Serotonin-immune interactions in detoxified chronic alcoholic patients without apparent liver disease: Activation of the inflammatory response system and lower plasma total tryptophan

Psychiatry Research

Volumn 78, Issue 3, 1998, Pages 151-161

  Maes, Michael ^a,b   Lin, Ai Hua ^a   Bosmans, Eugene ^c   Vandoolaeghe, Eric ^a   Bonnacorso, Stefania ^a,d   Kenis, Gunter ^e   De Jongh, Raf ^e   Verkerk, Robert ^a   Song, Cai ^a,f   Scharpé, Simon ^a   Neels, Hugo ^g  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b Psychopharmacology Div Depts P   (United States)

^c Eurogenetics   (Belgium)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e AZ St Jan ^*  (Belgium)

^f CARLETON UNIVERSITY   (Canada)

^g Laboratory of Clinical Biology   (Belgium)

Author keywords

Alcoholism; CC16; Cytokines; Interleukin 6; Interleukin 8; Serotonin

Indexed keywords

CD14 ANTIGEN; CELL PROTEIN; CLARA CELL PROTEIN; CYTOKINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 8; ISOLEUCINE; LEUCINE; PHENYLALANINE; SEROTONIN; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; VALINE;

ADULT; ALCOHOL CONSUMPTION; ALCOHOLISM; AMINO ACID BLOOD LEVEL; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; DETOXIFICATION; DISEASE ASSOCIATION; FEMALE; HUMAN; INFLAMMATION; LIVER DISEASE; MALE; PRIORITY JOURNAL;

ADULT; ALCOHOLISM; ANTIGENS, CD; ANTIGENS, CD14; CYTOKINE RECEPTOR GP130; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MEMBRANE GLYCOPROTEINS; PROTEINS; RECEPTORS, INTERLEUKIN-6; SEROTONIN; SIALOGLYCOPROTEINS; TRYPTOPHAN; UTEROGLOBIN;

EID: 0032496094     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1781(98)00010-9     Document Type: Article

References (68)

