Synthesis and muscarinic M3 pharmacological activities of 1-azabicyclo [2.2.2] octan-3-one oxime derivatives

Bioorganic and Medicinal Chemistry

Volumn 4, Issue 2, 1996, Pages 239-245

  Plate, Ralf ^a   Plaum, Marc J M ^a   De Boer, Thijs ^a   Andrews, John S ^a  

^a NV ORGANON   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CAVIA PORCELLUS; SUS SCROFA;

1 ARABICYCLO[2.2.2]OCTAN 3 ONE HYDROXYLAMINE DERIVATIVE; 1 AZABICYCLO[2.2.2]OCTAN 3 ONE OXIME DERIVATIVE; BICYCLO[2.2.2]OCTANE DERIVATIVE; MUSCARINIC M3 RECEPTOR; UNCLASSIFIED DRUG; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; OXIME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; ILEUM; MALE; MEMORY; MOUSE; MYDRIASIS; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SALIVATION; SMOOTH MUSCLE CONTRACTION; STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING COMPETITION; BRAIN; CHEMICALLY INDUCED DISORDER; CHEMISTRY; COGNITIVE DEFECT; DRUG EFFECT; IN VITRO STUDY; MAZE TEST; METABOLISM; MUSCLE CONTRACTION; SMOOTH MUSCLE; SYNTHESIS; WISTAR RAT;

ANIMALS; BINDING, COMPETITIVE; BRAIN; COGNITION DISORDERS; GUINEA PIGS; ILEUM; MALE; MAZE LEARNING; MEMORY; MICE; MUSCARINIC AGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYDRIASIS; OXIMES; RATS; RATS, WISTAR; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; SALIVATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029665797     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/0968-0896(96)00035-1     Document Type: Article

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