Relation between gliadin structure and coeliac toxicity

Acta Paediatrica, International Journal of Paediatrics, Supplement

Volumn 85, Issue 412, 1996, Pages 3-9

  Wieser, H ^a,b  

^a DEUTSCHE FORSCHUNGSANSTALT FÜR LEBENSMITTELCHEMIE   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Amino acid sequences; coeliac disease; gliadin; peptides; toxicity; wheat

Indexed keywords

GLIADIN; PANCREAS ENZYME; SYNTHETIC PEPTIDE;

AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; CELIAC DISEASE; CONFERENCE PAPER; FOOD COMPOSITION; NONHUMAN; NUCLEOTIDE REPEAT; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; WHEAT;

EID: 0029899086     PISSN: 08035326     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (39)

1. Dicke WK. Coeliac disease. Investigation of the harmful effects of certain types of cereals on patients with coeliac disease (in Dutch). MD Thesis 1950, Utrecht
2. Kasarda DD. The relationship of wheat proteins. Cereal Foods World 1978;23:240-62
3. Wieser H, Seilmeier W, Eggert M, Belitz H-D. Tryptophangehalt von Getreideproteinen. Z Lebensm Unters Forsch 1983;177:457-60
4. Woychik JH, Boundy JA, Dimler RJ. Starch gel electrophoresis of wheat gluten proteins with concentrated urea. Arch Biochem Biophys 1961;94:477-82
5. Shewry PR, Tatham AS, Forde J, Kreis M, Miflin BJ. The classification and nomenclature of wheat gluten proteins: a reassessment. J Cereal Sci 1986;4:97-106
6. Wieser H, Seilmeier W, Belitz H-D. Klassifizierung der Proteinkomponenten des Weizenklebers. Getreide Mehl Brot 1991;45:35-8
7. Kasarda DD, Okita TW, Bernardin JE, Baecker PA, Nimmo CC, Lew EJ-L, et al. Nucleic acid (cDNA) and amino acid sequences of α-type gliadins from wheat (Triticum aestivum). Proc Natl Acad Sci USA 1984;81:4712-6
8. Rafalski JA. Structure of wheat gamma-gliadin genes. Gene 1986;43:221-9
9. Tatham AS, Shewry PR. The conformation of wheat gluten proteins. The secondary structures and thermal stabilities of α-, β-, γ- and ω-gliadins. J Cereal Sci 1985;3:103-13
10. Frazer AC, Fletcher RF, Ross CA, Shaw B, Sammons HG, Schneider R. Gluten-induced enteropathy: the effect of partially digested gluten. Lancet 1959;ii:252-5
11. Bronstein HD, Haeffner LJ, Kowlessar OD. Enzymatic digestion of gliadin: the effect of the resultant peptides in adult coeliac disease. Clin Chim Acta 1966;14:141-55
12. Van Roon JH, Haex AJCh, Seeder WA, de Jong J. Chemical and biochemical analysis of gluten toxicity. Gastroenterology 1960;94:227-35
13. Van de Kamer JH, Weijers HA. Coeliac disease V. Some experiments on the cause of the harmful effect of wheat gliadin. Acta Paediatr 1955;44:465-9
14. Wieser H, Seilmeier W, Belitz H-D. Vergleichende Untersuchungen über partielle Aminosäuresequenzen von Prolaminen und Glutelinen verschiedener Getreidearten. I. Proteinfraktionierung nach Osborne. Z Lebensm Unters Forsch 1980;170:17-26
15. Jos J, Charbonnier L. Mossé J, Olives JP, de Tand M-F, Rey J. The toxic fraction of gliadin digests in coeliac disease. Isolation by chromatography on Biogel P-10. Clin Chim Acta 1982;119:263-74
16. Wieser H, Springer G, Belitz H-D, Ashkenazi A, Idar D. Toxicity of different wheat gliadins in coeliac disease. Z Lebensm Unters Forsch 1982;175:321-6
17. Ciclitira PJ, Evans DJ, Fagg NLK, Lennox ES, Dowling RH. Clinical testing of gliadin fractions in coeliac disease. Clin Sci 1984;66:357-64
18. Howdle PD, Ciclitira PJ, Simpson FG, Losowsky MS. Are all gliadins toxic in coeliac disease? An in vitro study of α-, β-, γ- and ω-gliadins. Scand J Gastroenterol 1984;19:41-7