1. APA, 1987. Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association, Washington, DC.
2. Ashley D.V.M., Barclay D.V., Chauffard F.A. Plasma amino acid responses in humans to evening meals of differing nutritional composition. American Journal of Clinical Nutrition. 36:1982;143-153.
3. Ashley D.V.M., Liardon R., Leathwood P.D. Breakfast meal composition influences plasma tryptophan to large neutral amino acid ratios of healthy lean young men. Journal of Neural Transmission. 63:1985;271-283.
4. Badawy A.A.-B., Morgan C.J., Lovett J.W., Bradley D.M., Thomas R. Decrease in circulating tryptophan availability to the brain after acute ethanol consumption by normal volunteers: implications for alcohol-induced aggressive behavior and depression. Pharmacopsychiatry. 28:1995;93-97.
5. Baker R.C., Jerrels T.R. Recent developments in alcoholism: immunological aspects. Recent Advances in Alcoholism. 11:1993;249-271.
6. Beck O., Borg S., Holmstedt B., Kvande H., Skroder R. Concentration of serotonin metabolites in the cerebrospinal fluid from alcoholics before and during disulfiram therapy. Acta Pharmacologica et Toxicologica. 47:1980;305-307.
7. Benigni F., Fantuzzi G., Sacco S., Sironi M., Pozzi P., Dinarello C.A., Sipe J.D., Poli V., Cappelletti M. Six different cytokines that share GP 130 as receptor subunit. Blood. 87:1996;1851-1854.
8. Branchey L., Lieber C.S. Activation of tryptophan pyrrolase after chronic alcohol administration. Substance and Alcohol Actions of Misuse. 2:1982;225-229.
9. Branchey L., Branchey M., Shaw S., Lieber C.S. Depression, suicide and aggression in alcoholics and their relationship to plasma amino acids. Psychiatry Research. 12:1984;219-226.
10. Branchey L., Shaw S., Lieber C.S. Ethanol impairs tryptophan transport into the brain and depresses serotonin. Life Sciences. 29:1981;2751-2755.
11. Brown R.R., Lee C.M., Kohler P.C., Hank J.A., Storer B.E., Sondel P.M. Altered tryptophan and neopterin metabolism in cancer patients treated with recombinant interleukin-2. Cancer Research. 49:1989;4941-4944.
12. Buydens-Branchey L., Branchey M., Worner T.M., Zucker D., Aramsombatdee E., Lieber C.S. Increase in tryptophan oxygenase activity in alcoholic patients. Alcoholism: Clinical and Experimental Research. 12:1988;163-167.
13. Cavaillon, J.-M., 1996. Les Cytokines, Masson, Paris.
14. Cook R.T., Garvey M.J., Booth B.M., Goeken J.A., Stewart B., Noel M. Activated CD-8 cells and HLA DR expression in alcoholics without overt liver disease. Journal of Clinical Immunology. 11:1991;246-253.
15. Curzon, G., 1990. Availability of amino acids to the brain and implication for transmitter amine function. In: Richardson, M.A. (Ed.), Amino Acids in Psychiatric Disease. American Psychiatric Press, Washington DC, pp. 33-48.
16. Curzon, G., Sarna, G.S., 1984. Tryptophan transport to the brain: newer findings and older ones reconsidered. In: Schlossberger, H.G., Kochen, W., Linzen, B., Steinhart, H. (Eds.), Progress in Tryptophan and Serotonin Research. Walter De Gruyter, Berlin-New York, pp. 145-157.
17. Dayer J.M., Burger D. Interleukin-1, tumour necrosis factor and their specific inhibitors. European Cytokine Network. 5:1994;563-571.
18. De Groote D., Zangerle P.F., Gevaert Y., Fassotte M.F., Beguin Y., Noizat-Pirenne F., Pirenne J., Gathy R., Lopez M., Dehart I., Igot D., Baudrihaye M., Delacroix D., Franchimont P. Direct stimulation of cytokines (IL-1β, TNF-α, IL-6, IL-2, IFN-γ and GM-CSF) in whole blood. I. Comparison with isolated PBMC stimulation. Cytokine. 4:1992;239-248.
19. Dierynck, I., Bernard, A., Roels, H., De Ley, M., 1995. Potent inhibition of both human interferon-gamma production and biologic activity by the Clara cell protein CC16. American Journal of Respiratory Cell and Molecular Biology 12, 205-210.
20. Dinarello C.A. The biological properties of interleukin-1. European Cytokine Network. 5:1994;517-531.
21. Eriksson T., Magnusson T., Carlson A., Hagman M., Jagenburg R. Decrease in plasma amino acids in man after an acute dose of ethanol. Journal of Studies on Alcohol. 44:1983;215-221.
22. Fernstrom, J.D., 1984. Tryptophan availability and serotonin synthesis in rat brain: effects of experimental diabetes. In: Schlossberger, H.G., Kochen, W., Linzen, B., Steinhart, H. (Eds.), Progress in Tryptophan and Serotonin Research. Walter de Gruyter, Berlin-New York, pp. 161-172.
23. Fernstrom J.D., Fernstrom M.H., Grubb P.E. Twenty-four hour variations in rat blood and brain levels of the aromatic and branched-chain amino acids: chronic effects of dietary protein content. Metabolism. 36:1987;643-650.
