The Hsp90-specific inhibitor, geldanamycin, blocks CD28-mediated activation of human T lymphocytes

Life Sciences

Volumn 63, Issue 11, 1998, Pages 949-954

  Schnaider, Tamás ^a   Somogyi, János ^a   Csermely, Péter ^a   Szamel, Marta ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

CD28; Geldamycin; Hsp90; IL 2 receptor expression; IL 2 secretion; Molecular chaperones; T lymphocyte activation

Indexed keywords

CD28 ANTIGEN; CHAPERONE; CYTOKINE RECEPTOR; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HORMONE RECEPTOR; IMMUNOGLOBULIN G2A; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MONOCLONAL ANTIBODY BW 828; PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PROTEIN ASSEMBLY; PROTEIN FOLDING; PROTEIN TRANSPORT; RECEPTOR UPREGULATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIBODIES, BLOCKING; ANTIGENS, CD28; BENZOQUINONES; ENZYME INHIBITORS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INTERLEUKIN-2; LACTAMS, MACROCYCLIC; LYMPHOCYTE ACTIVATION; QUINONES; RECEPTORS, INTERLEUKIN-2; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0032493671     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(98)00352-X     Document Type: Article

References (24)

1. 1. F-U. HARTL, Nature 381 571-580 (1996).
2. 2. P. CSERMELY, Trends in Biochem. Sci. 22 147-149 (1997).
3. 3. U. JAKOB and J. BUCHNER, Trends Biochem. Sci. 19 205-211 (1994).
4. 4. W.B. PRATT, Annu. Rev. Pharmacol. Toxicol. 37 297-326 (1997).
5. 5 P. CSERMELY, T. SCHNAIDER, Cs. Söti, Z. PROHÁSZKA and G. NARDAI, Pharmacology and Therapeutics 79 129-168 (1998).
6. 6. D.F. NATHAN, M.H. VOS and S. LINDQUIST, Proc. Natl. Acad. Sci. USA 94 12949-12956 (1997).
7. 7. L. WHITESELL, E.G. MIMNAUGH, B. de COSTA, C.E. MYERS and L.M. NECKERS, Proc. Natl. Acad. Sci. USA 91 8324-8328 (1994).
8. 8 C.E. STEBBINS, A.A. RUSSO, C. SCHNEIDER, N. ROSEN, F.-U. HARTL and N.P. PAVLETICH, Cell 89 239-250 (1997).
9. 9. C. PRODROMOU, S.M. ROE, R. O'BRIEN, J.E. LADBURY, P.W. PIPER and L.H. PEARL, Cell 90 65-75 (1997).
10. 10 L.F. STANCATO, A.M. SILVERSTEIN, J.K. OWENS-GRILLO, Y.H CHOW, R. JOVE and W.B. PRATT, J. Biol. Chem. 272 4013-4020 (1997).
11. 11. S.D. HARTSON, D.J. BARRETT, P. BURN and R.L. MATTS, Biochemistry 35 13451-13459 (1996).
12. 12. Y. UEHARA, M. HORI, T. TAKEUCHI and H. UMEZAWA, Mol. Cell. Biol. 6 2198-2206 (1986).
13. 13. J.C. YOUNG, C. SCHNEIDER and F-U. HARTL, FEBS Lett. 418 139-143 (1997).
14. 14. T. SCHEIBEL, T. WEIKL and J. BUCHNER, Proc. Natl. Acad. Sci. USA 95 1495-1499 (1998).
15. 15. D.J. LENSHOW, T.L. WALUNAS and J.A. BLUESTONE, Annu. Rev. Immunol. 14 233-258 (1996).
16. 16. B.E. SU, M. JACINTO, T. HIBI, T. KALLUNKI, M. KARIN, and Y. BEN-NERIAH, Cell 77 727-736 (1994).
17. 17. C.A. CHAMBERS and J.P. ALLISON, Curr. Op. Immunol. 9 396-404 (1997).
18. 18. R. SIEFKEN, R. KURRLE and R. SCHWINZER, Cell. Immunol. 176 59-65 (1997).
19. 19. R. KURRLE, H.U. SCHORLEMMER, C. SHEARMAN, L. LAUFFER, K. FRANK, E.J. KANZY and F.R. SEILER, Transplant Proc. 23 272-276 (1991).
20. 20. M. SZAMEL, U. EBEL, P. UCIECHOWSKI, V. KAEVER and K. RESCH, Biochim. Biophys. Acta 1356 237-248 (1997).
21. 21. D. COUEZ, F. PAGES, M. RAGUENEAU, J. NUNES, S. KLASEN, C. MAWAS, A. TRUNEH and D. OLIVE, Mol. Immunol. 31 47-57 (1994).
22. 22. T.M. WILLIAMS, D.M. MOOLTEN, H. MAKNI, H.W. KIM, J.A. KANT and M. KAMOUN, J. Immunol. 148, 2609-2616 (1992).
23. 23. G.S. CHATTA, A.G. SPIES, S. CHANG, G.J. MIZE, P. S. LINSEY, J.A. LEDBETTER and D.R. MORRIS, J. Immunol. 153 5393-5401 (1994).
24. 24. M. TACKE, G. HANKE, T. HANKE and T. HÜNIG, Eur. J. Immunol. 27 239-247 (1997).