Small molecule inhibition of tumor necrosis factor gene processing during acute pancreatitis prevents cytokine cascade progression and attenuates pancreatitis severity

American Surgeon

Volumn 63, Issue 12, 1997, Pages 1045-1050

  Denham, Woody ^a   Fink, Gregory ^a   Yang, Jun ^a   Ulrich, Peter ^b   Tracey, Kevin ^b   Norman, James ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b PICOWER INST FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDINOHYDRAZONE; CYTOKINE; INTERLEUKIN 1BETA; SEMAPIMOD; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; INFLAMMATION; LUNG FUNCTION; NONHUMAN; PANCREAS NECROSIS; PATHOGENESIS; PROTEIN PROCESSING;

AMYLASES; ANIMALS; CAERULEIN; CHOLINE DEFICIENCY; DISEASE MODELS, ANIMAL; DNA PRIMERS; FEMALE; GASTROINTESTINAL AGENTS; GENE EXPRESSION REGULATION; HYDRAZONES; INTERLEUKIN-1; LIPASE; MALE; MICE; PANCREATITIS, ACUTE NECROTIZING; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0030831395     PISSN: 00031348     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Steinberg W, Tenner S. Acute pancreatitis. New Engl J Med 1994;330:1198-220.
2. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996;87:2095-147.
3. Norman J, Franz M, Riker A, Gower WR. Rapid elevation of pro-inflammatory cytokines during acute pancreatitis and their origination within the pancreas. Surg Forum, 1994 XLV:148-50.
4. Grewall HP, Kotb M, Ohman M, et al. Induction of tumor necrosis factor in severe acute pancreatitis and its subsequent reduction after hepatic passage. Surgery 1994;115:213-21.
5. Norman J, Fink G, Franz M. Acute pancreatitis induces intrapancreatic tumor necrosis factor-α gene expression. Arch Surg 1995;130:966-70.
6. Hughes C, Gaber L, Kotb M, et al. Induction of acute pancreatitis in germ-free rats: Evidence of a primary role for tumor necrosis factor-alpha. Surgery 1995;117:201-5.
7. Fink G, Norman J. Intrapancreatic interleukin-1β gene expression by specific leukocyte populations during acute pancreatitis. J Surg Res 1996;63:369-73.
8. Gross V, Leser HG, Heinisch A, Scholmerich J. Inflammatory mediators and cytokines: New aspects of the pathophysiology and assessment of severity of acute pancreatitis. Hepato-Gastroenterol 1993;40:522-30.
9. Norman J, Fink G, Denham W, et al. Tissue specific cytokine production during experimental acute pancreatitis: A probable mechanism for distant organ dysfunction. Dig Dis Sci 1997;42:1783-8.
10. McKay C, Gallagher G, Baxter JN, Imrie CW. Systemic complications in acute pancreatitis are associated with increased monocyte cytokine release. Gut 1994;35:A575.
11. Norman J, Franz M, Messina J, et al. Interleukin-1 receptor antagonist decreases severity of experimental pancreatitis. Surgery 1995;117:648-55.
12. Norman J, Franz M, Fink G, et al. Decreased mortality of severe acute pancreatitis after proximal cytokine blockade. Ann Surg 1995;221:625-34.
13. Tanaka N, Murata A, Uda K, et al. Interleukin-1 receptor antagonist modifies the changes in vital organs induced by acute pancreatitis in a rat experimental model. Crit Care Med 1995;23: 901-8.
14. Grewal HP, Money el-Din A, Gaber L, et al. Amelioration of the physiologic and biochemical changes of acute pancreatitis using and anti-TNF-α polyclonal antibody. Am J Surg 1994;167: 214-9.
15. Hughes CB, Grewall HP, Gaber LW, et al. Anti-TNF therapy improves survival and ameliorates the pathophysiologic sequelae in acute pancreatitis in the rat. Am J Surg 1996;171:274-80.
16. Norman J, Fink G, Franz M. Timing of tumor necrosis factor antagonism is critical in determining survival during experimental acute pancreatitis. Surgery 1996;120:515-21.
17. Hughes CB, Gaber L, Mohey el-Din A, et al. Inhibition of TNFα improves survival in an experimental model of acute pancreatitis. Am Surg 1996;62:1-6.
18. Bianchi M, Bloom O, Raabe T, et al. Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone. J Exp Med 1996;96:927-36.
19. Cohen P, Nakshatri H, Dennis J, et al. CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency. Proc Natl Acad Sci USA 1996;93:3967-71.
20. Manso MA, San Roman JI, de Dios I, et al. Caerulein-induced acute pancreatitis in the rat. Dig Dis Sci 1992;37:364-8.
21. Lombardi B, Estes LW, Longnecker DS. Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-etionine fed with a choline-deficient diet. Am J Pathol 1975;79:465-75.
22. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
23. Wang AM, Doyle MV, Mark DF. Quantification of mRNA by the polymerase chain reaction. Proc Natl Acad Sci USA 1989; 86:9717-21.
24. Diviacco S, Norio P, Zentilin L, et al. A novel procedure for quantitative polymerase chain reaction by coamplification of competitive templates. Gene 1992;122:313-20.
25. Tani S, Otsuki M, Itoh H, et al. Histologic and biochemical alterations in experimental acute pancreatitis induced by supramaximal caerulein stimulation. Int J Pancreatol 1987;2:337-48.