24. Friedman M.J., Krstulovic A.M., Severinghaus J.M., Brown S.J. Altered conversion of tryptophan to kynurenine in newly abstinent alcoholics. Biological Psychiatry. 23:1988;89-93.
25. Grossman C.J., Mendenhall C.L., Roselle G.A. Alcohol and immune regulation. In vivo effects of ethanol on concanavalin A sensitive thymic lymphocyte function. International Journal of Immunopharmacology. 10:1988;187-195.
26. Hu B., Hissong B.D., Carlin J.M. Interleukin-1 enhances indoleamine 2,3-dioxygenase activity by increasing specific mRNA expression in human mononuclear phagocytes. Journal of Interferon and Cytokine Research. 15:1995;617-624.
27. Jerrels T.R., Perritt D., Eckardt M.J., Marietta C. Alterations in interleukin-2 utilization by T cells from rats treated with an ethanol-containing diet. Alcoholism: Clinical and Experimental Research. 14:1990;245-249.
28. Kaplan D.R. A novel mechanism of immunosuppression mediated by ethanol. Cellular Immunology. 102:1986;1-9.
29. Khoruts A., Stahnke L., McClain C.J., Logan G., Allen J.I. Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology. 13:1991;267-276.
30. Maes M., Meltzer H.Y., Scharpe S., Bosmans E., Suy E., Minner B., De Meester I., Calabrese J., Vandervorst C., Raus J., Cosyns P. Relationships between lower plasma L-tryptophan levels and immune variables in depression. Psychiatry Research. 49:1993;11-27.
31. Maes M., Scharpé S., Meltzer H.Y., Okayli G., Bosmans E., D'Hondt P., Vanden Bossche B., Cosyns P. Increased neopterin and interferon γ secretion and lower availability of L-tryptophan in major depression: further evidence for activation of cell-mediated immunity. Psychiatry Research. 54:1994;143-160.
32. Maes M., Schotte C., Scharpé S., Martin M., Blockx P. The effects of glucocorticoids on the availability of L-tryptophan and tyrosine in the plasma of depressed patients. Journal of Affective Disorders. 18:1990;121-127.
33. Maes M., Vandevyvere J., Vandoolaeghe E., Bril T., Vandoolaeghe E., Neels H. Disorders in iron metabolism and the erythron in major depression: further evidence for an inflammatory response. Journal of Affective Disorders. 40:1996;23-33.
34. Maes M., Verkerk R., Vandoolaeghe E., Van Hunsel F., Neels H., Wauters A., Demedts P., Scharpe S. Serotonin-immune interactions in major depression: lower serum tryptophan as a marker of an immune-inflammatory response. European Archives of Psychiatry and Clinical Neuroscience. 247:1997;154-161.
35. Maes M., Wauters A., Verkerk R., Neels H., VanGastel A., Cosyns P., Scharpe S., Desnyder R. Lower L-tryptophan availability in depression: a marker of a more generalized disorder in protein metabolism. Neuropsychopharmacology. 15:1996;243-251.
36. Mantile G., Miele L., Cordella-Miele E., Singh G., Katyal L., Mukherjee A.B. Human Clara cell 10-kDa protein is the counterpart of rabbit uteroglobin. Journal of Biological Chemistry. 268:1993;20343-20351.
37. Martinez F., Abril E.R., Earnest D.L., Watson R.R. Ethanol and cytokine secretion. Alcohol. 9:1992;455-458.
38. Martinez F., Thomas N.M., Darban H., Cox T.J., Wood S., Watson R.R. Interleukin-6 and interleukin-8 production by mononuclear cells of chronic alcoholics during treatment. Alcoholism: Clinical and Experimental Research. 17:1993;1193-1197.
39. Miele L., Cordella-Miele E., Mukherjee A.B. Uteroglobin: structure, molecular biology and new perspectives on its function as a phospholipase A2 inhibitor. Endocrine Reviews. 8:1987;474-490.
40. Milson J.P., Morgan M.Y., Sherlock S. Factors affecting plasma amino acid concentrations in control subjects. Metabolism. 28:1979;313-319.
41. Moir A.T.B., Eccleston D. The effect of precursor loading in the cerebral metabolism of 5-hydroxyindoles. Journal of Neurochemistry. 15:1968;1093-1108.
42. Moldawer L.L., Georgieff M., Lundholm K. Interleukin-1, tumour necrosis factor-alpha (cachectin) and the pathogenesis of cancer cachexia. Clinical Physiology. 7:1987;263-274.
43. Morland J. Hepatic tryptophan oxygenase activity as a marker of changes in protein metabolism during chronic ethanol treatment. Acta Pharmacologica et Toxicologica. 35:1974;155-159.
44. Morland J. Effect of chronic ethanol treatment on tryptophan oxygenase, tyrosine aminotransferase and general protein metabolism in the intact and perfused rat liver. Biochemical Pharmacology. 23:1974;21-267.
45. Moroni F., Russi P., Gallo-Mezo M.A., Moneti G., Pellicciari R. Modulation of quinolinic and kynurenic acid content in the rat brain: effects of endotoxins and nicotinylalanine. Journal of Neurochemistry. 57:1991;1630-1635.
