Structural role of the 30's loop in determining the ligand specificity of the human immunodeficiency virus protease

Biochemistry

Volumn 37, Issue 31, 1998, Pages 10928-10936

  Swairjo, Manal A ^a   Towler, Eric M ^a,b   Debouck, Christine ^a   Abdel Meguid, Sherin S ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; PROTEINASE INHIBITOR; TRIPEPTIDE;

ARTICLE; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; ENZYME SPECIFICITY; HUMAN IMMUNODEFICIENCY VIRUS 1; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEINASE INHIBITION; SIMIAN IMMUNODEFICIENCY VIRUS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HIV-2; HUMANS; IMIDAZOLES; ISOLEUCINE; LIGANDS; MACACA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; VALINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0032483034     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980784h     Document Type: Article

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