Vertical-scanning mutagenesis of a critical tryptophan in the minor groove binding track of HIV-1 reverse transcriptase: Molecular nature of polymerase-nucleic acid interactions

Journal of Biological Chemistry

Volumn 273, Issue 46, 1998, Pages 30435-30442

  Beard, William A ^a   Bebenek, Katarzyna ^a   Dardenn, Thomas A ^a   Li, Leping ^a   Prasad, Rajendra ^a   Kunkel S, Thomas A ^a   Wilson, Samuel H ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DNA; DNA BINDING PROTEIN; MUTANT PROTEIN; RNA DIRECTED DNA POLYMERASE; TRYPTOPHAN; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DISSOCIATION; DNA PROTEIN COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION;

ANTIVIRAL AGENTS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DNA; FRAMESHIFT MUTATION; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; MUTAGENESIS; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; THYMINE NUCLEOTIDES; TRYPTOPHAN; ZIDOVUDINE;

EID: 0032515080     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.46.30435     Document Type: Article

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