaud, F.4    Jeanrenaud, B.5
  • 68
    • 0028243332 scopus 로고
    • Chronic administration of glucocorticoids directly upregulates prepro-neuropeptide Y and Y1-receptor mRNA levels in the arcuate nucleus of the rat
    • Larsen, P.J., D.S. Jessop, H.S. Chowdrey, S.L. Lightman, and J.D. Mikkelsen. 1994. Chronic administration of glucocorticoids directly upregulates prepro-neuropeptide Y and Y1-receptor mRNA levels in the arcuate nucleus of the rat. J. Neuroendocrinol. 6:153-159.
    • (1994) J. Neuroendocrinol. , vol.6 , pp. 153-159
    • Larsen, P.J.1    Jessop, D.S.2    Chowdrey, H.S.3    Lightman, S.L.4    Mikkelsen, J.D.5
  • 69
    • 0026706582 scopus 로고
    • The effect of dexamethasone on neuropeptide Y concentration in specific hypothalamic regions
    • McKibbin, P.E., S.J. Cotton, D. McCarthy, and G. Williams. 1992. The effect of dexamethasone on neuropeptide Y concentration in specific hypothalamic regions. Life Sci. 51:1301-1307.
    • (1992) Life Sci. , vol.51 , pp. 1301-1307
    • McKibbin, P.E.1    Cotton, S.J.2    McCarthy, D.3    Williams, G.4
  • 70
    • 0026795166 scopus 로고
    • Glucocorticoids are required for food deprivation-induced increases in hypothalamic neuropeptide Y expression
    • Ponsalle, P., L.S. Srivastava, R.M. Uht, and J.D. White. 1992. Glucocorticoids are required for food deprivation-induced increases in hypothalamic neuropeptide Y expression. J. Neuroendocrinol. 4:585-591.
    • (1992) J. Neuroendocrinol. , vol.4 , pp. 585-591
    • Ponsalle, P.1    Srivastava, L.S.2    Uht, R.M.3    White, J.D.4
  • 71
    • 0029962023 scopus 로고
    • Reduced NPY induced feeding in diabetic but not steroid-treated rats: Lack of evidence for changes in receptor number or affinity
    • Morgan, D.G.A., P.D. Lambert, D.M. Smith, J.P.H. Wilding, and S.R. Bloom. 1946. Reduced NPY induced feeding in diabetic but not steroid-treated rats: lack of evidence for changes in receptor number or affinity. J. Neuroendocrinol. 8:283-290.
    • (1946) J. Neuroendocrinol. , vol.8 , pp. 283-290
    • Morgan, D.G.A.1    Lambert, P.D.2    Smith, D.M.3    Wilding, J.P.H.4    Bloom, S.R.5
  • 72
    • 0026528674 scopus 로고
    • Neuropeptide Y-stimulation of insulin secretion is mediated via the nucleus tractus solitarius
    • Dunhar, J.C., E. Ergene, and R.A. Barraco. 1992. Neuropeptide Y-stimulation of insulin secretion is mediated via the nucleus tractus solitarius. Horm. Metab. Rex. 24:103-105.
    • (1992) Horm. Metab. Rex. , vol.24 , pp. 103-105
    • Dunhar, J.C.1    Ergene, E.2    Barraco, R.A.3
  • 74
    • 0018621289 scopus 로고
    • Chronic intracerebroventricular infusions of insulin reduces food intake and body weight of baboons
    • Woods, S.C., E.C. Lotter, D.L. McKay, and D. Porte. 1979. Chronic intracerebroventricular infusions of insulin reduces food intake and body weight of baboons. Nature. 282:503-505.
    • (1979) Nature , vol.282 , pp. 503-505
    • Woods, S.C.1    Lotter, E.C.2    McKay, D.L.3    Porte, D.4
  • 75
    • 0017665552 scopus 로고
    • Increased feeding in response to bilateral injections of insulin antibodies in the VMH
    • Strubbe, J.H., and C.G. Mein. 1977. Increased feeding in response to bilateral injections of insulin antibodies in the VMH. Physiol. Behav. 19:309-313.
    • (1977) Physiol. Behav. , vol.19 , pp. 309-313
    • Strubbe, J.H.1    Mein, C.G.2
  • 78
    • 0029963167 scopus 로고    scopus 로고
    • A role for central glucagon-like peplide-1 in temperature regulation
    • O'Shea, D., I. Gunn, X.H. Chen, S. Bloom, and J. Herbert. 1996. A role for central glucagon-like peplide-1 in temperature regulation. Neuroreport. 7: 830-832.
    • (1996) Neuroreport , vol.7 , pp. 830-832
    • O'Shea, D.1    Gunn, I.2    Chen, X.H.3    Bloom, S.4    Herbert, J.5


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