Increased HLA-DQ2-affinity of a synthetic gliadin peptide by acid- induced deamidation of glutamine residues

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 15, 1998, Pages 2039-2044

  Terreaux, Christian ^a   Walk, Tilmann ^a   Van De Wal, Yvonne ^b   Koning, Frits ^b   Jung, Günther ^a   Fleckenstein, Burkhard ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLIADIN; GLUTAMINE; HLA DQ ANTIGEN; SYNTHETIC PEPTIDE;

AMINO TERMINAL SEQUENCE; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; BINDING AFFINITY; CAPILLARY ELECTROPHORESIS; CELIAC DISEASE; DEAMINATION; HYDROLYSIS; PEPTIDE SYNTHESIS; PROTEIN SECONDARY STRUCTURE; STOMACH PH; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE ACTIVATION;

AMIDES; AMINO ACID SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, CAPILLARY; GLUTAMINE; HLA-DQ ANTIGENS; HYDROLYSIS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING;

EID: 0032483069     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00357-6     Document Type: Article

References (14)

1. 1. Marsh, M. N. Gastroenterology 1992, 102, 330.
2. 2. Sollid, L. M.; Markussen, G.; Ek, J.; Gjerde, H.; Vartdal, F.; Thorsby, E. J. Exp. Med. 1989, 169, 345.
3. 3. Sollid, L. M.; Thorsby, E. Gastroenterology 1993, 105, 136.
4. 4. Lundin, K. E. A.; Scott, H.; Hansen, T.; Paulsen, G.; Halstensen, T. S.; Fausa, O.; Thorsby, E.; Sollid, L. M. J. Exp. Med. 1993, 178, 187.
5. 5. Johansen, B. H.; Gjertsen, H. A.; Vartdal, F.; Buus, S.; Thorsby, E.; Lundin, K. E. A.; Sollid, L. M. Clin. Immunol. Immunopathol. 1996, 79, 288.
6. 6. Shidrawi, R. G.; Parnell, N. D. J.; Ciclitira, P. J.; Travers, P.; Evan, G.; Rosen-Bronson, S. Clin. Exp. Immunol. 1998, 111, 158.
7. 7. van de Wal, Y.; Kooy, Y. M. C.; Drijfhout, J. W.; Amons, R.; Koning, F. Immunogenetics 1996, 44, 246.
8. 8. Vartdal, F.; Johansen, B. H.; Friede, T.; Thorpe, C. J.; Stevanovic, S.; Eriksen, J. A.; Sletten, K.; Rammensee, H.-G.; Sollid, L. M. Eur. J. Immunol. 1996, 26, 2764.
9. 9. Jung, G.; Beck-Sickinger, A. G. Angew. Chem. Int. Ed. Engl. 1992, 31, 367.
10. 10. Tompkins, S. M.; Rota, P. A.; Moore, J. C.; Jensen, P. E. J. Immunol. Meth. 1993, 163, 209.
11. 11. Wieser, H. Acta Paediatr. 1996, Suppl. 412, 3.
12. 12. Tatham, A. S.; Marsh, M. N.; Wieser, H.; Shewry, P. R. Biochem. J. 1990, 270, 313.
13. 13. Chou, P. Y.; Fasman, G. D. Annu. Rev. Biochem. 1978, 47, 251.
14. 14. Fleckenstein, B.; Kaibacher, H.; Muller, C. P.; Stoll, D.; Halder, T.; Jung, G.; Wiesmüller, K.-H. Eur. J. Biochem. 1996, 240, 71.