46. Murakami-Mori K., Taga T., Kishimoto T., Nakamura S. The soluble form of the IL-6 receptor (sIL-6Rα) is a potent growth factor for AIDS-associated Kaposi's sarcoma (KS) cells; the soluble form of gp130 is antagonistic for IL-6Rα-induced AIDS-KS cell growth. International Immunology. 8:1996;595-602.
47. Nelson, S., Bagby, G., Andersen, J., Nakamura, C., Shellito, J., Summer, W., 1991. The effects of ethanol, TNF and G-CSF on lung antibacterial defences. In: Friedman, H. (Ed.), Drugs of Abuse, Immunity and Immunodeficiency. Plenum, New York, pp. 24-36.
48. Nockher W.A., Scherberich J.E. Monocyte cell-surface CD14 expression and soluble CD14 antigen in hemodialysis: evidence for chronic exposure to LPS. Kidney International. 48:1995;1467-1469.
49. Pardridge W.M. Tryptophan transport through the blood-brain barrier: in vivo measurement of free and albumin-bound amino acid. Life Sciences. 25:1979;1519-1528.
50. Peri A., Cordella-Miele E., Miele L., Mukherjee A.B. Tissue specific expression of the gene coding for human Clara cell 10-kDa protein, a phospholipase A2-inhibitory protein. Journal of Clinical Investigation. 92:1993;2099-2109.
51. Pietraszek M.H., Urano T., Sumioshi K., Serizawa K., Takahashi S., Takada Y., Takada A. Alcohol-induced depression: involvement of serotonin. Alcohol and Alcoholism. 26:1991;155-159.
52. Rodriguez-Rodriguez E., Gonzales-Reimers E., Santolaria-Fernandez F., Milena-Abril A., Rodriguez-Moreno F., Oramas-Rodriguez J., Martinez-Riera A. Cytokine levels in acute alcoholic hepatitis: a sequential study. Drug and Alcohol Dependence. 39:1995;23-27.
53. Roselle G.A., Mendenhall C.L. Alteration of in vitro lymphocyte function by ethanol, acetaldehyde and acetate. Journal of Clinical and Laboratory Immunology. 9:1982;33-37.
54. Roselle G.A., Mendenhall C.L., Grossman C.J., Weesner R.E. Lymphocyte subset alterations in patients with alcoholic hepatitis. Journal of Clinical and Laboratory Immunology. 26:1988;169-173.
55. Ruiz A.D., Perez J.L.S., Martinez G.L., Calvin J.G., Extremera B.G., Gea F.G. Tumour necrosis factor, interleukin-1 and interleukin-6 in alcoholic cirrhosis. Alcohol and Alcoholism. 28:1993;319-323.
56. Saad A.J., Domiati-Saad R., Jerrels T. Ethanol ingestion increases susceptibility of mice to Listeria monocytogenes. Alcoholism: Clinical and Experimental Research. 17:1993;75-85.
57. Saito T., Taga T., Miki D., Futatsugi K., Yawata H., Kishimoto T., Yasukawa K. Preparation of monoclonal antibodies against the IL-6 signal transducer, gp130, that can inhibit IL-6-mediated function. Journal of Immunological Methods. 163:1993;217-223.
58. Scriver C.R., Gregory D.M., Sovetts D. Normal plasma free amino acid values in adults: the influence of some common physiological variables. Metabolism. 34:1985;868-873.
59. Siegal, F.L., Roach, M.K., Pomeroy, L.R., 1964. Plasma amino acid patterns in alcoholism: the effects of ethanol loading. Proceedings of the National Academy of Sciences of the United States of America 51, 605-611.
60. Sims J.E., Dower S.K. Interleukin-1 receptors. European Cytokine Network. 5:1994;539-546.
61. Spitzer, R.L., Williams, J.B.W., Gibbon, M., First, M.B., 1990. Structured Clinical Interview according to DSM-III-R. American Press, New York.
62. Szabo G., Mandrekar P., Catalano D. Inhibition of superantigen-induced T cell proliferation and monocyte IL-1β, TNF-α and IL-6 production by acute ethanol treatment. Journal of Leukocyte Biology. 58:1995;342-350.
63. Takikawa, O., Yoshida, R., Yasui, H., Hayaishi, O., 1984. The relationship between plasma kynurenine and indoleamine 2,3-dioxygenase activity in the extrahepatic tissues. In: Schlossberger, H.G., Kochen, W., Linzen, B., Steinhart, H. (Eds.), Progress in Tryptophan and Serotonin Research. Walter de Gruyter, Berlin-New York, pp. 517-520.
64. Turnell D., Cooper J. Rapid assay for amino acids in serum or urine by precolumn derivatisation and reversed-phase liquid chromatography. Clinical Chemistry. 28:1982;527-531.
65. Verma B.K., Fogarasi M., Szabo G. Down-regulation of tumor necrosis factor α activity by acute ethanol treatment in human peripheral blood monocytes. Journal of Clinical Immunology. 13:1993;8-22.
66. Wolf, H., 1974. Studies on tryptophan metabolism in man. Scandinavian Journal of Clinical and Laboratory Investigation 33 (Suppl).
67. Yuwiler A., Oldendorf W.H., Geller E.et al. The effect of albumin binding and amino acid composition on tryptophan uptake into the brain. Journal of Neurochemistry. 28:1977;1015-1023.
68. Zweig M.H., Campbell G. Receiver operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clinical Chemistry. 39:1993;561-577.