Biphasic modulatory action of the selective sigma receptor ligand SR 31742A on N-methyl-D-aspartate-induced neuronal responses in the frontal cortex

Brain Research

Volumn 807, Issue 1-2, 1998, Pages 208-213

  Liang, Xiaofu ^a   Wang, Rex Y ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Medial prefrontal cortex; NMDA receptors; Pyramidal cells; Sigma receptors

Indexed keywords

1 (3 CHLORO 4 CYCLOHEXYLPHENYL) 3 (HEXAHYDRO 1 AZEPINYL)PROPENE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SIGMA RECEPTOR LIGAND; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG EFFECT; DRUG RECEPTOR BINDING; FRONTAL CORTEX; LIGAND BINDING; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PSYCHOSIS; PYRAMIDAL NERVE CELL; RAT;

ANIMALS; ANTIPSYCHOTIC AGENTS; AZEPINES; EXCITATORY POSTSYNAPTIC POTENTIALS; FRONTAL LOBE; LIGANDS; MALE; N-METHYLASPARTATE; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SIGMA; VIDEOTAPE RECORDING;

EID: 0032487669     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00797-5     Document Type: Article

References (30)

1. Arvanov V.L., Wang R.Y. NMDA-induced response in pyramidal neurons of the rat medial prefrontal cortex slices consists of NMDA and non-NMDA components. Brain Research. 768:1997;361-364.
2. 2A receptor antagonist and a potential antipsychotic drug, facilitates NMDA-receptor mediated neurotransmission in the rat medial prefrontal cortical neurons in vitro. Neuropsychopharmacology. 18:1998;197-209.
3. Arvanov V.L., Liang X., Schwartz J., Grossman S., Wang R.Y. Clozapine and haloperidol modulate NMDA and non-NMDA receptor mediated neurotransmission in rat prefrontal cortical neurons in vitro. J. Pharmacol. Exp. Ther. 283:1997;226-234.
4. Bergeron R., de Montigny C., Debonnel G. Biphasic effects of sigma ligands on the neuronal response to N-methyl-D-aspartate. Naunyn-Schmiedebergs Arch Pharmacol. 351:1995;252-260.
5. 2 ligands. Synapse. 29:1998;62-71.
6. DeCoster M.A., Klette K.L., Knoght E.S., Tortella F.C. σ receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures. Brain Research. 671:1995;45-53.
7. Deutsch S.I., Weizman A., Goldman M.E., Morihisa J.M. The sigma receptor: a novel site implicated in psychosis and antipsychotic drug efficacy. Clin. Neuropharmacol. 11:1988;105-119.
8. Fletcher E.J., Church J., Abdel-Hamid K., MacDonald J.F. Blockade by sigma site ligands of N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurons. Br. J. Pharmacol. 116:1995;2791-2800.
9. 3H-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine J. Neurosci. 6:1986;1757-1770.
10. Halliwell J.V., Adams P.R. Voltage-clamp analysis of muscarinic excitation in hippocampal neurons. Brain Research. 250:1982;71-92.
11. 2+ mobilization by N-methyl-D-aspartate in primary culture of rat frontal cortical neurons. J. Pharmacol. Exp. Ther. 275:1995;207-214.
12. 2A antagonist with a favorable CNS safety profile. J. Pharmacol. Exp. Ther. 277:1996;968-981.
13. Klette K.L., DeCoster M.A., Moreton J.E., Tortella F.C. Role of calcium in sigma-mediated neuroprotection in rat primary cortical neurons. Brain Research. 704:1995;31-41.
14. Klette K.L., Lin Y., Clapp L.E., DeCoster M.A., Moreton J.E., Tortella F.C. Neuroprotective sigma ligands attenuate NMDA and trans-ACPD-induced calcium signaling in rat primary neurons. Brain Research. 756:1997;231-240.
15. Labie C., Saubusse P., Keane P.E., Le Fur G., Soubrie P. Effects of the sigma receptor ligand SR 31742A on neurotensin biosynthesis in rat basal ganglia. Synapse. 19:1995;241-246.
16. Largent B.L., Winstrom H., Snowman A.M., Snyder S.H. Novel antipsychotic drugs share high affinity for sigma receptors. Eur. J. Pharmacol. 155:1988;345-347.
17. Maj J., Rogoz Z., Skuza G., Mazela H. Neuropharmacological profile of EMD 57445, a sigma receptor ligand with potential antipsychotic activity. Eur. J Pharmacol. 315:1996;235-243.
18. 1 receptor agonist properties, facilitates NMDA receptor-dependent learning in mice. Eur. J. Pharmacol. 328:1997;9-18.
19. Maurice T., Su T.P., Parish D.W., Nabeshima T., Privat A. PRE-084, a σ selective PCP derivative, atenuates MK-801-induced impairment of learning in mice. Pharmacol. Biochem. Behav. 49:1994;859-869.
20. Okuyama S., Ogawa S., Nakazato A., Tomizawa K. Effect of NE-100, a novel sigma receptor ligand, on phencyclidine-induced delayed cognitive dysfunction in rats. Neurosci. Lett. 189:1995;60-62.
21. Poncelet M., Santucci V., Paul R., Gueudet C., Lavastre S., Guitard J., Steinberg R., Terranova J.P., Breliere J.C., Soubrie P., Le Fur G. Neuropharmacological profile of a novel and selective ligand of the sigma site: SR 31742A. Neuropharmacology. 32:1993;605-615.
22. A. Schousboe, A. Frandsen, Glutamate receptors and neurotoxicity, in: T.W. Stone (Ed.), CNS Neurotransmitters and Neuromodulators: Glutamate, CRC Press, New York, 1995, pp. 239-251.
23. 3H]haloperidol binding in guinea pig membranes Proc. Natl. Acad. Sci. USA. 81:1984;5618-5621.
24. Tanaka E., North A.R. Action of 5-hydroxytryptamine on neurons of rat cingulate cortex. J. Neurophysiol. 89:1993;1749-1757.
25. 2A receptor antagonist and a potential atypical antipsychotic drug, facilitates induction of long-term potentiation in area CA1 of the rat hippocampal slice. Brain Research. 779:1998;309-315.
26. Wang R.Y., Liang X. M100907 and clozapine, but not haloperidol or raclopride, prevent phencyclidine-induced blockade of NMDA responses in pyramidal neurons of the rat medial prefrontal cortical slice. Neuropsychopharmacology. 19:1998;74-85.
27. Whittemore E.R., Ilyin V.I., Woodward R.M. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, substrate-selectivity and mechanisms of inhibition. J. Pharmacol. Exp. Ther. 282:1997;326-338.
28. Wuarin J.P., Peacock W.J., Dubek F.E. Single-electrode voltage clamp analysis of the N-methyl-D-aspartate component of synaptic responses in neocortical slices from children with intractable epilepsy. J. Neurophysiol. 67:1992;84-93.
29. Yamamoto H., Yamamoto T., Sagi N., Klenerova V., Goji K., Kawai N., Baba A., Takmori E., Moroji T. Sigma ligands indirectly modulate the NMDA receptor-ion channel complex on intact neuronal cells via σ 1 site. J. Neurosci. 15:1996;731-736.
30. Yang C.R., Seamans J.K., Gorelova N. Electrophysiological and morphological properties of layers V-VI principal pyramidal cells in rat prefrontal cortex in vitro. J. Neurosci. 16:1996;1904-1921.