Synthesis and pharmacological characterization of O-alkynyloximes of tropinone and N-methylpiperidinone as muscarinic agonists

Journal of Medicinal Chemistry

Volumn 41, Issue 17, 1998, Pages 3220-3231

  Xu, Rong ^a   Sim, Meng Kwoon ^a   Go, Mei Lin ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR AGONIST; MUSCARINIC M2 RECEPTOR AGONIST; MUSCARINIC M3 RECEPTOR AGONIST; O (1 ETHYLPROP 2 YNYL)OXIME; O (1 METHYLBUT 3 YNYL)OXIME; O (BUT 2 YNYL)OXIME; PIPERIDONE DERIVATIVE; TROPINONE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; MOUSE; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; AORTA; BINDING, COMPETITIVE; DRUG DESIGN; ESCAPE REACTION; MALE; MAZE LEARNING; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUSCARINIC AGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; N-METHYLSCOPOLAMINE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PIPERIDINES; PIRENZEPINE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP; TROPANES;

EID: 0032514387     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9708588     Document Type: Article

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