Site-directed mutagenesis supports a three-dimensional model of the runt domain

Journal of Molecular Biology

Volumn 277, Issue 3, 1998, Pages 509-512

  Levanon, Ditsa ^a   Eisenstein, Miriam ^a   Groner, Yoram ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

DNA binding; Fold recognition; Molecular modeling; Point mutants; Transcription factor

Indexed keywords

ARGININE; DNA; DNA DIRECTED DNA POLYMERASE BETA; GUANINE; PROTEIN; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ARTICLE; COMPUTER PROGRAM; HEMATOPOIESIS; MOLECULAR MODEL; MULTIGENE FAMILY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; SEX DETERMINATION; SITE DIRECTED MUTAGENESIS;

ARACHNIDA; DROSOPHILA; GALLUS GALLUS; HEXAPODA; MAMMALIA;

EID: 0032478542     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.1633     Document Type: Editorial

References (20)

1. Abola E., Bernstein F.C., Bryant S.H., Koetzle T.F., Weng J. Allen F.H., Bergerhoff G., Sievers R. Crystallographic Databases - Information Content, Software Systems, Scientific Applications. 1987;107-132 Data Commission of the International Union of Crystallography, Bonn/Cambridge/Chester
2. Akamatsu Y., Tsukumo S.-i., Kagoshima H., Tsurushita N., Shigesada K. A simple screening for mutant DNA binding proteins application to murine transcription factor PEBP2α subunit, a founding member of the Runt domain protein family. Gene. 185:1997;111-117
3. Crute B.E., Lewis A.F., Wu Z., Bushweller J.H., Speck N.A. Biochemical and biophysical properties of the core-binding factor α2 (AML1) DNA-binding domain. J. Biol. Chem. 271:1996;26251-26260
4. Davies J.F., Almassy R.J., Hostomsja Z., Ferre R.A., Hostomsky Z. 2.3 Å crystal structure of the catalytic domain of DNA polymerase β Cell. 76:1994;1123-1133
5. Ghozi M.C., Bernstein Y., Negreanu V., Levanon D., Groner Y. Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions. Proc. Natl Acad. Sci. USA. 93:1996;1935-1940
6. Holm L., Sander C. DNA polymerase β belongs to an ancient nucleotidyltransferase superfamily. Trends Biochem. Sci. 20:1995;345-347
7. Ito Y. Structural alterations in the transcription factor PEBP2/CBF linked to four different types of leukemia. J. Cancer. Res. Clin. Oncol. 122:1996;266-274
8. Kagoshima H., Shigesada K., Satake M., Ito Y., Miyoshi H., Ohki M., Pepling M., Gergen P. The runt domain identifies a new family of heteromeric transcription regulators. Trends Genet. 9:1993;338-341
9. Klug A. Gene regulatory proteins and their reaction with DNA. Ann. N.Y. Acad. Sci. 758:1995;143-160
10. Kurokawa M., Tanaka T., Tanaka K., Hirano N., Ogawa S., Mitani K., Yazaki Y., Hirai H. A conserved cysteine residue in the runt homology domain of AML1 is required for the DNA binding ability and the transforming activity of fibroblasts. J. Biol. Chem. 271:1996;16870-16876
11. Lenny N., Meyers S., Hiebert S.W. Functional domains of the t(8;21) fusion protein, AML-1/ETO. Oncogene. 11:1995;1761-1769
12. Levanon D., Bernstein Y., Negreanu V., Ghozi M.C., Bar-Am I., Aloya R., Goldenberg D., Lotem J., Groner Y. A large variety of alternatively spliced and differentially expressed mRNAs are encoded by the human acute myeloid leukemia gene AML1. DNA Cell Biol. 15:1996;175-185
13. Levitt M. Molecular dynamics of native protein. I Computer simulation of trajectories. J. Mol. Biol. 168:1983;595-620
14. Liu P.P., Hajra A., Wijmenga C., Collins F.S. Molecular pathogenesis of the chromosome 16 inversion in the M4Eo subtype of acute myeloid leukemia. Blood. 85:1995;2289-2302
15. Meyers S., Hiebert S.W. Indirect and direct disruption of transcriptional regulation in cancer E2F and AML-1. Crit. Rev. Eukaryot. Gene Exp. 5:1995;365-383
16. Nucifora G., Rowley J.D. AML1 and the 8;21 and 3;21 translocations in acute and chromic myeloid leukemia. Blood. 86:1995;1-14
17. Pelletier H., Sawaya M.R., Kumar A., Wilson S.H., Kraut J. Structures of ternary complexes of rat DNA polymerase β, a DNA template-primer, and ddCTP. Science. 264:1994;1891-1903
18. Rodan G.A., Haradam S.-i. The missing bone. Cell. 89:1997;677-680
19. Sippl M.J., Weitckus S., Flockner H. Merz K.H., LeGrand S. The Protein Folding Problem and Tertiary Structure Prediction. 1994;353-407 Birkhäuser, Boston, MA
20. Speck N.A., Stacy T. A new transcription factor family associated with human leukemias. Crit. Rev. Eukaryot. Gene. Exp. 5:1995;337-364