Synthesis of an ethyl 6-amino-3,5-difluorosalicylate derivative by sequential regioselective directed ortho- metalation; a practical synthesis of 4',5-Diamino-3',6,8-trifluoroflavone, a potent antitumor agent

Synthesis

Volumn , Issue 12, 1997, Pages 1446-1450

  Akama, Tsutomu ^a   Ueno, Kimihisa ^a   Saito, Hiromitsu ^a   Kasai, Masaji ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Directed ortho metalation; Flavone; Stille coupling

Indexed keywords

4',5 DIAMINO 3',6,8 TRIFLUOROFLAVONE; ANTINEOPLASTIC AGENT; SALICYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; NONHUMAN;

EID: 0031464699     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1997-1379     Document Type: Article

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