The tetravalent guanylhydrazone CNI-1493 blocks the toxic effects of interleukin-2 without diminishing antitumor efficacy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 8, 1998, Pages 4561-4566

  Kemeny, M Margaret ^a   Botchkina, Galina I ^b   Ochani, Mahander ^a   Bianchi, Marina ^b   Urmacher, Carlos ^a   Tracey, Kevin J ^b  

^a NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^b PICOWER INST FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDINOHYDRAZONE; INTERLEUKIN 2; NITRIC OXIDE; SEMAPIMOD; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG ANTAGONISM; IMMUNOCYTOCHEMISTRY; LIVER CELL CARCINOMA; MACROPHAGE ACTIVATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CHROMATIN; HEPATIC ARTERY; HUMANS; HYDRAZONES; IMMUNOHISTOCHEMISTRY; INFUSIONS, INTRA-ARTERIAL; INFUSIONS, INTRAVENOUS; INTERLEUKIN-2; JUGULAR VEINS; KIDNEY; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; LUNG; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SURVIVAL RATE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0032516008     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.8.4561     Document Type: Article

References (27)

1. Rosenberg, S. A., Lotze, M. T., Muul, L. M., Leitman, M. T., Chang, A. E., Ettinghausen, S. E., Matory, Y. L., Skibber, J. M., Shiloni, E., Vetto, J. T., Seipp, C. A., Simpson, C. & Reichert, C. M. (1985) N. Engl. J. Med. 313, 1485-1492.
2. West, W. H., Tauer, K. W., Yannelli, J. R., Marshall, G. D., Orr, D. W., Thurman, G. B. & Oldham, R. K. (1987) N. Engl. J. Med. 316, 898-905.
3. Lotze, M. T., Chang, A. E., Seipp, G. A., Simpson, C., Vetto, J. T. & Rosenberg, S. A. (1986) JAMA 256, 3117-3124.
4. Rosenberg, S. A., Lotze, M. T., Yang, J. C., Aebersold, P. M., Linehan, W. M., Seipp, C. A. & White, D. E. (1989) Ann. Surg. 210 (4), 474-483.
5. Gemlo, B. T., Palladino, M. A., Jaffe, H. S., Espevik, T. P. & Rayner, A. A. (1988) Cancer Res. 48, 5864-5867.
6. Kasid, A., Director, E. P. & Rosenberg, S. A. (1989) J. Immunol. 143, 736-739.
7. Fraker, D. L., Langstein, H. N. & Norton, J. A. (1989) J. Exper. Med. 170, 1015-1020.
8. Edwards, M. J., Abney, D. L. & Miller, F. N. (1991) Surgery 110, 199-204.
9. Edwards, M. J., Heniford, T. B., Klar, E. A., Doak, K. W., Miller, F. N. (1992) J. Clin. Invest. 90, 637-641.
10. Margolin, K., Atkins, M., Sparano, J., Sosman, J., Weiss, G., Lotze, M., Doroshow, J., Mier, J., O'Boyle, K., Fisher, R., Campbell, E., Rubin, J., Federighi, D. & Bursten, S. (1997) Clin. Cancer Res. 3, 565-572.
11. Bianchi, M., Bloom, O., Raabe, T., Cohen, P. S., Chesney, J., Sherry, B., Schmidtmayerova, H., Calandra, T., Zhang, X., Bukrinsky, M., et al. (1996) J. Exp. Med. 183, 927-936.
12. Kemeny, M. M., Alava, G., Oliver, J. M. & Smith, F. B. (1992) HPB Surg. 5, 185-194.
13. Kemeny, M. M., Alava, G. & Oliver, J. M. (1994) HPB Surg. 7, 219-224.
14. Breder, C. D., Tsujimoto, M., Terano, Y., Scott, D. W. & Saper, C. B. (1993) J. Comp. Neurol. 337, 543-567.
15. Kemeny, M. M., Alava, G., Oliver, J. M. & Smith, F. B. (1992) Reg. Cancer Treat. 4, 260-264.
16. Hibbs, J. B., Westenfelder, C., Taintor, R., Vavrin, Z., Kablitz, C., Baranowski, R. L., Ward, J. H., Menlove, R. L., McMurry, M. P., Kushner, J. P., et al. (1992) J. Clin. Invest. 89, 867-877.
17. DuBois, J. S., Trehu, E. G., Mier, J. W., Shapiro, L., Epstein, M., Klempner, M., Dinarello, C., Kappler, K., Ronayne, L., Rand, W., et al. (1997) J. Clin. Oncol. 15, 1052-1062.
18. Kemeny, M. M., Alava, G. & Oliver, J. M. (1992) J. Immunother. 12, 219-223.
19. Montel, A. H, Bochan, M. R., Hobbs, J. A., Lynch, D. H. & Brahmi, Z. (1995) Cell. Immunol. 166, 236-246.
20. Strieter, R. M., Remick, D. G, Lynch, J. P., Spengler, R. N. & Kunkel, S. L. (1988) Am. Rev. Respir. Dis. 139, 335-342.
21. Nakagawa, K., Miller, F. N., Sims, D. E., Lentsch, A. B., Miyazaki, M. & Edwards. M. J. (1996) Cancer Res. 56, 507-510.
22. Cohen, P. S., Schmidtmayerova, H., Dennis, J., Dubrovsky, L., Sherry, B., Wang, H., Bukrinsky, M. & Tracey, K. J. (1997) Mol. Med. 3(5), 339-346.
23. Novikoff, A. B. (1957) Cancer Res. 17, 1010-1027.
24. Bianchi, M., Ulrich, P., Bloom, O., Meistrell, M. E., Zimmerman, G. A., Schmidtmayerova, H., Bukrinsky, M., Donnelley, T., Bucala, R., Sherry, B. et al. (1995) Mol. Med. 1(3), 254-266.
25. Meistrell, M. E., Botchkina, G. I., Wang, H., DeSanto, E., Cockroft, K. M., Bloom, O., Vishnubhakat, J. M., Ghezzi, P. & Tracey, K. J. (1997) Shock 8(5), 341-348.
26. Villa, P., Meazza, C., Sironi, M., Bianchi, M., Ulrich, P., Botchkina, G., Tracey, K. J. & Ghezzi, P. (1997) J. Endotoxin Res. 4(3), 197-204.
27. Denham, W., Fink, G., Yang, J., Ulrich, P., Tracey, K. & Norman, J. (1997) Am. Surg. 63(12), 1045-1049.