New bronchodilators selected by molecular topology

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 5, 1998, Pages 477-482

  Rios Santamarina I ^a   Garcia Domenech R ^a   Galvez J ^a   Cortijo, J ^b   Santamaria, P ^b   Morcillo, E ^b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3 (1H TETRAZOL 5YL) 9H THIOXANTHENE 9 ONE 10,10 DIOXIDE; 9 OXO 9H THIOXANTHENE 3 CARBOXYLIC 10,10 DIOXIDE ACID; ACENOCOUMAROL; BRONCHODILATING AGENT; GRISEOFULVIN; THEOPHYLLINE; UNCLASSIFIED DRUG;

ARTICLE; ASTHMA; BRONCHODILATING ACTIVITY; DISCRIMINANT ANALYSIS; MOLECULAR MODEL; MOLECULE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRONCHODILATOR AGENTS; DISCRIMINANT ANALYSIS; FEMALE; GUINEA PIGS; MALE; MUSCLE RELAXATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRACHEA;

EID: 0032478259     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00056-0     Document Type: Article

References (19)

1. 1. Loew, G. H. ; Villar, H. O. and Alkorta, Y. Pharm. Res. 1993, 10, 475.
2. 2. Briggs, J.M. ; Marrone, T.J. and McCammon, J. A. Trends Cardiovasc. Med. 1996,6, 198.
3. 3. Wess, G. Drug Discovery Today, 1996,7,529.
4. 4. Kier, L. B.;Hall, L.H. Molecular Connectivity in Structure-Activity Analysis, Research Studies Press, Letchworth, England, 1986, pp 225-246.
5. 5. García, R.;Gálvez, J.;Moliner, R.;García, F. Drug Invest. 1991,3,344 .
6. 6. De Julián-Ortiz, J.V.;García-Domenech, R.; Galvez, J.;J. Chromatogr. 1996,719,37.
7. 7. Muñoz, C.; De Julian-Ortiz, J.V.de;Gimeno, C.;Catalán, V.;Galvez, J. Rev. Esp. Quimioter. 1994,7, 279.
8. 8. Gálvez, J.;Garcia, R.;De Julian-Ortiz, J.V.;Soler, R.; J. Chem. Inf. Comput. Sci.1995,35,272.
9. 9. Gálvez, J. ;Gomez-Lechón, M.J. ;García-Domenech, R. ;Castell, J.V. Bioorg. & Med. Chem. Lett, 1996, 19, 2301.
10. 10. Antón-Fos, G.M.;García-Domenech, R.;Perez-Gimenez, F.;Peris-Ribera, J.E.;García-March, F.J.; Salabert-Salvador, M.T. Arzneim-Forsch/Drug Res. 1994,44,821.
11. 11. García-Domenech, R. ; De Gregorio-Alapont, C. ; De Julían -Ortiz, J.V. ; Gálvez, J. and Popa. L. Bioorg. & Med. Chem. Lett. 1997, 7, 567.
12. 12 Gálvez, J., Garcia, R.; De Julian-Ortiz, J.V.; Soler, R; J. Chem. Inf. Comput. Sci. 1994, 34, 1198.
13. 13. García-Domenech, R.;García-March, F.J.; Soler, R.;Galvez, J. et. al. Quant. Struct.-Act. Relat. 1996, 15, 1.
14. 14. Weinberger SE. New Engl. J. Med. 1993, 328:1389-1397.
15. 15. Kier, L.B. ; Hall, L.H. Eur. J. Med. Chem. 1977, 12, 313.
16. 16. Gálvez, J.; García, R.; Salabert M.T.;Soler R.J. Chem. Inf. Comput. Sci. 1994, 34, 520.
17. 17. Gálvez, J. ; García-Domenech, R. ; De Julian-Ortiz, J. V. and Soler, R., J. Chem. Inf. Comput. Sci. 1995, 34, 1198.
18. 18. Gálvez, J. ; García-Domenech, R. ; De Gregorio-Alapont, C. ; De Julián-Ortiz, J. V. and Popa. L. J. Mol. Graphics, 1996, 14, 272.
19. 19. Cortijo J., Sanz C.M., Villagrasa V., Morcillo E.J., Small R.C. Br.J.Pharmacol. 1994, 111, 769-776.