19. Hekkens WTJM, Haex AJC, Willighagen RGJ. Some aspects of gliadin fractionation and testing by a histochemical method. In: Booth CC, Dowling RH, editors. Coeliac disease. Proceedings of the International Coeliac Symposium. Edinburgh: Churchill Livingstone, 1970:11-9
20. Falchuk ZM, Nelson DL, Katz AJ, Bernardin JE, Kasarda DD, Hague NE, et al. Gluten-sensitive enteropathy: influence of histocompatibility type on gluten sensitivity in vitro. J Clin Invest 1980;66:227-33
21. Bernardin JE, Saunders RM, Kasarda DD. Absence of carbohydrate in celiac-toxic A-gliadin. Cereal Chem 1976;53:612-14
22. Wieser H, Belitz H-D, Ashkenazi A, Idar D. Isolation of coeliac-active peptide fractions from gliadin. Z Lebensm Unters Forsch 1983;176:85-94
23. Wieser H, Belitz H-D, Ashkenazi A. Amino acid sequence of the coeliac active peptide B3142. Z Lebensm Unters Forsch 1984;179:371-6
24. Tatham AS, Marsh MN, Wieser H, Shewry PR. Conformational studies of peptides corresponding to the coeliac-activating regions of wheat-α-gliadin. Biochem J 1990;270:313-8
25. Wieser H, Belitz H-D, Idar D, Ashkenazi A. Coeliac activity of the gliadin peptides CT-1 and CT-2. Z Lebensm Unters Forsch 1986;182:115-7
26. Jos J, de Tand MF, Arnaud-Battandier D, Boissel JP, Popineau Y, Wajcman H. Separation of pure toxic peptides from a β-gliadin subfraction using high-performance liquid chromatography. Clin Chim Acta 1983;134:189-98
27. De Ritis G, Auricchio S, Jones HW, Lew EJ-L, Bernardin JE, Kasarda DD. In vitro (organ culture) studies of the toxicity of specific A-gliadin peptides in coeliac disease. Gastroenterology 1988;94:41-9
28. KagnoffMF, Austin RF, Hubert JJ, Bernardin JE, Kasarda DD. Possible role for a human adenovirus in the pathogenesis of celiac disease. J Exp Med 1984160:1544-57
29. Karagiannis JA, Priddle JD, Jewell DP. Cell-mediated immunity to a synthetic gliadin peptide resembling a sequence from adenovirus 12. Lancet 1987;i:884-6
30. Mantzaris GJ, Karagiannis JA, Priddle JD, Jewell DP. Cellular hypersensitivity to a synthetic dodecapeptide derived from human adenovirus 12 which resembles a sequence of A-gliadin in patients with coeliac disease. Gut 1990;31:668-73
31. Mantzaris GJ, Jewell DP. In vivo toxicity of a synthetic dodecapeptide from A-gliadin in patients with coeliac disease. Scand J Gastroenterol 1991;26:392-8
32. Sturgess R, Day P, Ellis HJ, Lundin KEA, Gjertsen HA, Kontakou M, et al. Wheat peptide challenge in coeliac disease. Lancet 1994;343:758-61
33. Devery JM, Bender V, Penttila I, Skerritt JH. Identification of reactive synthetic gliadin peptides specific for coeliac disease. Int Arch Allergy Appl Immunol 1991;95:356-62
34. Skerritt JH, Devery JM, Hill AS. Chemistry, coeliac-toxicity and detection of gluten and related prolamins in food. Panminerva Med 1991;33:65-74
35. Kocna P, Mothes T, Krchnak V, Fric P. Relationship between gliadin peptide structure and their effect on the fetal chick duodenum. Z Lebensm Unters Forsch 1991;192:116-9
36. Cornell HJ, Mothes T. The activity of wheat gliadin peptides in in vitro assays for coeliac disease. Biochem Biophys Acta 1993; 1181:169-73
37. Auricchio S, de Ritis G, de Vincenzi M, Occorsio P, Silano V. Effects of gliadin-derived peptides from bread and durum wheats on small intestine cultures from rat fetus and coeliac children. Pediatr Res 1982;16:1004-10
38. Frisoni M, Vallega V, D'Egidio MG, Corazza GR, Gasbarrini G. In-vitro toxicity of gluten of three wheat species on the intestinal mucosa of coeliac patients. In: International Association for Cereal Science and Technology, ed. The role of cereals in future nutrition. Book of Abstracts, 1995, p. 8
39. Forssell F, Wieser H. Dinkel und Zöliakie. Z Lebensm Unters Forsch 1995;201:35-9