메뉴 건너뛰기




Volumn 38, Issue 1, 1996, Pages 75-83

Farnesyltransferase inhibitors and anti-Ras therapy

Author keywords

Cancer chemotherapy; Mitogenic signal transduction; Oncogenes

Indexed keywords

CELL PROTEIN; CYSTEINE; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE; N [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYLOXY] 3 PHENYLPROPIONYL]METHIONINE SULFONE; N [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYLOXY] 3 PHENYLPROPIONYL]METHIONINE SULFONE METHYL ESTER; ONCOPROTEIN; RAS PROTEIN;

EID: 9044237262     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01803786     Document Type: Conference Paper
Times cited : (44)

References (29)
  • 2
    • 0028137615 scopus 로고
    • Activators and effectors of ras p21 proteins
    • McCormick F: Activators and effectors of ras p21 proteins. Curr Opin Genetics Devel 4:71-76, 1994
    • (1994) Curr Opin Genetics Devel , vol.4 , pp. 71-76
    • McCormick, F.1
  • 4
    • 0026735063 scopus 로고
    • Protein isoprenylation and methylation at carboxyl-terminal cysteine residues
    • Clarke S: Protein isoprenylation and methylation at carboxyl-terminal cysteine residues. Annu Rev Biochem 61:355-386, 1992
    • (1992) Annu Rev Biochem , vol.61 , pp. 355-386
    • Clarke, S.1
  • 5
    • 0027026591 scopus 로고
    • Protein prenylation: More than just glue?
    • Cox AD, Der CJ: Protein prenylation: more than just glue? Curr Opin Cell Biol 4:1008-1016, 1992
    • (1992) Curr Opin Cell Biol , vol.4 , pp. 1008-1016
    • Cox, A.D.1    Der, C.J.2
  • 6
    • 0025877861 scopus 로고
    • Ras C-terminal processing enzymes - New drug targets?
    • Gibbs JB: Ras C-terminal processing enzymes - new drug targets? Cell 65:1-4, 1991
    • (1991) Cell , vol.65 , pp. 1-4
    • Gibbs, J.B.1
  • 8
    • 0025838675 scopus 로고
    • Regulators and effectors of ras proteins
    • Bollag G, McCormick F: Regulators and effectors of ras proteins. Annu Rev Cell Biol 7:601-632, 1991
    • (1991) Annu Rev Cell Biol , vol.7 , pp. 601-632
    • Bollag, G.1    McCormick, F.2
  • 9
    • 0027285320 scopus 로고
    • ras with GAP, exchange factors, and its biological effector target
    • ras with GAP, exchange factors, and its biological effector target. J Biol Chem 268: 9157-9160, 1993
    • (1993) J Biol Chem , vol.268 , pp. 9157-9160
    • Polakis, P.1    McCormick, F.2
  • 10
    • 0025740753 scopus 로고
    • The structure of Ras protein: A model for a universal molecular switch
    • Wittinghofer A, Pai EF: The structure of Ras protein: a model for a universal molecular switch. Trends Biochem Sci 16:382-387, 1991
    • (1991) Trends Biochem Sci , vol.16 , pp. 382-387
    • Wittinghofer, A.1    Pai, E.F.2
  • 11
    • 0027024351 scopus 로고
    • Pharmacological probes of Ras function
    • Gibbs JB: Pharmacological probes of Ras function. Semin Cancer Biol 3:383-390, 1992
    • (1992) Semin Cancer Biol , vol.3 , pp. 383-390
    • Gibbs, J.B.1
  • 12
    • 0027200883 scopus 로고
    • Direct interaction of Ras and the amino-terminal domain of Raf-1 in vitro
    • Warne PH, Rodriguez-Viciana P, Downward J: Direct interaction of Ras and the amino-terminal domain of Raf-1 in vitro. Nature 364:352-355, 1993
    • (1993) Nature , vol.364 , pp. 352-355
    • Warne, P.H.1    Rodriguez-Viciana, P.2    Downward, J.3
  • 13
