Apolipoprotein E ε2 does not increase risk of early-onset sporadic Alzheimer's disease

Annals of Neurology

Volumn 42, Issue 3, 1997, Pages 376-378

  Scott, W K ^a,b   Saunders, A M ^a   Gaskell, P C ^b   Locke, P A ^c   Growdon, J H ^d   Farrer, L A ^e   Auerbach, S A ^a   Roses, A D ^b   Haines, J L ^c   Pericak Vance, M A ^d  

^a Section of Medical Genetics   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c Molecular Neurogenetics Unit   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E2; APOLIPOPROTEIN E;

ADULT; AGE DISTRIBUTION; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE FREQUENCY; GENETIC RISK; GENOTYPE; HIGH RISK POPULATION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; AGED; ALLELE; COMPARATIVE STUDY; GENETICS; MIDDLE AGED; RISK FACTOR;

ADULT; AGE OF ONSET; AGED; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEINS E; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; RISK FACTORS;

EID: 0030612492     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410420317     Document Type: Article

References (20)

1. Goate A, Chartier-Harlin M-C, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991:349:704-706
2. Sherrington R, Rogaev E, Liang Y, et al. Cloning of a novel gene bearing missense mutations in early familial Alzheimer's disease. Nature 1995:375:754-760
3. Levy-Lahad E, Wasco W, Poorkaj P, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995:269:973-977
4. Rogaev El, Sherrington R, Rogaeva EA, et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 1995:376:775-778
5. Corder EH, Saunders AM, Strittmatter WJ, et al. Apolipoprotein E4 gene dose and the risk of Alzheimer disease in late onset families. Science 1993:261:921-923
6. Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease. Proc Natl Acad Sei USA 1993:90:1977-1981
7. Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993:43:1467-1472
8. Van Duijn CM, deKnijff P, Cruts M, et al. Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease. Nat Genet 1994:7:74-78
9. Okuizumi K, Onodera O, Tanaka H, et al. ApoE-E4 and earlyonset Alzheimer's. Nat Genet 1994:7:10-11
10. Pericak-Vance MA, Haines JL. Genetic susceptibility to Alzheimer disease. Trends Genet 1995:11:504-508
11. Corder EH, Saunders AM, Risch NJ, et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet 1994:7:180-184
12. Chartier-Harlin M-C, Parfitt M, Legrain S, et al. Apolipoprotein E, £4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region. Hum Mol Genet 1994:3:569-574
13. Rubinsztein DC, Hanlon CS, Irving RM, et al. Apo E genotypes in multiple sclerosis, Parkinson's disease, schwannomas and late-onset Alzheimer's disease. Mol Cell Probes 1994;8: 519-525
14. West HL, Rebeck GW, Hyman BT. Frequency of tric apolipoprotein E ε2 allele is diminished in sporadic Alzheimer disease. Neurosci Lett 1994:175:46-48
15. Locke PA, Conneally PM, Tanzi RE, et al. Apolipoprotein E4 allele and Alzheimer disease: examination of alleleic association and effect on age at onset in both early- and late-onset cases. Genet Epidemiol 1995:12:83-92
16. Sorbi S, Nacmias B, Forleo P, et al. ApoE allele frequencies in Italian sporadic and familial Alzheimer's disease. Neurosci Lett 1994:177:100-102
17. Van Duijn CM, de Knijff P, Wehnert A, et al. The apolipoprotein E E2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival. Ann Neurol 1995; 37:605-610
18. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984:34:939-944
19. Schlesselman JJ. Case-control studies: design, conduct, analysis. New York: Oxford University Press, 1982:153
20. ACMG/ASHG working group. Statement on use of apolipoprotein E testing for Alzheimer disease. JAMA 1995:274: 1627-1629