    • 0026484261 scopus 로고
    • SH2 and SH3 domains: From structure to function
    • Pawson T, Gish GD: SH2 and SH3 domains: from structure to function. Cell 71:359-362, 1992
    • (1992) Cell , vol.71 , pp. 359-362
    • Pawson, T.1    Gish, G.D.2
  • 14
    • 0027267418 scopus 로고
    • High level expression of mammalian protein farnesyltransferase in a baculovirus system: The purified protein contains zinc
    • Chen W-J, Moomaw JF, Overton L, Kost TA, Casey PJ: High level expression of mammalian protein farnesyltransferase in a baculovirus system: the purified protein contains zinc. J Biol Chem 268:9675-9680, 1993
    • (1993) J Biol Chem , vol.268 , pp. 9675-9680
    • Chen, W.-J.1    Moomaw, J.F.2    Overton, L.3    Kost, T.A.4    Casey, P.J.5
  • 15
    • 0027289625 scopus 로고
    • Characterization of recombinant human farnesyl-protein transferase; cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases
    • Omer CA, Krai AM, Diehl RE, Prendergast GC, Powers S, Allen CM, Gibbs JB, Kohl NE: Characterization of recombinant human farnesyl-protein transferase; cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases. Biochemistry 32:5167-5176, 1993
    • (1993) Biochemistry , vol.32 , pp. 5167-5176
    • Omer, C.A.1    Krai, A.M.2    Diehl, R.E.3    Prendergast, G.C.4    Powers, S.5    Allen, C.M.6    Gibbs, J.B.7    Kohl, N.E.8
  • 16
    • 0025923649 scopus 로고
    • Nonidentical subunits of p21H-ras farnesyltransferase: Peptide binding and farnesyl diphosphate carrier functions
    • Reiss Y, Scabra MC, Armstrong SA, Slaughter CA, Goldstein JL, Brown MS: Nonidentical subunits of p21H-ras farnesyltransferase: peptide binding and farnesyl diphosphate carrier functions. J Biol Chem 266:10672-10677, 1991
    • (1991) J Biol Chem , vol.266 , pp. 10672-10677
    • Reiss, Y.1    Scabra, M.C.2    Armstrong, S.A.3    Slaughter, C.A.4    Goldstein, J.L.5    Brown, M.S.6
  • 19
    • 0028331587 scopus 로고
    • Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic
    • Gibbs JB, Oliff A, Kohl NE: Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell 77: 175-178, 1994
    • (1994) Cell , vol.77 , pp. 175-178
    • Gibbs, J.B.1    Oliff, A.2    Kohl, N.E.3
  • 21
    • 0027213688 scopus 로고
    • Inhibitors of Ras farnesyltransferase
    • Tamanoi F: Inhibitors of Ras farnesyltransferase. Trends Biochem Sci 18:349-353, 1993
    • (1993) Trends Biochem Sci , vol.18 , pp. 349-353
    • Tamanoi, F.1
  • 27
    • 0028318136 scopus 로고
    • Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton
    • Prendergast GC, Davide JP, deSolms SJ, Giuliani EA, Graham SL, Gibbs JB, Oliff A, Kohl NE: Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton. Mol Cell Biol 14: 4193-4202, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 4193-4202
    • Prendergast, G.C.1    Davide, J.P.2    DeSolms, S.J.3    Giuliani, E.A.4    Graham, S.L.5    Gibbs, J.B.6    Oliff, A.7    Kohl, N.E.8
  • 29
    • 0027905014 scopus 로고
    • Altered growth of human colon cancer cell lines disrupted at activated Ki-ras
    • Shirasawa S, Furuse M, Yokoyama N, Sasazuki T: Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 260:85-88, 1993
    • (1993) Science , vol.260 , pp. 85-88
    • Shirasawa, S.1    Furuse, M.2    Yokoyama, N.3    Sasazuki, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.